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Elucidation of radiation sensitization mechanism by hyperbaric oxygen therapy.

Research Project

Project/Area Number 15K10339
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Hideki Nagamine  琉球大学, 医学部, 助教 (30573331)

Co-Investigator(Kenkyū-buntansha) 片桐 千秋  琉球大学, 医学(系)研究科(研究院), 助教 (00443664)
石内 勝吾  琉球大学, 医学(系)研究科(研究院), 教授 (10312878)
菅原 健一  琉球大学, 医学部附属病院, 講師 (50375573)
渡邉 孝  宮崎大学, 医学部, 講師 (90573337)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsグリオブラストーマ / 高気圧酸素療法 / 放射線照射 / 低酸素 / 脳腫瘍 / HBO / グリオブラストマ
Outline of Final Research Achievements

Hyperbaric oxygen treatment combined with radiation therapy improve radiation sensitivity on glioblastoma in our clinical data. In this study, we developed a xenograft animal model and investigated the influence of gene expression in the tumor contrarily in the radiation alone group and the hyperbaric oxygen therapy group on radiation sensitivity. Tet-on expression-inducing strain of tumor cell line U87-MG cells was constructed and induction of gene X expression after spheroid formation was also positive for pimonidazole, a hypoxic marker. It was suggested that gene X contributes to enhancement of radiosensitivity rather than involvement in hypoxia.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (8 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] The usefulness of indocyanine green during surgery for hyper vascular posterior fossa tumors2018

    • Author(s)
      Shinya T, Nagamine H, SugawaraK, Ishiuchi S.
    • Journal Title

      Surgical Neurology International

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Radiation induced cellular hypoxic response is suppressed by hyperbalic oxygenation treatment.2017

    • Author(s)
      片桐千秋、長嶺英樹、圓谷智之、石内勝吾、松下正之
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      アクトシティ浜松(静岡県、浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Hyperbaric oxygenation treatment suppress radiotherapy induced cellular hypoxic response in glioblastoma.2017

    • Author(s)
      片桐千秋、長嶺英樹、松下正之、石内勝吾
    • Organizer
      第7回国際放射線神経生物学会大会
    • Place of Presentation
      越後湯沢温泉ホテル双葉 (新潟県、湯沢町)
    • Year and Date
      2017-02-09
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Neuroprotective effect of hyperbaric oxidation therapy2017

    • Author(s)
      Katagiri C
    • Organizer
      第40回日本神経科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effect of hyperbaric oxygenation treatment radiotherapy induced cellular hypoxic response in Glioblastoma.2016

    • Author(s)
      片桐千秋、長嶺英樹、松下正之、石内勝吾
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Hyperbaric oxygenation treatment prevent cellular hypoxic response by radiotherapy in glioblastoma.2016

    • Author(s)
      Chiaki Katagiri, Hideki Nagamine, Shogo Ishiuchi
    • Organizer
      The 6th International Society of Radiation Neurobiology Conference
    • Place of Presentation
      良順会館(長崎大学医学部坂本キャンパス)
    • Year and Date
      2016-02-12
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Hyperbaric oxygenation treatment effects on radioresponse in malignant glioblastoma.2015

    • Author(s)
      片桐千秋、長嶺英樹、石内勝吾
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-11-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Hyperbaric oxygenation treatment before radiotherapy improves radioresponse of Glioblastoma.2015

    • Author(s)
      片桐千秋
    • Organizer
      第58回日本神経化学会大会
    • Place of Presentation
      大宮ソニックシティ(埼玉県さいたま市)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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