| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We carried out functional analysis on 25 candidate genes of oncogenic driver mutation by using nest generation sequencer. Functional analysis was performed on KIT gene mutation, which is a potential candidate gene of oncogenic driver mutation, but it suggested that just only the KIT gene mutation may not have carcinogenicity. In addition, five tyrosine kinase domain mutations were analyzed for surgical cases of thymic carcinoma and lung cancer, but no mutation was observed.
We revealed that the positive cases of PD-L1 protein expression in thymic carcinoma is relatively high and immune checkpoint inhibitors can be an effective treatment for thymic carcinoma.
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