| Project/Area Number |
15K10277
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
GOTO Yukinobu 筑波大学, 医学医療系, 講師
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 肺癌 / 転移 / リンパ管 / 胸管 / 肺癌の転移 / リンパ行性転移 / 血行性転移 / 胸腔内播種 / 胸管内での癌細胞の移動 / 癌細胞 / 胸腔 / 再発 / 光刺激 / ChR2 / 乳斑 / 胸膜stomata / 単球 / マクロファージ / リンパ節転移 |
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| Outline of Final Research Achievements |
Even after curative operation of lung cancer, I sometimes experienced metastasis to lymph nodes or other organs. In such a case, residual cancer cells might be stayed in the chest cavity. The cancer cells could enter the thoracic duct and flow away to other places, producing metastasis sites.
In this study I tried to see the phenomenon using fluorescent cancer cells introduced into the rat cavity and observed continuously under the fluorescent microscope. Before this experiment I succeeded to observe the cancer cells in the blood vessels and measured the velocity of the tumor blood flow. However, the attempted experiment how cancer cells move in the lymphatics was not succeeded.
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