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Translational research for cancer immunotherapy targeting glioblastoma initiating cells based on WT1 vaccination

Research Project

Project/Area Number 15K10331
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionOsaka University

Principal Investigator

Kagawa Naoki  大阪大学, 医学系研究科, 講師 (50444542)

Co-Investigator(Kenkyū-buntansha) 保仙 直毅  大阪大学, 医学系研究科, 寄附講座准教授 (10456923)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords腫瘍幹細胞 / 悪性神経膠腫 / 免疫逃避現象 / 分子標的治療 / 腫瘍血管正常化 / 免疫逃避 / WT1 / ALCAM / 腫瘍免疫 / 免疫療法
Outline of Final Research Achievements

We established research technique using animal model to study resistance to current therapies and immune escape phenomenon of cancer initiating cells in malignant gliomas. We can estimate effects of cancer immunotherapies in vivo by mouse glioma model. Histopathological and molecular cytologic study showed high expression of WT1 protein in glioblastoma initiating cells and higher expression of TGF-b, lower level of CD4-positive T lymphocyte and decreased expression in tumor samples of HLA class I in recurrent cases. Cancer immunotherapy combined with tumor vessel normalization factor induced lymphocyte distribution in glioblastomas and enhanced tumor suppressive effects in glioblastoma models. On based on these new findings, WT1 vaccination combined with molecular targeting therapies (immune check point inhibitors or tumor vessel normalization factors) can overcome immune escape phenomenon of cancer initiating cells and contribute to better clinical outcome for glioblastomas.

Academic Significance and Societal Importance of the Research Achievements

悪性神経膠腫は放射線治療や化学療法が奏功しにくい腫瘍であり、免疫療法や分子標的治療、それらの複合的治療を含めたカスタムメイドな治療戦略が、患者にとって福音をもたらす可能性がある。生体での免疫療法効果判定が可能なマウスグリオーマモデルの確立は、悪性神経膠腫の治療開発にとって重要な役割を有すると考えられる。この研究を基に、悪性神経膠腫幹細胞の治療抵抗性の解明とともに免疫逃避機構の一端を明らかにできる可能性が示唆される。また、我々が開発してきたWT1免疫療法に加えて、免疫チェックポイント阻害剤、TGFβ阻害剤、血管正常化因子などを組み合わせることにより、難治性の悪性神経膠腫の治療改善に貢献できる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (58 results)

All 2019 2018 2017 2016 2015 2014

All Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 20 results,  Open Access: 20 results,  Acknowledgement Compliant: 2 results) Presentation (37 results) (of which Int'l Joint Research: 10 results) Book (1 results)

  • [Journal Article] MicroRNA regulating stanniocalcin-1 is a metastasis and dissemination promoting factor in glioblastoma2019

    • Author(s)
      Sakata Junichi、Sasayama Takashi、Tanaka Kazuhiro、Nagashima Hiroaki、Nakada Mitsutoshi、Tanaka Hirotomo、Hashimoto Naoya、Kagawa Naoki、Kinoshita Manabu、Nakamizo Satoshi、Maeyama Masahiro、Nishihara Masamitsu、Hosoda Kohkichi、Kohmura Eiji
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 142 Issue: 2 Pages: 241-251

    • DOI

      10.1007/s11060-019-03113-2

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LPA4-Mediated Vascular Network Formation Increases the Efficacy of Anti-PD-1 Therapy against Brain Tumors2018

    • Author(s)
      Eino Daisuke、Tsukada Yohei、Naito Hisamichi、Kanemura Yonehiro、Iba Tomohiro、Wakabayashi Taku、Muramatsu Fumitaka、Kidoya Hiroyasu、Arita Hideyuki、Kagawa Naoki、Fujimoto Yasunori、Takara Kazuhiro、Kishima Haruhiko、Takakura Nobuyuki
    • Journal Title

      Cancer Research

      Volume: 78 Issue: 23 Pages: 6607-6620

    • DOI

      10.1158/0008-5472.can-18-0498

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of region-of-interest designs on quantitative measurement of multimodal imaging of MR non-enhancing gliomas2018

