| Project/Area Number |
15K10338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
HIRANO Hirofumi 鹿児島大学, 医歯学域医学系, 准教授 (00264416)
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| Co-Investigator(Kenkyū-buntansha) |
岸田 昭世 鹿児島大学, 医歯学域医学系, 教授 (50274064)
米澤 大 鹿児島大学, 医学部・歯学部附属病院, その他 (50550076)
内田 裕之 鹿児島大学, 医学部・歯学部附属病院, その他 (80404482)
有田 和徳 鹿児島大学, 医歯学総合研究科, 客員研究員 (90212646)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Wnt-5a / グリオーマ / 相互作用 / 免疫 / PD-L1 / 膠芽腫 / 生存期間 / マクロファージ / Wnt5a |
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| Outline of Final Research Achievements |
We studied the relationship between intratumoral expression of Wnt and expression of PDL-1 and therapeutic effect, but the correlation between Wnt5a and PD-L1 expression in glioblastoma was weak, and the expression level of PD-L1 in patients with glioblastoma did not show the difference in survival time.
In the analysis of Gene Expression Omnibus Database, there was PD-1 as a highly correlated gene candidate with Wnt-5a, but in vitro study the gene expression change related to immunosuppression of tumor cells by Wnt5a stimulation could not detected, and macrophage-mediated influence was no obvious in expression of immunity checkpoint-related genes.
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