Noninvasive investigation of cerebral blood flow, metabolism, and risk for stroke using MR imaging and biomarker

• Project/Area Number: 15K10289
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: Inoue Takashi 東北大学, 医学系研究科, 非常勤講師 (70326651)
• Co-Investigator(Kenkyū-buntansha): 冨永 悌二 東北大学, 医学系研究科, 教授 (00217548)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: MRI / 脳卒中 / 脳循環代謝 / 早期診断 / 非侵襲的 / 転帰予測 / バイオマーカー / 脳循環 / 脳温 / 転機予測 / 非侵襲 / バイオマーカ

Outline of Final Research Achievements

Non-invasive investigation for cerebral blood flow, metabolism, and risk factor using by MR imaging and biomarker were newly developed. Only invasive methods have been sullied for cerebral blood flow and metabolism analysis. Our newly developed methods could clarify the adverse events after cerebrovascular reconstructive surgery. We newly found the biomarker to diagnose the stroke and estimate the outcome at one month later.

Research Products

• [Journal Article] Risk factors for postoperative meningitis in patients with subarachnoid hemorrhage undergone clipping surgery (2017)
  • Author(s): Inoue Takashi, Endo Hidenori, Fujimura Miki, Ezura Masayuki, Uenohara Hiroshi, Tominaga Teiji
  • Journal Title: Cerebrovasc Dis Volume: 43 Issue: Suppl. 1 Pages: I-II
  • DOI: 10.1159/000471872
  • Peer Reviewed
• [Journal Article] Endoscopic third ventriculostomy for hydrocephalus in a patient with Klippel-Feil syndrome: a case report (2017)
  • Author(s): Ishida Tomohisa、Inoue Takashi、Fujimura Miki、Shimoda Yoshiteru、Ezura Masayuki、Uenohara Hiroshi、Tominaga Teiji
  • Journal Title: Clin Case Rep Volume: 5 Issue: 8 Pages: 1344-1347
  • DOI: 10.1002/ccr3.1063
  • Peer Reviewed / Open Access
• [Journal Article] Circumferential Wall Enhancement on Magnetic Resonance Imaging is Useful to Identify Rupture Site in Patients with Multiple Cerebral Aneurysms (2017)
  • Author(s): Omodaka Shunsuke、Endo Hidenori、Niizuma Kuniyasu、Fujimura Miki、Endo Toshiki、Sato Kenichi、Sugiyama Shin-ichiro、Inoue Takashi、Tominaga Teiji
  • Journal Title: Neurosurgery Volume: 82 Issue: 5 Pages: 638-644
  • DOI: 10.1093/neuros/nyx267
  • Peer Reviewed
• [Journal Article] Temporal and Spatial Changes in Cerebral Blood Flow during Management for Preventing Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: Serial Semiquantitative Analysis (2017)
  • Author(s): Sato Kenichi、Shimizu Hiroaki、Inoue Takashi、Fujimura Miki、Endo Hidenori、Tominaga Teiji
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 26 Issue: 9 Pages: 2027-2037
  • DOI: 10.1016/j.jstrokecerebrovasdis.2017.06.006
• [Journal Article] Nonaneurysmal Subarachnoid Hemorrhage Due to Unfused or Twiglike Middle Cerebral Artery Rupture: Two Case Reports (2016)
  • Author(s): Tashiro, R. Inoue, T. Shibahara, I. Ezura, M. Uenohara, H. Fujimura, M. Tominaga, T.
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 25 Issue: 6 Pages: 77-78
  • DOI: 10.1016/j.jstrokecerebrovasdis.2016.03.029
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical features of subarachnoid hemorrhage in patients with positive cancer history (2016)
  • Author(s): Shibahara, I. Watanabe, T. Ezura, M. Inoue, T. Fujimura, M. Kimura, N. Inoue, T. Suzuki, I. Nishino, A. Nishimura, S. Uenohara, H. Tominaga, T.
