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Antitumor effect of CDK inhibitor in mesothelioma

Research Project

Project/Area Number 15K10283
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory surgery
Research InstitutionHyogo Medical University

Principal Investigator

Masaki Hashimoto  兵庫医科大学, 医学部, 助教 (40461074)

Co-Investigator(Kenkyū-buntansha) 長谷川 誠紀  兵庫医科大学, 医学部, 教授 (10252438)
近藤 展行  兵庫医科大学, 医学部, 講師 (50402889)
松本 成司  兵庫医科大学, 医学部, 講師 (60412011)
多久和 輝尚  兵庫医科大学, 医学部, 助教 (00412049)
黒田 鮎美  兵庫医科大学, 医学部, 助教 (90642570)
中道 徹  兵庫医科大学, 医学部, 病院助手 (70748384)
土井 啓至  兵庫医科大学, 医学部, 非常勤講師 (50529047)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords中皮腫 / 悪性胸膜中皮腫
Outline of Final Research Achievements

The WST-8 was used to evaluate the anti-tumor effects of CDK inhibitors(Palbociclib, Abemaciclib)in malignant pleural mesothelioma cell lines. Both agents inhibited the proliferation of cell lines in a concentration-dependent manner. The combined Abemaciclib and radiotherapy effects were assessed by measuring cell cycles, using the BrdU Flow Kit. Abemaciclib administration and radiotherapy application both resulted in more S phase reduction than in the control; the combined use of Abemaciclib and radiotherapy resulted in further S phase reduction. An animal experiment also revealed that although use of Abemaciclib alone resulted in weaker anti-tumor effects than radiotherapy alone, the combined use of Abemaciclib and radiotherapy completely suppressed subcutaneous tumor expansion.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2018 2016

All Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] CDK4/6 inhibitor with radiation therapy in malignant pleural mesothelioma2018

    • Author(s)
      Seiji Matsumoto, Toru Nakamichi, Ayumi Kuroda, Masaki Hashimoto, Teruhisa Takuwa, Nobuyuki Kondo, Seiki Hasegawa
    • Organizer
      American Society of Clinical Oncology (ASCO) Annual Meeting 2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Significance of RB Expression in Malignant Pleural Mesothelioma in Multidisciplinary Treatment Including Extrapleural Pneumonectomy2016

    • Author(s)
      Seiji Matsumoto, Toru Nakamichi, Ayumi Kuroda, Masaki Hashimoto, Teruhisa Takuwa, Nobuyuki Kondo, Seiki Hasegawa
    • Organizer
      American Society of Clinical Oncology (ASCO) Annual Meeting 2016
    • Place of Presentation
      Chicago, Illinois, USA
    • Year and Date
      2016-06-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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