New BNCT against brain tumor stem cell with BSH-peptide
| Project/Area Number |
15K10333
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
Michiue Hiroyuki 岡山大学, 中性子医療研究センター, 准教授 (20572499)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAMATSU Mizuki 近畿大学, 理工学部, 講師 (60379716)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ホウ素中性子捕捉療法（BNCT） / ホウ素製剤 / 細胞膜通過ペプチド / 陽電子放射断層撮影（ PET） / 悪性脳腫瘍 / 粒子線治療 / ＢＮＣＴ / ホウ素薬剤 / 創薬 / 膠芽腫 / 細胞内導入 / ペプチド |
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| Outline of Final Research Achievements |
We already succeeded to create new boron compound with cell penetrating peptide (CPP) for boron neutron capture therapy (BNCT). The CPP fused multi-BSH was synthesized in previous project, but it was very difficult to apply to high-volume synthesis for clinical use. In this time, we made up new BSH-CPP with possibility of clinical application and showed new boron drug imaging system for pharmacokinetic evaluation.
A) We made up BSH-3R with fused minimum number of CPP, 3R for clinical use. B) We observed intra-cellular localization of BSH-3R in human glioma cells and finally this boron compound localized at the nucleus of glioma cells. C) We created new positron emission tomography (PET) probe, BSH-3R-DOTA-64Cu. This BSH-3R-DOTA-64Cu was consisted of boron compound part (BSH), CPP part (3R), metal chelate part (DOTA, 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) and radioactive substance part (64Cu).
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Detection of γH2AX foci in mouse normal brain and brain tumor after boron neutron capture therapy.2016
Author(s)
Kondo N, Michiue H, Sakurai Y, Tanaka H, Nakagawa Y, Watanabe T, Narabayashi M, Kinashi Y, Suzuki M, Masunaga S, Ono K.
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Journal Title
Reports of Practical Oncology & Radiotherapy
Volume: 21(2)
Pages: 108-112
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization.2016
Author(s)
Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei FY, Fujimura A, Tazawa H, Asai A, Ogo N, Miyachi H, Nishiki T, Tomizawa K, Takei K, Matsui H.
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Journal Title
Sci Rep
Volume: 6
Pages: 1-12
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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