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Early diagnosis and improvemnet of severe moyamoya disease patient outcime

Research Project

Project/Area Number 15K10322
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKurume University

Principal Investigator

Morioka Motohiro  久留米大学, 医学部, 教授 (20295140)

Co-Investigator(Kenkyū-buntansha) 賀耒 泰之  熊本大学, 医学部附属病院, 助教 (20626882)
広畑 優  久留米大学, 医学部, 教授 (40218863)
平井 俊範  宮崎大学, 医学部, 教授 (40274724)
河野 隆幸  熊本大学, 医学部附属病院, その他 (50448536)
青木 孝親  久留米大学, 医学部, 講師 (70330842)
安陪 等思  久留米大学, 医学部, 教授 (90167940)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsもやもや病 / MRI / arterial stenosis / cerebral infarction / 後大脳動脈 / 動脈狭窄 / 脳梗塞 / 血管収縮 / 血管病理 / バイパス手術 / 血管新生因子
Outline of Final Research Achievements

The special MRI Imaging of CUBE image and CISS image of moyamoya disease patients have provided important informations; Cube image, which clearly showed the thickness of arterial wall, showed no thickening change in moyamoya disease patients. Furthermore, we compared the outer diameters of Internal cerebral aertery (ICA) and middle cerebral artery (MCA) after- and pre- bypass surgery (STA-MCA anastomosis). The diameters of both arteries obviously decreased after bypass. These data supported our hypothesis of “constrictive remodeling” of moyamoya disease artery. Detailed observation of DSA, showed the stenotic change of peripheral arteries of MCA, which suggested the constriction of arteries might occur even at peripheral branches in moyamoya disease patients. Although, no registered patient show the stenotic change at posterior cerebral artery, which might induce severe cerebral infarction, we plan to continue this registration study and careful observation.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (11 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Stenotic changes of the posterior cerebral artery is a major contributing factor for cerebral infarction in moyamoya disease2018

    • Author(s)
      Ohkura A, Negoto T, Aoki T, Noguchi K, Okamoto Y, Komatani H, Kawano T, Mukasa A, Morioka M
    • Journal Title

      Surgical Neurosurgery International

      Volume: inpress

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 高齢者脳梗塞の現状と治療2018

    • Author(s)
      森岡基浩、青木孝親、宮城尚久
    • Journal Title

      Geriatric Neurosurgery

      Volume: 30 Pages: 35-39

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predictive value of leakage signs for pure brain contusional hematoma expansion2018

    • Author(s)
      Orito K, Hirohata M, Nakamura Y, Yamamoto M, Takeshige N, Aoki T, Hattori G, Sakata K, Takeuchi Y, Uzu H, Takasu O, Abe T, Uchiyama Y, Morioka M
    • Journal Title

      Journal of Neurotrauma

      Volume: 35 Issue: 5 Pages: 760-766

    • DOI

      10.1089/neu.2017.5247

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Symptomatic Brainstem Cavernoma of Elderly Patients: Timing and Strategy of Surgical Treatment. Two Case Reports and Review of the Literature2018

    • Author(s)
      Negoto T, Terachi S, Baba Y, Yamashita S, Kuramoto T, Morioka M
    • Journal Title

      World Neurosurg

      Volume: 111 Pages: 227-234

    • DOI

      10.1016/j.wneu.2017.12.111

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term Prognosis after Extracranial-intracranial Bypass Surgery for Symptomatic Cerebrovascular Occlusive Disease2017

    • Author(s)
      Komatani H, Okamoto Y, Aoki T, Noguchi K, Morioka M
    • Journal Title

      The Kurume Medical Journal

      Volume: 64 Issue: 1.2 Pages: 1-4

    • DOI

      10.2739/kurumemedj.MS6400016

    • NAID

      130006402990

    • ISSN
      0023-5679, 1881-2090
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bilateral Internal Carotid Artery Aneurysms at the Subpetrosal Portion with Unilateral Lower Cranial Nerve Palsies: Review and Consideration of Surgical Strategy.2017

    • Author(s)
      Noguchi K, Aoki T, Sakamoto R, Orito K, Takeuchi Y, Hirohata M, Morioka M.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 26 Issue: 4 Pages: e55-e59

    • DOI

      10.1016/j.jstrokecerebrovasdis.2016.12.033

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Comparative outcome analysis of anterior choroidal artery aneurysms treated with endovascular coiling or surgical clipping2016

    • Author(s)
      Aoki T, Hirohata M, Noguchi K, Komaki S, Orito K, Morioka M.
    • Journal Title

      Surg Neurol Int.