  • Journal Title: J Neurooncol Volume: 128 Issue: 1 Pages: 129-136
  • DOI: 10.1007/s11060-016-2085-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Quantitative Assessment of Circumferential Enhancement along the Wall of Cerebral Aneurysms Using MR Imaging (2016)
  • Author(s): Omodaka, S. Endo, H. Niizuma, K. Fujimura, M. Inoue, T. Sato, K. Sugiyama, S. I. Tominaga, T.
  • Journal Title: AJNR Am J Neuroradiol Volume: 37 Issue: 7 Pages: 1262-1266
  • DOI: 10.3174/ajnr.a4722
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Risk factors for meningitis after craniotomy in patients with subarachnoid hemorrhage due to anterior circulation aneurysms rupture. (2015)
  • Author(s): Inoue T, Shimizu H, Fujimura M, Sato K, Endo H, Niizuma K, Sakata H, Tominaga T.
  • Journal Title: Clinical neurology and neurosurgery Volume: 139 Pages: 302-306
  • DOI: 10.1016/j.clineuro.2015.10.029
  • Peer Reviewed
• [Journal Article] Cerebral Blood Flow after Acute Bypass with Parent Artery Trapping in Patients with Ruptured Supraclinoid Internal Carotid Artery Aneurysms (2015)
  • Author(s): Endo H, Fujimura M, Shimizu H, Inoue T, Sato K, Niizuma K, Tominaga T.
  • Journal Title: Journal of stroke and cerebrovascular diseases Volume: 24 Issue: 10 Pages: 2358-2368
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.06.028
  • Peer Reviewed
• [Journal Article] Quantitative analysis of early postoperative cerebral blood flow contributes to the prediction and diagnosis of cerebral hyperperfusion syndrome after revascularization surgery for moyamoya disease (2015)
  • Author(s): FUJIMURA M, Niizuma K, Endo H, Sato K, Inoue T, Shimizu H, Tominaga T
  • Journal Title: Neurol Res Volume: 37 Issue: 2 Pages: 131-138
  • DOI: 10.1179/1743132814y.0000000432
  • Peer Reviewed
• [Journal Article] Cerebral blood flow measurement using single photon emission computed tomography with venous blood sampling. (2015)
  • Author(s): Inoue T, Fujiwara S, Ezura M, Uenohara H, Fujimura M, Tominaga T.
  • Journal Title: Cerebrovasc Dis. Volume: 37 Issue: Suppl. 2 Pages: 18-18
  • DOI: 10.1159/000431011
  • Peer Reviewed
• [Presentation] 破裂脳動脈瘤開頭クリッピング術後髄膜炎の危険因子および転帰 (2017)
  • Author(s): 井上敬
  • Organizer: 第46回日本脳卒中の外科学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪）
  • Year and Date: 2017-03-16
• [Presentation] CEA周術期脳血流評価 (2017)
  • Author(s): 井上敬
  • Organizer: 第40回日本脳神経CI学会総会
  • Place of Presentation: 鹿児島サンロイヤルホテル（鹿児島）
  • Year and Date: 2017-03-03
• [Presentation] Fractional anisotropy values of pyramidal tract and motor functional recovery: intracerebral hemorrhage patients study (2017)
  • Author(s): Takashi Inoue, Yasutaka Kuzu, Yoshiyuki Kanbara, Shunro Fujiwara, Kuniaki Ogasawara, Teiji Tominaga
  • Organizer: 25th International Society of Magnetic Resonance in Medicine
  • Int'l Joint Research
• [Presentation] Risk factors for postoperative meningitis in patients with subarachnoid hemorrhage undergone clipping surgery (2017)
  • Author(s): Takashi Inoue, Hidenori Endo, Miki Fujimura, Masayuki Ezura, Hiroshi Uenohara, Teiji Tominaga
  • Organizer: 26th European Stroke Conference
  • Int'l Joint Research
• [Presentation] 未破裂脳動脈瘤治療方針および観察間隔－2015脳卒中ガイドラインその後 (2017)
  • Author(s): 井上敬、藤村幹、遠藤英徳、江面正幸、上之原広司、藤原悟、冨永悌二
  • Organizer: 第76回日本脳神経外科学会総会
