| Project/Area Number |
15K10319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Fujita Health University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | facial nucleus / retrograde degeneration / rat / facial nerve / abulsion injury / brainstem / avulsion injusry |
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| Outline of Final Research Achievements |
Mechanism for prevention of retrograde degeneration of facial motor neuron in the facial nucleus was analyzed by our novel intra-brainstem and intracisternal rat facial nerve injury models. As peripheral nerve graft into brainstem prevented the retrograde degeneration, Pregabalin (PGB), which is a Ca blockers (α2δ ligand), delayed the retrograde degeneration of the facial neuron in the intracisternal facial nerve avulsion model. The total viable neuron count was significantly greater in the PGB group than in the Control group. Furthermore, CD11b/c immunostaining showed that CD11b/c-positive cells, suggestive of activated microglia, were observed only in the control group (Moriya-S et al, J Neurosurg, Sci, 2017). Intraperitoneal injection of an immunosuppressive agent FK506, also suppressed the retrograde degeneration of facial motor neuron. Accordingly, immune process might play an important role for the retrograde degeneration of facial motor neurons.
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