| Project/Area Number |
15K10294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TANAKA Yoji 東京医科歯科大学, 医学部附属病院, 講師 (80323682)
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| Co-Investigator(Kenkyū-buntansha) |
成相 直 東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (00228090)
宮坂 尚幸 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70313252)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脳血流 / 正常妊娠 / もやもや病合併妊娠 / MRI / arterial spin labeling / 脳血管障害合併妊娠 / もやもや病 / 脳血管障害合併妊婦 / Arterial spin labeling法 / モヤモヤ病 |
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| Outline of Final Research Achievements |
[PURPOSE] To evaluate the maternal cerebral blood flow (CBF) change measured by arterial spin labeling (ASL) MRI in healthy subjects and in the patients with cerebrovascular disease (CVD). [SUBJECTS AND METHODS] ASL was performed to the healthy non-pregnant women (Group A, n=10), healthy pregnant women (Group B, n=8), and pregnant women with CVD, including 28 cases of moyamoya disease (MMD). 16 of MMD patients also had ASL-MRI at non-pregnant period. [RESULTS] In healthy groups, global CBF showed no significant change during pregnant period. Regional distribution of CBF was also similar between group A and B. Contrarily, the global CBF significantly dropped during pregnancy in the MMD patients. Among the MMD patients, 7 had multiple scans in different trimester of pregnancy and suggested that CBF dropped in the 3rd trimester. [CONCLUSIONS] The result indicated that cerebral hemodynamic may change differently between healthy women and the patients with MMD.
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