Role of periodontal disease in the rupture of intracranial aneurysms

• Project/Area Number: 15K10305
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: The University of Tokushima
• Principal Investigator: SATOMI Junichiro 徳島大学, 大学院医歯薬学研究部(医学系), 准教授 (10304510)
• Co-Investigator(Kenkyū-buntansha): 永田 俊彦 徳島大学, 大学院医歯薬学研究部(歯学系), 名誉教授 (10127847) ; 多田 恵曜 徳島大学, 病院, 特任講師 (30547964)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 脳・神経 / くも膜下出血 / 歯周病 / 歯周菌 / 炎症反応 / エストロゲン / 高塩分摂取 / 高血圧

Outline of Final Research Achievements

Subarachnoid hemorrhage due to the rupture of cerebral aneurysms is catastrophic and poor prognosis. A recent study reported the presence of periodontal bacteria DNA in the rupture aneurysms. In our aneurysm models, the peritoneal injection of Pg-LPS increased the incidence of rupture aneurysms. We studied the relationships between the severity of periodontal disease and cerebral aneurysms. The patients with unruptured or ruptured aneurysms were compared with healthy control subjects. The incidence of ruptured aneurysms was markedly increased in the patients with severe periodontal diseases whose periodontal pockets were deeper and periodontal bacteria content were larger than the others. The plasma levels of MMP-9 and procollagen I were significantly higher in the patients with ruptured aneurysm. Our findings suggest the relationship between cerebral aneurysm rupture and severe periodontal disease including edentulous caused by chronic periodontal inflammation.