    • Author(s)
      Takano Koji、Kinoshita Manabu、Arita Hideyuki、Okita Yoshiko、Chiba Yasuyoshi、Kagawa Naoki、Watanabe Yoshiyuki、Shimosegawa Eku、Hatazawa Jun、Hashimoto Naoya、Fujimoto Yasunori、Kishima Haruhiko
    • Journal Title

      Oncology Letters

      Volume: 15 Pages: 7934-7940

    • DOI

      10.3892/ol.2018.8319

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A phase I clinical study of a cocktail vaccine of Wilms’ tumor 1 (WT1) HLA class I and II peptides for recurrent malignant glioma2018

    • Author(s)
      Tsuboi A, Hashimoto N, Fujiki F, Morimoto S, Kagawa N, Nakajima H, Hosen N, Nishida S, Nakata J, Morita S, Sakamoto J, Oji Y, Oka Y, Sugiyama H
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 68(2) Issue: 2 Pages: 331-340

    • DOI

      10.1007/s00262-018-2274-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 11C-methionine-18F-FDG dual-PET-tracer-based target delineation of malignant glioma: evaluation of its geometrical and clinical features for planning radiation therapy.2018

    • Author(s)
      Hirata T, Kinoshita M, Tamari, Seo Y, Suzuki O, Wakai N, Achiha T, Umehara T, Arita H, Kagawa N, Kanemura Y, Shimosegawa E, Hashimoto N, Hatazawa J, Kishima H, Teshima T, Ogawa K.
    • Journal Title

      Journal of Neurosurgery

      Volume: 21 Issue: 3 Pages: 1-11

    • DOI

      10.3171/2018.4.jns1859

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors.2018

    • Author(s)
      Fukuoka K, Kanemura Y, Makino K(26番目) et al.
    • Journal Title

      Acta neuropathologica communications

      Volume: 6 Issue: 1 Pages: 134-134

    • DOI

      10.1186/s40478-018-0630-1

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enchondromatosis-associated oligodendroglioma: case report and literature review2017

    • Author(s)
      Achiha Takamune、Arita Hideyuki、Kagawa Naoki、Murase Tsuyoshi、Ikeda Jun-ichiro、Morii Eiichi、Kanemura Yonehiro、Fujimoto Yasunori、Kishima Haruhiko
    • Journal Title

      Brain Tumor Pathology

      Volume: 35 Issue: 1 Pages: 36-40

    • DOI

      10.1007/s10014-017-0303-y

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Voxel-based lesion mapping of meningioma: a comprehensive lesion location mapping of 260 lesions2017

    • Author(s)
      Hirayama Ryuichi、Kinoshita Manabu、Arita Hideyuki、Kagawa Naoki、Kishima Haruhiko、Hashimoto Naoya、Fujimoto Yasunori、Yoshimine Toshiki
    • Journal Title

      Journal of Neurosurgery

      Volume: ― Issue: 6 Pages: 1-6

    • DOI

      10.3171/2017.3.jns17169

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic and Prognostic Value of 11C-Methionine PET for Nonenhancing Gliomas.2016

    • Author(s)
      Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Fujimoto Y, Kishima H, Kanemura Y, Nonaka M, Nakajima S, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T.
    • Journal Title

      AJNR Am J Neuroradiol

      Volume: 37 Issue: 1 Pages: 44-50

    • DOI

      10.3174/ajnr.a4460

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas2016

    • Author(s)
      Arita H, Yamasaki K, Matsushita Y, Nakamura T, Shimokawa A, Takami H, Tanaka S, Mukasa A, Shirahata M, Shimizu S, Suzuki K, Saito K, Kobayashi K, Higuchi F, Uzuka T, Otani R, Tamura K, Sumita K, Ohno M, Miyakita Y, Kagawa N, Hashimoto N, Hatae R, Yoshimoto K, Shinojima N, Nakamura H, Kanemura Y, Okita Y, et al.
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 4 Issue: 1 Pages: 79

    • DOI

      10.1186/s40478-016-0351-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.2016

    • Author(s)
      Oji Y, Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Elisseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H.
    • Journal Title

      Int J Cancer.

