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New BNCT against brain tumor stem cell with BSH-peptide

Research Project

Project/Area Number 15K10333
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionOkayama University

Principal Investigator

Michiue Hiroyuki  岡山大学, 中性子医療研究センター, 准教授 (20572499)

Co-Investigator(Renkei-kenkyūsha) KITAMATSU Mizuki  近畿大学, 理工学部, 講師 (60379716)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsホウ素中性子捕捉療法(BNCT) / ホウ素製剤 / 細胞膜通過ペプチド / 陽電子放射断層撮影( PET) / 悪性脳腫瘍 / 粒子線治療 / BNCT / ホウ素薬剤 / 創薬 / 膠芽腫 / 細胞内導入 / ペプチド
Outline of Final Research Achievements

We already succeeded to create new boron compound with cell penetrating peptide (CPP) for boron neutron capture therapy (BNCT). The CPP fused multi-BSH was synthesized in previous project, but it was very difficult to apply to high-volume synthesis for clinical use. In this time, we made up new BSH-CPP with possibility of clinical application and showed new boron drug imaging system for pharmacokinetic evaluation.
A) We made up BSH-3R with fused minimum number of CPP, 3R for clinical use. B) We observed intra-cellular localization of BSH-3R in human glioma cells and finally this boron compound localized at the nucleus of glioma cells. C) We created new positron emission tomography (PET) probe, BSH-3R-DOTA-64Cu. This BSH-3R-DOTA-64Cu was consisted of boron compound part (BSH), CPP part (3R), metal chelate part (DOTA, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and radioactive substance part (64Cu).

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(17 results)

All 2018 2017 2016 2015

All Journal Article Presentation Patent(Industrial Property Rights)

  • [Journal Article] Oxytocin inhibits corticosterone-induced apoptosis in primary hippocampal neurons2018

    • Author(s)
      Hein Min Latt, Hiroaki Matsushita, Miku Morino, Yuuri Koga, Hiroyuki Michiue, Teiichi Nishiki, Kazuhito Tomizawa, Hideki Matsui
    • Journal Title

      Neuroscience

      Volume: - Pages: 383-389

    • DOI
      10.1016/j.neuroscience.2018.03.025
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor 13 regulates glioma cell invasion and is important for bevacizumab-induced glioma invasion2017

    • Author(s)
      Otani Y、Ichikawa T、Kurozumi K、Inoue S、Ishida J、Oka T、Shimizu T、Tomita Y、Hattori Y、Uneda A、Matsumoto Y、Michiue H、Date I
    • Journal Title

      Oncogene

      Volume: 37 Pages: 777-786

    • DOI
      10.1038/onc.2017.373
    • Related Report
      2017 Annual Research Report
  • [Journal Article] PIK3R1Met326Ile germline mutation correlates with cysteine-rich protein 61 expression and poor prognosis in glioblastoma2017

    • Author(s)
      Otani Yoshihiro、Ishida Joji、Kurozumi Kazuhiko、Oka Tetsuo、Shimizu Toshihiko、Tomita Yusuke、Hattori Yasuhiko、Uneda Atsuhito、Matsumoto Yuji、Michiue Hiroyuki、Tomida Shuta、Matsubara Takehiro、Ichikawa Tomotsugu、Date Isao
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 7391-7391

    • DOI
      10.1038/s41598-017-07745-0
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of γH2AX foci in mouse normal brain and brain tumor after boron neutron capture therapy.2016

    • Author(s)
      Kondo N, Michiue H, Sakurai Y, Tanaka H, Nakagawa Y, Watanabe T, Narabayashi M, Kinashi Y, Suzuki M, Masunaga S, Ono K.
    • Journal Title

      Reports of Practical Oncology & Radiotherapy

      Volume: 21(2) Pages: 108-112

    • DOI
      10.1016/j.rpor.2014.10.005
    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization.2016

    • Author(s)
      Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei FY, Fujimura A, Tazawa H, Asai A, Ogo N, Miyachi H, Nishiki T, Tomizawa K, Takei K, Matsui H.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 1-12

    • DOI
      10.1038/srep23372
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Actin bundling by dynamin 2 and cortactin is implicated in cell migration by stabilizing filopodia in human non-small cell lung carcinoma cells.2016

    • Author(s)
      Yamada H, Takeda T, Michiue H, Abe T, Takei K.
    • Journal Title

      International Journal of Oncology

      Volume: 49(3) Pages: 877-86

    • DOI
      10.3892/ijo.2016.3592
    • NAID
      120006352349
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Enhancement of bone regeneration by dual release of a macrophage recruitment agent and platelet-rich plasma from gelatin hydrogels2015

    • Author(s)
      Arisaka Y, Kobayashi J, Yamato M, Akiyama Y, Okano T
    • Journal Title

      Biomaterials.