Research Products

• [Journal Article] Intra-arterial high signals on arterial spin labeling perfusion images predict the occluded internal carotid artery segment (2017)
  • Author(s): Sogabe S, Satomi J, Tada Y, Kanematsu Y, Kuwayama K, Yagi K, Yoshioka S, Mizobuchi Y, Mure H, Yamaguchi I, Abe T, Yamamoto N, Kitazato KT, Kaji R, Harada M, Nagahiro S
  • Journal Title: Neuroradiology. Volume: － Issue: 6 Pages: 587-595
  • DOI: 10.1007/s00234-017-1828-9
  • Peer Reviewed / Open Access
• [Journal Article] Treatment Outcome of Carotid Artery Stenting Underwent within 14 Days of Stroke Onset – Consideration of Safety and Efficacy of Urgent Carotid Artery Stenting for Neurologically Progressing Patients (2017)
  • Author(s): Kanematsu Y, Satomi J, Kuwayama K, Yamaguchi I, Yoshioka S, Kinouchi T, Tada Y, Yamamoto N, Matsubara S, Satoh K, Nagahiro S
  • Journal Title: Neurologia medico-chirurgica Volume: 57 Issue: 6 Pages: 278-283
  • DOI: 10.2176/nmc.oa.2016-0236
  • NAID: 130006882460
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] Hyperhomocysteinemia induced by excessive methionine intake promotes rupture of cerebral aneurysms in ovariectomized rats, J Neuroinflammation (2016)
  • Author(s): Korai M, Kitazato KT, Tada Y, Miyamoto T, Shimada K, Matsushita N, Kanematsu Y, Satomi J, Hashimoto T, Nagahiro S
  • Journal Title: J Neuroinflammation Volume: 13 Issue: 1 Pages: 165-175
  • DOI: 10.1186/s12974-016-0634-3
  • Peer Reviewed / Open Access
• [Journal Article] Site-specific elevation of interleukin-1β and matrix metalloproteinase-9 in the Willis circle by hemodynamic changes is associated with rupture in a novel rat cerebral aneurysm model (2016)
  • Author(s): Miyamoto T, Kung DK, Kitazato KT, Yagi K, Shimada K, Tada Y, Korai M, Kurashiki Y, Kinouchi T, Kanematsu Y, Satomi J, Hashimoto T, Nagahiro S
  • Journal Title: J Cereb Blood Flow Metab Volume: － Issue: 8 Pages: 2795-2805
  • DOI: 10.1177/0271678x16675369
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The accumulation of brain water-free sodium is associated with ischemic damage independent of the blood pressure in female rats (2015)
  • Author(s): Sumiyoshi M, Kitazato KT, Yagi K, Miyamoto T, Kurashiki Y, Matsushita N, Kinouchi T, Kuwayama K, Satomi J, Nagahiro S
  • Journal Title: Brain Res Volume: 1616 Pages: 37-44
  • DOI: 10.1016/j.brainres.2015.04.051
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] PPARγ-Dependent and -Independent Inhibition of the HMGB1/TLR9 Pathway by Eicosapentaenoic Acid Attenuates Ischemic Brain Damage in Ovariectomized Rats (2015)
  • Author(s): Sumiyoshi M, Satomi J, Kitazato KT, Yagi K, Shimada K, Kurashiki Y, Korai M, Miyamoto T, Suzue R, Kuwayama K, Nagahiro S
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 24 Issue: 6 Pages: 1187-1195
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.01.009
  • Peer Reviewed / Open Access
• [Journal Article] Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan (2015)
  • Author(s): Tada Y, Yagi K, Uno M, Matsushita N, Kanematsu Y, Kuwayama K, Shimada K, Nishi K, Hirasawa M, Satomi J, Kitazato KT, Kageji T, Matsuura E, Nagahiro S
  • Journal Title: J Stroke Cerebrovasc Dis Volume: 24 Issue: 7 Pages: 1487-1492
  • DOI: 10.1016/j.jstrokecerebrovasdis.2015.03.015
  • Peer Reviewed / Open Access
• [Journal Article] Two-layered susceptibility vessel sign on 3-tesla T2*-weighted imaging is a predictive biomarker of stroke subtype (2015)
  • Author(s): Yamamoto N, Satomi J, Tada Y, Harada M, Izumi Y, Nagahiro S, Kaji R
  • Journal Title: Stroke Volume: 46 Issue: 1 Pages: 269-271
  • DOI: 10.1161/strokeaha.114.007227
  • Peer Reviewed / Open Access
• [Journal Article] Prevention of Retrograde Blood Flow Into Large or Giant Internal Carotid Artery Aneurysms by Endovascular Coil Embolization with High-Flow Bypass: Surgical Technique and Long-Term Results (2015)
  • Author(s): Nakajima N, Nagahiro S, Satomi J, Tada Y, Nakajima K, Sogabe S, Hanaoka M, Matsubara S, Uno M, Satoh K
  • Journal Title: World Neurosurg Volume: 83 Issue: 6 Pages: 1127-1134
  • DOI: 10.1016/j.wneu.2015.01.037
  • Peer Reviewed / Open Access