      Volume: 139 Issue: 6 Pages: 1391-401

    • DOI

      10.1002/ijc.30182

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Introduction of High Throughput Magnetic Resonance T2-Weighted Image Texture Analysis for WHO Grade 2 and 3 Gliomas.2016

    • Author(s)
      Kinoshita M, Sakai M, Arita H, Shofuda T, Chiba Y, Kagawa N, Watanabe Y, Hashimoto N, Fujimoto Y, Yoshimine T, Nakanishi K, Kanemura Y.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: e0164268-e0164268

    • DOI

      10.1371/journal.pone.0164268

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas.2016

    • Author(s)
      Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, Fujimoto Y, Yoshimine T
    • Journal Title

      J Neurosurg

      Volume: 印刷中 Issue: 5 Pages: 1136-1142

    • DOI

      10.3171/2015.11.jns151848

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.2016

    • Author(s)
      Thompson EM, Hielscher T, Bouffet E, Remke M, Luu B, Kagawa N, Hashimoto N, Jabado N, Shih DJ, Kijima N, Northcott PA, Kool M, Jones DT, Chan JA, Hawkins CE, Tabori U, Drake J, Kulkarni A, Dirks P, Rutka JT, Korshunov A, Pfister SM, Packer RJ, Ramaswamy V, Taylor MD.
    • Journal Title

      Lancet Oncol.

      Volume: 17(4) Issue: 4 Pages: 484-495

    • DOI

      10.1016/s1470-2045(15)00581-1

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of WT1 IgG antibody against WT1 peptide with prolonged survival in glioblastoma multiforme patients vaccinated with WT1 peptide.2016

    • Author(s)
      Oji Y, Naoya Hashimoto N, Tsuboi A, Murakami Y, Iwai M, Kagawa N, Chiba Y, Izumoto S, Eliseeva O, Ichinohasama R, Sakamoto J, Morita S, Nakajima H, Takashima S, Nakae Y, Nakata J, Kawakami M, Nishida S, Hosen N, Fujiki F, Morimoto S, Adachi M, Iwamoto M, Oka Y, Yoshimine T, Sugiyama H.
    • Journal Title

      Int J Cancer.

      Volume: -

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of diffusion tensor imaging and 11C-methionine positron emission tomography for reliable prediction of tumor cell density in gliomas.2016

    • Author(s)
      Kinoshita M, Arita H, Okita Y, Kagawa N, Kishima H, Hashimoto N, Tanaka H, Watanabe Y, Shimosegawa E, Hatazawa J, Fujimoto Y, Yoshimine T.
    • Journal Title

      J Neurosurg.

      Volume: - Pages: 1-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic and Prognostic Value of 11C-Methionine PET for Nonenhancing Gliomas.2016

    • Author(s)
      Takano K, Kinoshita M, Arita H, Okita Y, Chiba Y, Kagawa N, Fujimoto Y, Kishima H, Kanemura Y, Nonaka M, Nakajima S, Shimosegawa E, Hatazawa J, Hashimoto N, Yoshimine T.
    • Journal Title

      AJNR Am J Neuroradiol.

      Volume: 37(1) Pages: 44-50

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response2015

    • Author(s)
      Naoya Hashimoto, Akihiro Tsuboi, Naoki Kagawa, Yasuyoshi Chiba, Shuichi Izumoto, Manabu Kinoshita, Noriyuki Kijima, Yoshihiro Oka, Soyoko Morimoto, Hiroko Nakajima, Satoshi Morita, Junichi Sakamoto, Sumiyuki Nishida, Naoki Hosen, Yusuke Oji, Norio Arita, Toshiki Yoshimine, Haruo Sugiyama
    • Journal Title

      Cancer Immunology Immunotherapy

      Volume: - Issue: 6 Pages: 707-16

    • DOI

      10.1007/s00262-015-1674-8

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Peptide vaccination therapy against brain tumors2015

    • Author(s)
      Hashimoto N, Kagawa N, Arita H, Tsuboi A, Oka Y, Oji Y, Sugiyama H, Yoshimine T.
    • Journal Title

      Gan To Kagaku Ryoho.