      Volume: 7(suppl 18) Issue: 19 Pages: 504-504

    • DOI

      10.4103/2152-7806.187492

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Leakage Sign for Primary Intracerebral Hemorrhage: A Novel Predictor of Hematoma Growth2016

    • Author(s)
      Orito K, Morioka M et al.
    • Journal Title

      Stroke

      Volume: 47 Issue: 4 Pages: 958-963

    • DOI

      10.1161/strokeaha.115.011578

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Alternatively Activated Macrophages Play an Important Role in Vascular Remodeling and Hemorrhaging in Patients with Brain Arteriovenous Malformation2015

    • Author(s)
      Nakamura Y , Morioka M et al.
    • Journal Title

      J Stroke Cerebrovasc

      Volume: 25 Issue: 3 Pages: 600-609

    • DOI

      10.1016/j.jstrokecerebrovasdis.2015.11.034

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 高齢者脳血管障害治療におけるFrailty Indexの提言2017

    • Author(s)
      森岡基浩
    • Organizer
      第30回日本老年脳神経外科学会(東京)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 重症頭蓋内圧亢進に対する新たなバルビツレート治療:Step down Infusion法の安全性と治療効果の検討(シンポジウム)2017

    • Author(s)
      森岡基浩
    • Organizer
      第23回日本脳神経モニタリング学会(東京)
    • Related Report
      2017 Annual Research Report
  • [Presentation] Leakage sign-a novel predictor for hemorrhage growth of primary intracerebral hemorrhage2017

    • Author(s)
      Morioka M, Orito K, Hirohata M, Aoki T
    • Organizer
      26th European Stroke Conference (Berlin)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Women neurosurgeons in a stroke care unit (Symposium)2017

    • Author(s)
      Morioka M
    • Organizer
      The 8th Congress of the International Society for Gender Medicine(Sendai)
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel indirect revascularization technique with preservation of temporal muscle function for moyamoya disease.2016

    • Author(s)
      Noguchi K, Aoki T, Sakamoto R, Orito K, Takeuchi Y, Hirohata M, Morioka M
    • Organizer
      14th Young-Honam and Kyushu Neurosurgical Joint Meeting
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Year and Date
      2016-11-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 造影CTを用いた出血増大予測因子としての造影剤漏出“Leakage sigh”の検討.2016

    • Author(s)
      折戸公彦、中村普彦、廣畑 優、安陪等思、森岡基浩
    • Organizer
      第75回日本脳神経外科学会総会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
  • [Presentation] Advantage of extended craniofacial resection for advanced malignant tumors of the nasal cavity and paranasal sinuses: Long-term outcome and surgical management2016

    • Author(s)
      Sakata K, Ono T, Koga N, Takeshige N, Rikimaru H, Umeno H, Kiyokawa K, Morioka M
    • Organizer
      7th International Congress of the World Federation of Skull Base Societies
    • Place of Presentation
      Bali (Indonesia)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 被殻出血に対する内視鏡下血腫除去術と開頭血腫除去術の比較検討.2016

    • Author(s)
      音琴哲也、寺地昭太、野口 慶、山本真文、中村普彦、折戸公彦、坂田清彦、青木孝親、廣畑 優、森岡基浩
    • Organizer
      第41回日本脳卒中学会総会
    • Place of Presentation
      ロイトン札幌(北海道札幌市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Direct clipping technique of IC-large/giant aneurysm.2016

    • Author(s)
      Morioka M
    • Organizer
      The 7th Japan-India Neurosurgical Conference
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Constrictive remodeling: Nobel pathophysiological hypothesis of Moyamoya disease2015

    • Author(s)
      Morioka M
    • Organizer
      14Th Asian Austrlasian Congress of Neurological Surgeons
    • Place of Presentation
      Jeju (Korea)
    • Year and Date
      2015-04-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] New indirect revascularization technique with preservation of temporal muscle function for Moyamoya Disease2015

    • Author(s)
      Noguchi K and Morioka M
    • Organizer
      14Th Asian Austrlasian Congress of Neurological Surgeons
    • Place of Presentation
      Jeju (Korea)
    • Year and Date
      2015-04-15
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] 虚血性中枢神経障害の基礎と臨床2016

    • Author(s)
      森岡基浩、廣畑 優、青木孝親、折戸公彦
    • Publisher
      真興交易
    • Related Report
      2016 Research-status Report
  • [Book] 脳神経外科 M&Mカンファランス2016

    • Author(s)
      森岡基浩
    • Publisher
      メジカルビュー社
    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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