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Subcallosal and Heubner artery infarcts following surgical repair of an anterior communicating artery aneurysm

Research Project

Project/Area Number 15K10290
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionTohoku University

Principal Investigator

TAKAHASHI Shouki  東北大学, 医学系研究科, 名誉教授 (80148874)

Co-Investigator(Kenkyū-buntansha) 藤村 幹  東北大学, 医学系研究科, 非常勤講師 (00361098)
麦倉 俊司  東北大学, 大学病院, 准教授 (20375017)
森 悦朗  東北大学, 医学系研究科, 名誉教授 (30368477)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsくも膜下出血 / 脳動脈瘤 / 認知機能障害 / 記憶 / MRI / 健忘症 / 動脈瘤 / 記憶障害 / 高次脳機能障害 / 前交通動脈瘤
Outline of Final Research Achievements

Postoperative infarctions following surgical repair of anterior communicating artery (ACoA) aneurysms are classified as involvement of the subcallosal artery (the largest unpaired perforator of the ACoA), the recurrent artery of Heubner (RAH), or a combination of both. Postoperative amnesia is most likely caused by an infarction in the territory of the subcallosal artery, particularly in the column of the fornix, a constituent of the Papez neuronal circuit. Infarction in the RAH territory alone is unlikely to cause significant amnesia. Infarcted foci in the RAH territory, when associated with a subcallosal artery infarction, can cause considerable frontal dysfunction due to impaired frontostriatal circuits in patients with postoperative amnesia, with resultant worsening of the long-term outcome or quality of life.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (30 results)

All 2018 2017 2016 2015

All Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 20 results,  Open Access: 7 results) Presentation (10 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Relationship between Ischemic Injury and Patient Outcomes after Surgical or Endovascular Treatment of Ruptured Anterior Communicating Artery Aneurysms.2018

    • Author(s)
      Mugikura S, Takahashi S, Takase K
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: - Issue: 4 Pages: E51-E52

    • DOI

      10.3174/ajnr.a5564

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Traumatic midline subarachnoid hemorrhage on initial computed tomography as a marker of severe diffuse axonal injury.2018

    • Author(s)
      Mata-Mbemba D, Mugikura S, Nakagawa A, Murata T, Ishii K, Kushimoto S, Tominaga T, Takahashi S, Takase K
    • Journal Title

      J Neurosurg

      Volume: - Issue: 5 Pages: 1317-1324

    • DOI

      10.3171/2017.6.jns17466

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Letter by Mugikura and Takahashi Regarding Article, "Ischemic Amnesia: Causes and Outcome".2018

    • Author(s)
      Mugikura S, Takahashi S
    • Journal Title

      Stroke

      Volume: - Issue: 1

    • DOI

      10.1161/strokeaha.117.019366

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Subcallosal and Heubner artery infarcts following surgical repair of an anterior communicating artery aneurysm: a causal relationship with postoperative amnesia and long-term outcome.2018

    • Author(s)
      Mugikura S, Kikuchi H, Fujimura M, Mori E, Takahashi S, Takase K
    • Journal Title

      Jpn J Radiol

      Volume: - Issue: 2 Pages: 81-89

    • DOI

      10.1007/s11604-017-0703-2

    • NAID

      210000178728

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ischemic White Matter Lesions Associated With Medullary Arteries: Classification of MRI Findings Based on the Anatomic Arterial Distributions.2017

    • Author(s)
      Akashi T, Takahashi S, Mugikura S, Sato S, Murata T, Umetsu A, Takase K
    • Journal Title

      AJR Am J Roentgenol

      Volume: - Issue: 3 Pages: W160-W168

    • DOI

      10.2214/ajr.16.17231

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Sequel of Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan2017

    • Author(s)
      Mugikura S, Fujimura M, Takahashi S, Takase K
    • Journal Title

      Radiology

      Volume: 284 Issue: 1 Pages: 301-303

    • DOI

      10.1148/radiol.2017170252

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative analysis of contrast-enhanced ultrasound imaging in invasive breast cancer: a novel technique to obtain histopathological information of microvessel density2017

    • Author(s)
      Mori N, Mugikura S, Takahashi S, Ito K, Takasawa C, Li L, Miyashita M, ko Kasajima A, Mori Y, Ishida T, Kodama T, Takase K
    • Journal Title

      Ultrasound Med Biol

      Volume: 43(3) Issue: 3 Pages: 607-614

    • DOI

      10.1016/j.ultrasmedbio.2016.11.009

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] T2 relaxometry improves detection of non-sclerotic epileptogenic hippocampus.2016

    • Author(s)
      Sato S, Iwasaki M, Suzuki H, Mugikura S, Jin K, Tominaga T, Takase K, Takahashi S, Nakasato N.
    • Journal Title

      Epilepsy Res.