      Volume: 34 Pages: 214-224

    • NAID
      120005359212
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] The next generation Boron agents with BSH fused Cell Penetrating Peptide toward clinical application2017

    • Author(s)
      Hiroyuki Michiue, Mizuki Kitamatsu, Natsuko Kondo, Yoshinori Sakurai, Hideki Matsui
    • Organizer
      9th Young Researchers' BNCT Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 「現状の標準治療と課題、BNCTに対する期待」 -BNCTの悪性脳腫瘍・メラノーマへの応用-2017

    • Author(s)
      道上宏之
    • Organizer
      第1回 岡山大学中性子医療研究センターシンポジウム
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Anti-depressant, SSRI found by drug repositioning system, blocked glioblastoma invasion with targeting to inhibit actin polymerization2017

    • Author(s)
      Hiroyuki Michiue, Keiichiro Hayashi, Atsushi Fujimura, Hiroaki Matsushita, Tei-ichi Nishiki, Hideki Matsui
    • Organizer
      22ND ANNUAL SCIENTIFIC MEETING AND EDUCATION DAY
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗うつ薬フルボキサミンを用いた悪性グリオーマ治療法の開発2016

    • Author(s)
      道上宏之 林桂一郎 山田浩司 黒住和彦 市川智継 松下博昭 西木禎一 松井秀樹
    • Organizer
      第34回日本脳腫瘍学会学術大会
    • Place of Presentation
      山梨県甲府市
    • Year and Date
      2016-12-04
    • Related Report
      2016 Research-status Report
  • [Presentation] Fluvoxamine (SSRI), inhibits glioblastoma invasion by inhibition of actin polymerization2016

    • Author(s)
      Hiroyuki Michiue, Keiichiro Hayashi, Hirokazu Matsushita, Tei-ichi Nishiki, Hideki Matsui
    • Organizer
      European Association of Neuro-Oncology 2016
    • Place of Presentation
      Mannheim, Germany
    • Year and Date
      2016-10-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] New finding and functional analysis of Hypoxia-Induced Expression of Human Glioblastoma invasio2015

    • Author(s)
      Hiroyuki Michiue, Atsushi Fujimura, Hiroaki Matsushita, Tei-ichi Nishiki, Hideki Matsui
    • Organizer
      the Society for Neuro-Oncology 2015, San Antonio
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report
  • [Presentation] BSH-peptide delivery system and drug pharmacokinetics by positron emission tomography (PET) imaging2015

    • Author(s)
      Hiroyuki Michiue1 , Yoshiya Iguchi1, Mizuki Kitamatsu2, Hiroaki Matsushita1, Tei-ichi Nishiki1, Hideki Matsuil1
    • Organizer
      The8th Young Researchers BNCT Meeting
    • Place of Presentation
      Pavia, Italy
    • Year and Date
      2015-09-13
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Development of BSH Fused Cell-penetrating Peptide towards Clinical Application2015

    • Author(s)
      Hiroyuki Michiue1, Yoshiya Iguchi1, Mizuki Kitamatsu2, Hiroaki Matsushita1, Tei-ichi Nishiki1, Hideki Matsui1
    • Organizer
      International Congress of Radiation Research 2015
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Development of novel peptide BSH compound for accelerator based Boron Neutron Capture Therapy2015

    • Author(s)
      Hiroyuki Michiue1, Shin-ichi Miyatake3, Shinji Kawabata3, Yasuaki Ichikawa, Hideki Matsui1
    • Organizer
      International Congress of Radiation Research 2015
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2015-05-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Patent(Industrial Property Rights)] 細胞膜透過型ホウ素ペプチド2015

    • Inventor(s)
      道上宏之 松井秀樹
    • Industrial Property Rights Holder
      道上宏之 松井秀樹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-04-01
    • Application Year
      2015
    • Acquisition Date
      2016-09-23
    • Acquisition Year
      2016
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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