Elucidation of radiation sensitization mechanism by hyperbaric oxygen therapy.
| Project/Area Number |
15K10339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
片桐 千秋 琉球大学, 医学(系)研究科(研究院), 助教 (00443664)
石内 勝吾 琉球大学, 医学(系)研究科(研究院), 教授 (10312878)
菅原 健一 琉球大学, 医学部附属病院, 講師 (50375573)
渡邉 孝 宮崎大学, 医学部, 講師 (90573337)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | グリオブラストーマ / 高気圧酸素療法 / 放射線照射 / 低酸素 / 脳腫瘍 / HBO / グリオブラストマ |
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| Outline of Final Research Achievements |
Hyperbaric oxygen treatment combined with radiation therapy improve radiation sensitivity on glioblastoma in our clinical data. In this study, we developed a xenograft animal model and investigated the influence of gene expression in the tumor contrarily in the radiation alone group and the hyperbaric oxygen therapy group on radiation sensitivity. Tet-on expression-inducing strain of tumor cell line U87-MG cells was constructed and induction of gene X expression after spheroid formation was also positive for pimonidazole, a hypoxic marker. It was suggested that gene X contributes to enhancement of radiosensitivity rather than involvement in hypoxia.
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Report
(4 results)
Research Products
(8 results)
