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Lifetime effects of unruptured intracranial aneurysms

Research Project

Project/Area Number 15K10292
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionGunma University

Principal Investigator

Yoshimoto Yuhei  群馬大学, 大学院医学系研究科, 教授 (50242061)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords未破裂脳動脈瘤 / マルコフモデル
Outline of Final Research Achievements

A mathematical model of the natural history of intracranial aneurysms was constructed, in which the hypothetical individuals with or without unruptured aneurysm transit between discrete health states. The annual rupture rate of small aneurysms was assumed to be 0.5%. The analyses were continued until cumulative death rate from subarachnoid hemorrhage or other causes reached 1.0.
Age-specific ratios of death of subarachnoid hemorrhage in the individuals harboring unruptured aneurysm, if dying at 60 years old, were 25% in males and 43% in females. These ratios decreased rapidly with higher age. The majority (more than 90%) of patients with small aneurysms were expected to die of diseases other than subarachnoid hemorrhage. In the baseline analysis, lifetime lost to small aneurysms could be estimated as 3.8% for males and 4.2% for females, but somewhat larger impact could be identified in the young and/or female individuals than in the elderly and/or male individuals.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(1 results)

All 2016

All Journal Article

  • [Journal Article] Lifetime effects of small unruptured intracranial aneurysms.2016

    • Author(s)
      Aishima K, Shimizu T, Aihara M, Yoshimoto Y
    • Journal Title

      World Neurosurgery

      Volume: 95 Pages: 434-440

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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