Comprehensive analysis of lung adenocarcinoma focus on the recurrence and response to chemotherapy
Project/Area Number |
15K10275
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory surgery
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Research Institution | Fukushima Medical University (2016-2017) National Cancer Center Japan (2015) |
Principal Investigator |
Saito Motonobu 福島県立医科大学, 医学部, 講師 (90611749)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 肺腺癌 / ドライバー遺伝子 / 遺伝子融合 / 遺伝子変異 / 肺腺がん |
Outline of Final Research Achievements |
We performed a comprehensive genetic analysis for lung adenocarcinomas (LADC) and found that the driver fusion cases showed a distinct profile with smaller numbers of nonsynonymous mutations in cancer-related genes or truncating mutations in SWI/SNF chromatin remodeling. On the other hand, pan-negative LADCs appear to develop from a large number of gene mutations, including mutations in TP53 and other cancer-related genes. Next, we have compared the frequency of each driver genes between Japan and US cohort. EGFR mutations are more prevalent in Japanese patients, whereas KRAS and BRAF mutations are more prevalent in the US. To date, the molecularly targeted drugs for KRAS mutations have not developed yet, targeted therapy have not adapted the patients with LADC in the US. In conclusion, the information of driver genes will aid in the selection of appropriate targeted therapy.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Identification of candidate responders for anti-PD-L1/PD-1 immunotherapy, Rova-T therapy, or EZH2 inhibitory therapy in small-cell lung cancer.2018
Author(s)
Saito M, Saito K, Shiraishi K, Maeda D, Suzuki H, Minamiya Y, Kono K, Kohno T, Goto A.
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Journal Title
Mol Clin Oncol.
Volume: 8
Pages: 310-314
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases.2017
Author(s)
Goto A, Tanaka M, Yoshida M, Umakoshi M, Nanjo H, Shiraishi K, Saito M, Kohno T, Kuriyama S, Konno H, Imai K, Saito H, Minamiya Y, Maeda D.
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Journal Title
PLoS One.
Volume: 12
Issue: 7
Pages: 1-6
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer.2017
Author(s)
George J, Saito M, Tsuta K, Iwakawa R, Shiraishi K, Scheel AH, Uchida S, Watanabe SI, Nishikawa R, Noguchi M, Peifer M, Jang SJ, Petersen I, Büttner R, Harris CC, Yokota J, Thomas RK, Kohno T.
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Journal Title
Clin Cancer Res
Volume: 23
Issue: 5
Pages: 1220-1226
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Multiplex Diagnosis of Oncogenic Fusion and MET Exon Skipping by Molecular Counting Using Formalin-Fixed Paraffin Embedded Lung Adenocarcinoma Tissues.2016
Author(s)
Kuniko Sunami, Koh Furuta, Koji Tsuta, Shinji Sasada, Takehiro Izumo, Takashi Nakaoku, Yoko Shimada, Motonobu Saito, Hiroshi Nokihara, Shun-ichi Watanabe, Yuichiro Ohe, Takashi Kohno
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Journal Title
Journal of Thoracic Oncology
Volume: 11(2)
Issue: 2
Pages: 203-12
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Development of lung adenocarcinomas with exclusive dependence on oncogene fusions.2015
Author(s)
Saito M, Shimada Y, Shiraishi K, Sakamoto H, Tsuta K, Totsuka H, Chiku S, Ichikawa H, Kato M, Watanabe S, Yoshida T, Yokota J, Kohno T
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Journal Title
Cancer Research
Volume: 75
Pages: 2264-71
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Book] 血液内科2017
Author(s)
齋藤元伸、河野隆志
Total Pages
130
Publisher
化学評論社
Related Report
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