      Volume: 126 Pages: 1-9

    • DOI

      10.1016/j.eplepsyres.2016.06.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gender differences in ventromedial prefrontal cortex activity associated with valuation of faces.2016

    • Author(s)
      Ito A, Fujii T, Abe N, Kawasaki I, Hayashi A, Ueno A, Yoshida K, Sakai S, Mugikura S, Takahashi S, Mori E.
    • Journal Title

      Neuroscience.

      Volume: 328 Pages: 194-200

    • DOI

      10.1016/j.neuroscience.2016.04.047

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Implications of Off-Label Use of Acetazolamide in the Management of Moyamoya Disease in Japan.2016

    • Author(s)
      Mugikura S, Fujimura M, Takahashi S.
    • Journal Title

      Radiology

      Volume: 279(2) Issue: 2 Pages: 652-3

    • DOI

      10.1148/radiol.2016152305

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Canadian CT head rule and New Orleans Criteria in mild traumatic brain injury: comparison at a tertiary referral hospital in Japan.2016

    • Author(s)
      Mata-Mbemba D, Mugikura S, Nakagawa A, Murata T, Kato Y, Tatewaki Y, Takase K, Kushimoto S, Tominaga T, Takahashi S.
    • Journal Title

      Springerplus

      Volume: 25 Issue: 1 Pages: 176-176

    • DOI

      10.1186/s40064-016-1781-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered white matter metabolism in delayed neurologic sequelae after carbon monoxide poisoning: A proton magnetic resonance spectroscopic study.2016

    • Author(s)
      Kuroda H, Fujihara K, Mugikura S, Takahashi S, Kushimoto S, Aoki M.
    • Journal Title

      J Neurol Sci.

      Volume: 15 Pages: 161-169

    • DOI

      10.1016/j.jns.2015.12.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Medial temporal lobe activity associated with the successful retrieval of destination memory.2016

    • Author(s)
      Mugikura S, Abe N, Ito A, Kawasaki I, Ueno A, Takahashi S, Fujii T.
    • Journal Title

      Exp Brain Res.

      Volume: 234(1) Issue: 1 Pages: 95-104

    • DOI

      10.1007/s00221-015-4415-5

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential activation of the ventromedial prefrontal cortex between male and female givers of social reputation.2016

    • Author(s)
      Kawasaki I, Ito A, Fujii T, Ueno A, Yoshida K, Sakai S, Mugikura S, Takahashi S, Mori E.
    • Journal Title

      Neurosci Res.

      Volume: 103 Pages: 27-33

    • DOI

      10.1016/j.neures.2015.07.010

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peritumoral apparent diffusion coefficients for prediction of lymphovascular invasion in clinically node-negative invasive breast cancer.2016

    • Author(s)
      Mori N, Mugikura S, Takasawa C, Miyashita M, Shimauchi A, Ota H, Ishida T, Kasajima A, Takase K, Kodama T, Takahashi S.
    • Journal Title

      Eur Radiol.

      Volume: 26(2) Issue: 2 Pages: 340-341

    • DOI

      10.1007/s00330-015-3847-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Utility of diffusion tensor imaging parameters for diagnosis of hemimegalencephaly.2015

    • Author(s)
      Oikawa T, Tatewaki Y, Murata T, Kato Y, Mugikura S, Takase K, Takahashi S.
    • Journal Title

      Neuroradiol J.

      Volume: 28(6) Issue: 6 Pages: 628-633

    • DOI

      10.1177/1971400915609334

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A comparative study of the extent of cerebral microvascular injury following whole-brain irradiation versus reduced-field irradiation in long-term survivors of intracranial germ cell tumors.2015

    • Author(s)
      Li L, Mugikura S, Kumabe T, Murata T, Mori E, Takase K, Jingu K, Takahashi S.
    • Journal Title

      Radiother Oncol.

