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Biomarkers for evaluation of clinical activity of VEGFR-targeted vaccines against malignant glioma patients

Research Project

Project/Area Number 15K10344
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionKeio University

Principal Investigator

UEDA RYO  慶應義塾大学, 医学部(信濃町), 共同研究員 (30317143)

Co-Investigator(Renkei-kenkyūsha) TODA MASAHIRO  慶應義塾大学, 医学部, 准教授 (20217508)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords悪性神経膠腫 / 腫瘍抗原ペプチドワクチン / 脳腫瘍血管新生 / 脳腫瘍 / 免疫療法 / がんワクチン免疫療法 / 脳腫瘍血管新生性関連因子 / 抗腫瘍免疫応答抑制性因子 / 治療効果判定
Outline of Final Research Achievements

Evaluation of immunological biomarkers may lead to better understanding of the critical immune response indicators that may help to predict clinical responses of cancer immunotherapy. We characterized status of immune cells, cytokines, chemokines, and other immunosuppressive molecules in malignant glioma patients who received vaccinations of VEGF receptor (VEGFR)-derived peptides. Peripheral blood samples from patients who demonstrated positive radiologic response or stable disease revealed superior VEGFR-specific CTL reactivity and lower level of serum VEGF compared to samples from other patients with progressing malignant glioma. Plasma IL-8 level was negatively correlated with overall survival. These data indicate that these parameters may be potential immune-biomarkers for evaluation of clinical activity of VEGFR-targeted vaccines.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Book (1 results)

  • [Journal Article] A pilot study of peptide vaccines for VEGF receptor 1 and 2 in patients with recurrent/progressive high grade glioma2018

    • Author(s)
      Shunsuke Shibao, Ryo Ueda, Katsuya Saito, Ryogo Kikuchi, Hideaki Nagashima, Atsuhiro Kojima, Hiroshi Kagami, Eriel Sandika Pareira, Hikaru Sasaki, Shinobu Noji, Yutaka Kawakami, Kazunari Yoshida, and Masahiro Toda
    • Journal Title

      Oncotarget

      Volume: 印刷中

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 再発悪性神経膠腫に対するカクテルペプチドワクチン療法第1/2相臨床試験2016

    • Author(s)
      菊地亮吾、戸田正博、田村亮太、長島秀明、柴尾俊輔、齋藤克也、植田良、佐々木光、吉田一成
    • Organizer
      第34回日本脳腫瘍学会学術集会
    • Place of Presentation
      甲府富士屋ホテル
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] 巨大下垂体腺腫に対する治療方針の検討2016

    • Author(s)
      菊地亮吾、戸田正博、冨田俊樹、小澤宏之、秋山武和、植田 良、小川 郁
    • Organizer
      第26回日本間脳下垂体腫瘍学会
    • Place of Presentation
      ザ・セレクトン福島 (福島県福島市)
    • Year and Date
      2016-02-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 悪性神経膠腫に対するペプチドワクチン療法の臨床試験および新規標的抗原DEPDC1の解析2015

    • Author(s)
      菊地亮吾、戸田正博、長島秀明、柴尾俊介、齋藤克也、植田 良、サンペトラ オルテア、佐谷秀行、佐々木光、吉田一成
    • Organizer
      第33回日本脳腫瘍学会学術集会
    • Place of Presentation
      グランドプリンスホテル京都 (京都府京都市)
    • Year and Date
      2015-12-07
    • Related Report
      2015 Research-status Report
  • [Book] [図書] Annual Review 神経 2017 3.脳腫瘍  1脳腫瘍の免疫療法2017

    • Author(s)
      戸田正博
    • Total Pages
      5
    • Publisher
      中外医学社
    • Related Report
      2017 Annual Research Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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