• [Presentation] 未破裂脳動脈瘤至適MRA間隔 (2017)
  • Author(s): 井上敬、藤村幹、遠藤英徳、江面正幸、上之原広司、藤原悟、冨永悌二
  • Organizer: 第45回日本磁気共鳴医学会
• [Presentation] 静脈血から動脈血放射性カウントを推定することによるSPECT定量的脳血流量測定 (2017)
  • Author(s): 井上敬、藤村幹、江面正幸、上之原広司、冨永悌二
  • Organizer: 第60回日本脳循環代謝学会
• [Presentation] CEA術前脳循環予備能測定は必要か？ (2016)
  • Author(s): 井上敬
  • Organizer: 第59回日本脳循環代謝学会学術集会
  • Place of Presentation: あわぎんホール（徳島）
  • Year and Date: 2016-11-11
• [Presentation] Outcome and risk factors for meningitis after craniotomy in patients with subarachnoid hemorrhage (2016)
  • Author(s): Takashi Inoue
  • Organizer: 10th World Stroke Congress
  • Place of Presentation: Hyderabad (India)
  • Year and Date: 2016-10-26
  • Int'l Joint Research
• [Presentation] 妊婦脳動静脈奇形の治療 (2016)
  • Author(s): 井上敬
  • Organizer: 第75回日本脳神経外科学会総会
  • Place of Presentation: 福岡国際会議場（福岡）
  • Year and Date: 2016-09-29
• [Presentation] "Meningitis after clipping surgery in patients with subarachnoid hemorrhage " (2016)
  • Author(s): Takashi inoue
  • Organizer: 13th JKJC (Japan-Korea Joint conference on surgery for cerebral stroke
  • Place of Presentation: Busan (Korea)
  • Year and Date: 2016-09-22
  • Int'l Joint Research
• [Presentation] 無症候性頚部頚動脈狭窄症に対する治療方針：ACST2参加施設からの報告 (2016)
  • Author(s): 井上敬
  • Organizer: 日本脳卒中学会
  • Place of Presentation: ロイトン札幌（札幌）
  • Year and Date: 2016-04-14
• [Presentation] データに基づく未破裂脳動脈瘤治療方針および観察間隔 (2015)
  • Author(s): 井上敬、藤村幹、遠藤英徳、江面正幸、上之原広司、冨永悌二
  • Organizer: 第74回日本脳神経外科学会総会
  • Place of Presentation: ロイトン札幌（札幌）
  • Year and Date: 2015-10-14
• [Presentation] Basic technique for carotid endarterectomy. (2015)
  • Author(s): Inoue T, Fujimura M, Tominaga T
  • Organizer: International Society of Minimaly invasive surgery
  • Place of Presentation: Kuala Lumpur (Malaysia)
  • Year and Date: 2015-10-02
  • Int'l Joint Research / Invited
• [Presentation] Quantitative measurement of cerebral blood flow using single photon emission computed tomography with venous blood sampling (2015)
  • Author(s): Inoue T, Shimizu H, Fujimura M, Sato K, Endo H, Niizuma K, Sakata H, Tominaga T
  • Organizer: Brain 2015
  • Place of Presentation: Vancouver (Canada)
  • Year and Date: 2015-06-27
  • Int'l Joint Research
• [Presentation] Prediction of the onset day using by T2*-weighted magnetic resonance imaging in patients with subarachnoid hemorrhage (2015)
  • Author(s): Inoue T, Takada S, Shimizu H, Niizuma K, Tominaga T
  • Organizer: 23rd International Society of Magnetic Resonance in Medicine
  • Place of Presentation: Tronto (Canada)
  • Year and Date: 2015-05-30
  • Int'l Joint Research
• [Presentation] Cerebral blood flow measurement using single photon emission computed tomography with venous blood sampling (2015)
  • Author(s): Inoue T, Fujiwara S, Ezura M, Uenohara H, Fujimura M, Tominaga T
  • Organizer: European Stroke Conference
  • Place of Presentation: Vienna (Austria)
  • Year and Date: 2015-05-13
  • Int'l Joint Research
• [Book] スズケンメディカル (2017)
  • Author(s): 井上敬
  • Total Pages: 3
  • Publisher: ライフメディコム
• [Book] スズケンファーマ (2017)
  • Author(s): 井上敬
  • Total Pages: 1
  • Publisher: ライフメディコム
• [Book] スズケンメディカル (2017)
  • Author(s): 井上敬
  • Total Pages: 2
  • Publisher: スズケン
• [Book] スズケンファーマ (2017)
  • Author(s): 井上敬
  • Total Pages: 1
  • Publisher: スズケン