      Volume: 117(2) Issue: 2 Pages: 302-307

    • DOI

      10.1016/j.radonc.2015.09.017

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fornix Infarction due to Involvement of Posterior Circulation.2015

    • Author(s)
      Mugikura S, Takahashi S.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 24(12) Issue: 12 Pages: 2883-2885

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.07.009

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cortical Microvascularization and Leptomeningeal Collaterals in Moyamoya Disease.2015

    • Author(s)
      Mugikura S, Fujimura M, Takahashi S.
    • Journal Title

      Eur Neurol.

      Volume: 73 Issue: 5-6 Pages: 351-352

    • DOI

      10.1159/000430811

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Infarction in the pars libera of the column of fornix including pre (cholinergic)- and post (circuit of Papez fiber tracts)-commissural fibers causes "basal forebrain" amnesia.2015

    • Author(s)
      Mugikura S, Takahashi S.
    • Journal Title

      Neuroradiology

      Volume: Jul;57(7) Issue: 7 Pages: 757-9

    • DOI

      10.1007/s00234-015-1504-x

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 髄質動脈に関連する虚血性大脳白質病変:動脈解剖に基づいたMRI所見の分類2018

    • Author(s)
      明石 敏昭、高橋 昭喜、麦倉 俊司、佐藤 志帆、森下 陽平、村田 隆紀、梅津 篤司、高瀬 圭
    • Organizer
      日本神経放射線学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Fast Dynamic Contrast-enhanced MRI: a novel technique to obtain histopathological information of microvessel density in invasive breast cancer2018

    • Author(s)
      N. Mori, F. Pineda, S. Mugikura, H. Tamura, S. Takahashi, G. Karczmar, H. Abe, K. Takase
    • Organizer
      European Congress of Radiology2018
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Infarction in the Subcallosal Artery and Recurrent Artery of Heubner Following Surgical Repair of the Anterior Communicating Artery Aneurysm: A Causal Relationship with Postoperative Amnesia and Neuropsychological Findings2017

    • Author(s)
      森 菜緒子、阿部 裕之、麦倉 俊司、高橋 昭喜、 Federico Pineda、Gregory S. Karczmar、高瀬 圭
    • Organizer
      北米放射線学会
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 乳癌における拡散強調画像ADC値と病理学的なパラメータの対比2017

    • Author(s)
      小池 大吾、森 菜緒子、張昌模、田村 元、麦倉俊司、高橋昭喜、高瀬 圭、井上 千裕
    • Organizer
      第137回日本医学放射線学会北日本地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 頭蓋内Growing teratonma syndromeの1例2017

    • Author(s)
      村田隆紀、梅津篤司、麦倉俊司、北見昌広、明石敏昭、菅野麻里那、佐藤志帆、田村元、高橋昭喜、高瀬圭
    • Organizer
      第136回日本医学放射線学会北日本地方会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Morphologic features of intratumoral susceptibility signals on PRESTO for predicting the WHO grade of gliomas2016

    • Author(s)
      Li Li, Mugikura Shunji, Murata Takaki, Akashi Toshiaki, Sato Shiho, Kanamori Masayuki, Watanabe Mika, Tamura Hajime, Takahashi Shoki, Takase kei
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ(埼玉県大宮市)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 伝達先記憶の神経基盤:functional MRIによる内側側頭葉関与の証明2016

    • Author(s)
      麦倉俊司、阿部修士、伊藤文人、川崎伊織、上野彩、高橋昭喜、高瀬圭、藤井俊勝
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] PRESTO-MRIによる神経膠腫内血管形態パターンとWHO gradeの関係2016

    • Author(s)
      李麗、麦倉俊司、村田隆紀、明石敏昭、佐藤志帆、Mata-Mbemba D、金森 政之、渡辺 みか、高橋昭喜、高瀬 圭.
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 頭蓋内胚細胞性腫瘍長期生存例におけるT2*強調像による微小血管障害評価:全脳vs拡大局所照射2016

    • Author(s)
      李麗、麦倉俊司、隈部俊宏、村田隆紀、森悦朗、高瀬 圭、高橋昭喜、神宮啓一.
    • Organizer
      第75回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 前交通動脈穿通枝の3D-CISSによる評価2016

    • Author(s)
      麦倉俊司、藤村幹、高橋昭喜、高瀬圭
    • Organizer
      第39回東北脳血管障害研究会
    • Place of Presentation
      艮陵会館(宮城県仙台市)
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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