      Volume: 42(6) Pages: 687-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3.Treatment outcomes using CyberKnife for brain metastases from lung cancer.2014

    • Author(s)
      Tamari K, Suzuki O, Hashimoto N, Kagawa N, Fujiwara M, Sumida I, Seo Y , Isohashi F, Yoshioka Y, Yoshimine T, Ogawa K.
    • Journal Title

      J Radiat Res

      Volume: - Issue: 1 Pages: 151-8

    • DOI

      10.1093/jrr/rru092

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Immunotherapy for malignant glioma in children: WT1 peptide vaccination and future direction2018

    • Author(s)
      Naoki Kagawa, Yoshiko Hashii, Syogo Fukuya, Takamune Achiha, Chisato Yokota, Takanori Fukunaga, Daisuke Eino, Hideyuki Arita, Yasuyoshi Chiba, Yasunori Fujimoto, Naoya Hashimoto, Haruo Sugiyama, Haruhiko Kishima
    • Organizer
      The 46th Annual Meeting of the International Society for Pediatric Neurosurgery
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Therapeutic strategies and problems for radiation-induced intracranial tumors after irradiation for pediatric cancers2018

    • Author(s)
      Naoki Kagawa, Chisato Yokota, Toru Umehara, Takamune Achiha, Takanori Fukunaga, Daisuke Eino, Shogo Fukuya, Yasuyoshi Chiba, Hideyuki Arita, Yasunori Fujimoto, Haruhiko Kishima
    • Organizer
      The 46th Annual Meeting of the International Society for Pediatric Neurosurgery
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Diagnostic exposure to low-dose radiation and spontaneous regression in intracranial germ cell tumors2018

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Shogo Fukuya, Chisato Yokota, Yasunori Fujimoto, Yasuyoshi Chiba, Daisuke Eino, Toru Umehara, Takanori Fukunaga, Manabu Kinoshita, Haruhiko Kishima
    • Organizer
      The 18th International Symposium on Pediatric Neuro-Oncology
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 小児がん治療経験者における放射線誘発腫瘍の治療戦略と問題点2018

    • Author(s)
      Naoki Kagawa, Chisato Yokota, Takamune Achiha, Toru Umehara, Hideyuki Arita, Yasunori Fujimoto, Haruhiko Kishima
    • Organizer
      第60回日本小児血液・がん学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小児びまん性脳幹部神経膠腫に対する外科的治療の意義と治療戦略2018

    • Author(s)
      香川尚己、横田千里、阿知波孝宗、永野大輔、福永貴典、梅原徹、有田英之、藤本康倫、貴島晴彦
    • Organizer
      第46回日本小児神経外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 小児第四脳室内腫瘍摘出時における神経機能温存のための手術アプローチと脳幹マッピング2018

    • Author(s)
      香川尚己、阿知波孝宗、横田千里、梅原徹、有田英之、福永貴典、永野大輔、藤本康倫、貴島晴彦
    • Organizer
      第46回日本小児神経外科学会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 初発膠芽腫におけるcarmustine wafers留置と再発時摘出後再留置の有効性と安全性2018

    • Author(s)
      香川尚己、橋本直哉、福屋章悟、相原英夫、篠山隆司、國枝武治、中田光俊、北井隆平、深井順也、木下学、金村米博、児玉良典、森田智視、阿知波孝宗、有田英之、藤本康倫、貴島晴彦
    • Organizer
      第36回日本脳腫瘍学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Immunotherapy of Wilms tumor 1 peptide vaccination against recurrent glioblastoma and diffuse intrinsic pontine glioma in children2017

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Yasuyoshi Chiba, Chisato Yokota, Takamune Achiha, Hideyuki Arita, Yasunori Fujimoto, Toshiki Yoshimine
    • Organizer
      Asian-Australasian Society for Pediatric Neurosurgery 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 母と子に発症した神経膠芽腫の病理組織像と分子遺伝学的検討2017

