Combined therapy for brain infarction with slow releasing drug delivery system and immature cells.
| Project/Area Number |
15K10291
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | University of Tsukuba |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | 脳梗塞 / 幹細胞治療 / Drug delivery system / 脂肪細胞由来幹細胞 / 脳梗塞治療 / 再生医療 / 脂肪由来幹細胞 / DDS / 生体内細胞分化コントロール / 脱分化脂肪細胞 / 幹細胞 |
|---|
| Outline of Final Research Achievements |
1)Brain infarction rats were treated using adipose-cell derived stem cells (ACSC), which were injected intra-arterially. Results: The mortality of ACSC-treated rats was lower than that of control rats. In survived brain infarction rats, infarction area of ASCS-treated rats was significantly decreased than that of control rats. Neurological examination was also improved in ASCS-treated rats. Hitological examination showed the existence of ACSC in brain infarction area.
2)Drug delivery system slowly releasing cytokines to central nervous system was developed. Cytokines were loaded on burr hole button that was used in cranioplasty as bone filling biomaterials. In-vivo slow releasing of cytokines was recognized from this burr hole button.
|
Report
(4 results)
Research Products
(8 results)
-
[Journal Article] Neurovascular unit protection from cerebral ischemia-reperfusion injury by radical-containing nanoparticle in mice.2017
Author(s)
Hosoo H, Marushima A, Nagasaki Y, Hirayama A, Ito H, Puentes S, Mujagic A, Tsurushima H, Tsuruta W, Suzuki K, Matsui H, Matsumaru Y, Yamamoto T, Matsumura A.
-
Journal Title
Stroke
Volume: 48(8)
Pages: 2238-2247
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Hybrid Assistive Limb enhances the gait fuctions in sub-acute stroke stage: A multi single-case study.2016
Author(s)
Yoshikawa K, Mizukami M, Kawamoto H, Sano A, Koseki K, Hashizume Y, Asakawa Y, Iwamoto K, Kohno Y, Nagata H, Nakai K, Tsurushima H
-
Journal Title
Physiotherapy Practice Research
Volume: 37
Pages: 91-100
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Gait training of subacute stroke patients using a hybrid assiative limb: a pilot study.2016
Author(s)
Mizukami M, Yoshikawa K, Kawamoto H, Sano A, Koseki K, Asakwa Y, Iwamoto K, Nagata H, Tsurushima H, Nakai K, Marushima A, Sankai Y, Matsumura A
-
Journal Title
Disabil. Rehabil. Assist Technol.
Volume: Mar. 26
Pages: 1-8
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