• [Presentation] Acute stroke management using image sharing on smart phones and tablet devices (2017)
  • Author(s): Satomi J, Kanematsu Y, Korai M, Yamamoto Y, Yamamoto N, Mizobuchi Y, Mure H, Tada Y, Nakajima K, Okazaki T, Fujihara T
  • Organizer: 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY
  • Int'l Joint Research
• [Presentation] Pro-inflammatory Response Elicited by Porphyromonas Gingivalis Lipopolysaccharide Exacerbates the Rupture of Experimental Cerebral Aneurysms (2017)
  • Author(s): Miyamoto T, Kitazato K、Tada Y、Shimada K、Yagi K、 Korai、Maekawa H、Yamaguchi T、 Yoshioka S、 Kinouchi T、 Kanematsu Y、 Satomi J、Nagahiro S
  • Organizer: International Stroke Conference 2017
  • Int'l Joint Research
• [Presentation] Treatment strategy and outcom of ruptured vertebral artery dissecting aneurysms (2017)
  • Author(s): Korai M, Kanematsu Y, Tada Y, Yamaguchi I, Yamamoto N, Yamamoto Y, Satomi J
  • Organizer: 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY
  • Int'l Joint Research
• [Presentation] Crab claw sign predicts successful recanalization in acute mechanical thrombectomy (2017)
  • Author(s): Yamamoto Y, Yamamoto N, Izumi Y, Yamaguchi I, Korai M, Kanematsu Y, Satomi J, Nagahiro S, Kaji R
  • Organizer: 14TH CONGRESS OF THE WORLD FEDERATION OF INTERVENTIONAL AND THERAPEUTIC NEURORADIOLOGY
  • Int'l Joint Research
• [Presentation] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis (2016)
  • Author(s): 1)Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro
  • Organizer: 25th European Stroke Conference 2016
  • Place of Presentation: Italy(Venice)
  • Year and Date: 2016-04-13
  • Int'l Joint Research
• [Presentation] Porphyromonas gingivalis lipopolysaccharide enhances the rupture of intracranial aneurysms in rats (2016)
  • Author(s): T. Miyamoto, K.T. Kitazato, H. Maekawa, T. Yamaguchi, K. Shimada, K. Yagi, Y. Tada, Y. Kurashiki, S. Yoshioka, Y. Kanematsu, J. Satomi, S. Nagahiro
  • Organizer: 25th European Stroke Conference 2016
  • Place of Presentation: Italy(Venice)
  • Year and Date: 2016-04-13
  • Int'l Joint Research
• [Presentation] Activation of M2 macrophages in the late phase of cerebral ischema may contribute to phagocytosis of infract area and neurogenesis (2016)
  • Author(s): Y. Kurashiki, K.T. Kitazato, K. Shimada, K. Yagi, Y. Tada, T. Kinouchi, M. Sumiyoshi, T. Miyamoto, T. Yamaguchi, J. Satomi, Y. Uto, S. Nagahiro
  • Organizer: 25th European Stroke Conference
  • Place of Presentation: Venice, Italy
  • Year and Date: 2016-04-13
  • Int'l Joint Research
• [Presentation] Porphyromonas gingivalis lipopolysaccharide enhances the rupture of intracranial aneurysms in rats (2016)
  • Author(s): T. Miyamoto, K.T. Kitazato, H. Maekawa, T. Yamaguchi, K. Shimada, K. Yagi, Y. Tada, Y. Kurashiki, S. Yoshioka, Y. Kanematsu, J. Satomi, S. Nagahiro
  • Organizer: 25th European Stroke Conference
  • Place of Presentation: Venice, Italy
  • Year and Date: 2016-04-13
  • Int'l Joint Research
• [Presentation] Early Morphological Changes in Cerebral Arteries of Cerebral Aneurysm Rupture Model Rats (2016)
  • Author(s): H. Maekawa, T. Miyamoto, K.T. Kitazato, K. Yagi, Y. Tada, K. Shimada, J. Satomi, S. Nagahiro
  • Organizer: International Stroke Conference
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2016-02-17
  • Int'l Joint Research
• [Presentation] Impact of Periodontal Disease and －Bacteria on Intracranial Aneurysms (2016)
  • Author(s): S. Yoshioka, Y. Tada, J. Satomi, K. Yagi, K. Naruishi, K. Kuwayama, K. T. Kitazato, T. Miyamoto, Y. Kanematsu, M. Harada, T. Nagata, S. Nagahiro
  • Organizer: International Stroke Conference
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2016-02-17
  • Int'l Joint Research
• [Presentation] A Pilot Study of the Mineralocorticoid Receptor Blocker Eplerenone in Hypertensive Patients with Unruptured Cerebral Aneurysms (2016)
  • Author(s): J. Satomi, Y. Tada, Y. Kanematsu, K. Kuwayama, K. Yagi, T. Kinouchi, K. Nakajima, N. Matsushita, T. Miyamoto, T. Yamaguchi, M. Korai, H. Mure, K. T. Kitazato, S. Nagahiro
  • Organizer: International Stroke Conference
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2016-02-17
  • Int'l Joint Research