    • Author(s)
      香川尚己、阿知波孝宗、横田千里、有田英之、藤本康倫、貴島晴彦、森井英一、金村米博、中里洋一、吉峰俊樹
    • Organizer
      第35回日本脳腫瘍病理学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 第4脳室内腫瘍および脳幹腫瘍摘出時における神経機能温存: 手術アプローチの工夫と脳幹マッピング2017

    • Author(s)
      香川尚己、阿知波孝宗、横田千里、梅原徹、千葉泰良、有田英之、福永貴典、永野大輔、藤本康倫、貴島晴彦
    • Organizer
      第22回日本脳腫瘍の外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 小児悪性神経膠腫に対する免疫療法の課題と今後の展望2017

    • Author(s)
      香川尚己、橋井佳子、福屋章悟、阿知波孝宗、横田千里、福永貴典、永野大輔、有田英之、千葉泰良、藤本康倫、橋本直哉、杉山治夫、貴島晴彦
    • Organizer
      日本脳神経外科学会第76回学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 松果体実質腫瘍と頭蓋内胚細胞腫の画像による鑑別:腫瘍体積変化率による考察2017

    • Author(s)
      香川尚己、福屋章悟、藤本康倫、千葉泰良、横田千里、阿知波孝宗、永野大輔、福永貴典、梅原徹、有田英之、木下学、貴島晴彦
    • Organizer
      第35回日本脳腫瘍学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Hypersensitivity of intracranial germinomas for low-dose radiation: relationship between diagnostic radiation dose and volumetric changes before chemoradiotherapy2017

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Yasunori Fujimoto, Yasuyoshi Chiba, Chisato Yokota, Shogo Fukuya, Toshiki Yoshimine
    • Organizer
      Asian-Australasian Society for Pediatric Neurosurgery 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 治療前の診断時低線量被曝による頭蓋内胚細胞腫の体積変化2017

    • Author(s)
      香川尚己、平山龍一、福屋章悟、藤本康倫、有田英之、千葉泰良、横田千里、阿知波孝宗、永野大輔、福永貴典、梅原徹、木下学、貴島晴彦
    • Organizer
      第59回日本小児血液・がん学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 髄芽腫における放射線減量集学的治療後の長期生存者の神経心理学的評価とQuality of Life2017

    • Author(s)
      香川尚己、橋井佳子、千葉泰良、平山龍一、横田千里、有田英之、藤本康倫、橋本直哉、原純一、吉峰俊樹
    • Organizer
      第45回日本小児神経外科学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 第4脳室腫瘍に対するtranscerebellomedullary fissure approachの有用性2017

    • Author(s)
      香川尚己、有田英之、藤本康倫、貴島晴彦
    • Organizer
      第22回関西脳神経外科手術研究会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 小児脳神経外科における頭部固定:工夫と問題点2017

    • Author(s)
      香川尚己、横田千里、藤本康倫、有田英之、貴島晴彦
    • Organizer
      第35回日本こども病院神経外科医会
    • Related Report
      2017 Research-status Report
  • [Presentation] Immunotherapy of Wilms tumor 1 peptide vaccination improve prognosis of recurrent glioblastoma and diffuse intrinsic pontine glioma in children2017

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Yasuyoshi Chiba, Chisato Yokota, Takamune Achiha, Hideyuki Arita, Yasunori Fujimoto, Toshiki Yoshimine
    • Organizer
      SNO Pediatric Neuro-Oncology Basic and Translational Research Conference
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Blake's pouch cystを伴う水頭症に対する内視鏡的第3脳室窓術の治療成績と髄液循環病態に対する考察2017

    • Author(s)
      香川尚己、梅原徹、藤本康倫、阿知波孝宗、福永貴典、横田千里、永野大輔、有田英之、貴島晴彦
    • Organizer
      第24回日本神経内視鏡学会
    • Related Report
      2017 Research-status Report
  • [Presentation] 小児中枢神経系悪性腫瘍における当院での緩和医療の現状と取り組み2016

