| Project/Area Number |
15K10322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
賀耒 泰之 熊本大学, 医学部附属病院, 助教 (20626882)
広畑 優 久留米大学, 医学部, 教授 (40218863)
平井 俊範 宮崎大学, 医学部, 教授 (40274724)
河野 隆幸 熊本大学, 医学部附属病院, その他 (50448536)
青木 孝親 久留米大学, 医学部, 講師 (70330842)
安陪 等思 久留米大学, 医学部, 教授 (90167940)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | もやもや病 / MRI / arterial stenosis / cerebral infarction / 後大脳動脈 / 動脈狭窄 / 脳梗塞 / 血管収縮 / 血管病理 / バイパス手術 / 血管新生因子 |
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| Outline of Final Research Achievements |
The special MRI Imaging of CUBE image and CISS image of moyamoya disease patients have provided important informations; Cube image, which clearly showed the thickness of arterial wall, showed no thickening change in moyamoya disease patients. Furthermore, we compared the outer diameters of Internal cerebral aertery (ICA) and middle cerebral artery (MCA) after- and pre- bypass surgery (STA-MCA anastomosis). The diameters of both arteries obviously decreased after bypass. These data supported our hypothesis of “constrictive remodeling” of moyamoya disease artery. Detailed observation of DSA, showed the stenotic change of peripheral arteries of MCA, which suggested the constriction of arteries might occur even at peripheral branches in moyamoya disease patients. Although, no registered patient show the stenotic change at posterior cerebral artery, which might induce severe cerebral infarction, we plan to continue this registration study and careful observation.
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