    • Author(s)
      香川尚己、平山龍一、横田千里、千葉泰良、有田英之、藤本康倫、橋本直哉、吉峰俊樹
    • Organizer
      第43回日本小児神経外科学会
    • Place of Presentation
      筑波
    • Year and Date
      2016-06-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 小児再発性神経膠芽腫およびび漫性橋神経膠腫に対するWT1ペプチドワクチン療法の安全性と有効性2016

    • Author(s)
      香川尚己、橋井佳子、千葉泰良、平山龍一、有田英之、藤本康倫、橋本直哉、杉山治夫、吉峰俊樹
    • Organizer
      第43回日本小児神経外科学会
    • Place of Presentation
      筑波
    • Year and Date
      2016-06-23
    • Related Report
      2015 Research-status Report
  • [Presentation] Immunotherapy of Wilms tumor 1 peptide vaccination against recurrent glioblastoma and diffuse intrinsic pontine glioma in children2016

    • Author(s)
      Kagawa N, Hashii Y, Hirayama R, Chiba Y, Miyamura T, Arita H, Fujimoto Y, Hashimoto N, Sugiyama H, Yoshimine Y
    • Organizer
      The 17th International Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Liverpool(UK)
    • Year and Date
      2016-06-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hypersensitivity of intracranial germinomas for low-dose radiation: relationship between diagnostic radiation dose and volumetric changes before chemoradiotherapy2016

    • Author(s)
      Kagawa N, Hirayama R, Fujimoto Y, Chiba Y, Yokota C, Fukuya S, Eino D, Takano K, Kinoshita M, Hashimoto N, Yoshimine Y
    • Organizer
      The 17th International Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Liverpool(UK)
    • Year and Date
      2016-06-13
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hypersensitivity of intracranial germinomas for low-dose radiation: relationship between diagnostic radiation dose and volumetric changes before chemoradiotherapy2016

    • Author(s)
      Naoki Kagawa, Ryuichi Hirayama, Yasunori Fujimoto, Yasuyoshi Chiba, Chisato Yokota, Shogo Fukuya, Daisuke Eino, Koji Takano, Manabu Kinoshita, Naoya Hashimoto and Toshiki Yoshimine
    • Organizer
      17th International Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Liverpool (United Kingdom)
    • Year and Date
      2016-06-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Immunotherapy of Wilms tumor 1 peptide vaccination against recurrent glioblastoma and diffuse intrinsic pontine glioma in children2016

    • Author(s)
      Naoki Kagawa, Yoshiko Hashii, Ryuichi Hirayama, Yasuyoshi Chiba, Takako Miyamura, Hideyuki Arita, Yasunori Fujimoto, Naoya Hashimoto, Haruo Sugiyama, Toshiki Yoshimine
    • Organizer
      17th International Symposium on Pediatric Neuro-Oncology
    • Place of Presentation
      Liverpool (United Kingdom)
    • Year and Date
      2016-06-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経膠芽腫における微小血管増生と分子マーカーとの関係についての考察2016

    • Author(s)
      香川尚己、永野大輔、有田英之、福屋章悟、高野浩司、福永貴典、平山龍一、藤本康倫、森井英一、吉峰俊樹
    • Organizer
      第34回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Year and Date
      2016-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 神経膠芽腫における微小血管増生と分子マーカーとの関係についての考察2016

    • Author(s)
      香川尚己、永野大輔、有田英之、福屋章悟、平山龍一、高野浩司、福永貴典、藤本康倫、森井英一、吉峰俊樹
    • Organizer
      第34回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] 小児再発性神経膠芽腫およびび漫性橋神経膠腫に対するWT1ペプチドワクチン療法の安全性と有効性2016

    • Author(s)
      香川尚己、橋井佳子、千葉泰良、平山龍一、有田英之、藤本康倫、橋本直哉、杉山治夫、吉峰俊樹
    • Organizer
      第44回日本小児神経外科学会
    • Place of Presentation
      筑波
    • Related Report
      2016 Research-status Report
  • [Presentation] 再発小児悪性神経膠腫に対するWT1ペプチドワクチン療法2016

    • Author(s)
      香川尚己, 橋井佳子, 橋本 直哉, 平山龍一, 千葉泰良, 有田英之, 藤本康倫,坪井昭博, 尾路祐介, 岡芳弘, 杉山治夫, 吉峰俊樹
    • Organizer
      一般社団法人日本脳神経外科学会第75回学術総会
    • Place of Presentation
      福岡
    • Related Report
      2016 Research-status Report
  • [Presentation] 再発小児悪性神経膠腫に対するWT1ペプチドワクチン療法の有効性と問題点2016

    • Author(s)
      香川尚己, 橋井佳子, 橋本 直哉, 平山龍一, 千葉泰良, 有田英之, 藤本康倫,坪井昭博, 尾路祐介, 岡芳弘, 杉山治夫, 吉峰俊樹
    • Organizer
      第34回日本脳腫瘍学会学術集会
    • Place of Presentation
      山梨
    • Related Report
      2016 Research-status Report
  • [Presentation] 頭蓋内胚細胞腫における腫瘍内免疫担当細胞と腫瘍縮小率との関係2016

    • Author(s)
      福屋章悟、香川尚己、平山龍一、横田千里、福永貴典、永野大輔、有田英之、藤本康倫、吉峰俊樹
    • Organizer
      第34回日本脳腫瘍学会学術集会
    • Place of Presentation
      山梨
    • Related Report
      2016 Research-status Report
  • [Presentation] 小児脳腫瘍治療後の放射線誘発頭蓋内腫瘍に関する検討2016

    • Author(s)
      横田千里、香川尚己、福屋章悟、永野大輔、福永貴典、阿知波孝宗、有田英之、藤本康倫、吉峰俊樹
    • Organizer
      第34回日本脳腫瘍学会学術集会
    • Place of Presentation
      山梨
    • Related Report
      2016 Research-status Report
  • [Presentation] 視床発生embryonal tumor with abundant neuropil and true rosettes(ETANTR)の病理所見と分子診断2016

    • Author(s)
      香川尚己、平山龍一、福屋章悟、横田千里、永野大輔、有田英之、藤本康倫、信澤純人、中里洋一、吉峰俊樹
    • Organizer
      第34回日本脳腫瘍病理学会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] 頭蓋内胚細胞腫の放射線感受性に関する後方視的検討-体積変化と被曝線量との関係-2015

    • Author(s)
      香川尚己、平山龍一、千葉泰良、藤本康倫、福屋章悟、永野大輔、高野浩司、福永貴典、横田千里、有田英之、木下学、橋本直哉、丸野元彦、吉峰俊樹
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Research-status Report
  • [Presentation] マウスグリオーマ脳腫瘍モデルを用いたWT1ペプチドワクチン療法の検討2015

    • Author(s)
      高野浩司、千葉泰良、中島博子、福永貴典、福屋章悟、永野大輔、平山龍一、有田英之、香川尚己、藤本康倫、橋本直哉、杉山治夫、吉峰俊樹
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 再発膠芽腫におけるベバシズマブ治療成績2015

    • Author(s)
      永野 大輔, 香川 尚己、福永 貴典, 福屋 章悟, 高野 浩司, 平山 龍一, 有田 英之,吉峰 俊樹
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2015-12-06
    • Related Report
      2015 Research-status Report
  • [Presentation] 他の小児がん診療と比較した際の小児脳腫瘍診療の集約化・均霑化の問題点2015

    • Author(s)
      香川尚己、吉峰俊樹、柳澤隆昭、原純一
    • Organizer
      第43回日本小児神経外科学会
    • Place of Presentation
      下関
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
  • [Book] スタンダード小児がん手術 臓器別アプローチと主義のポイント2017

    • Author(s)
      田口智章、黒田達夫
    • Total Pages
      313
    • Publisher
      MEDICAL VIEW社
    • Related Report
      2017 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2020-03-30  

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