Development of early judgment method of treatment effect by analysis using PET metabolism image for pre and post brain tumor treatment
Project/Area Number |
15K10345
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurosurgery
|
Research Institution | Osaka Medical College |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
川端 信司 大阪医科大学, 医学部, 准教授 (20340549)
古瀬 元雅 大阪医科大学, 医学部, 准教授 (70340560)
|
Project Period (FY) |
2015-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | PET / 悪性神経膠腫 / 放射線壊死 / 画像解析 / 画像診断 / 治療効果 |
Outline of Final Research Achievements |
The amino acid PET (FBPA-PET) using boron phenylalanine as a tracer is useful in determining the therapeutic effect of post brain tumor treatment. For FBPA-PET images of pre and post brain tumor treatment, we examined the transition of the results of analysis during the observation period, and at which stage it was possible to determine the therapeutic effect. Detection of useful parameters and calculation of cutoff for the PET images at each time point were performed using the analysis method that is prototyped and used in this research. We established the method of evaluation of treatment effects using FBPA-PET, and showed the usefulness to carry out the effect evaluation from the change over time using quantitative parameters.
|
Academic Significance and Societal Importance of the Research Achievements |
本研究成果は悪性脳腫瘍の経過観察に有用であるばかりでなく、良性病変に対しても、画像による経過観察期間の短縮または延長の判断や、治療無効例に対する早期外科療法の適応判断などに応用可能で、医療の向上および経済効果においても特に有効となる。 治療効果の早期判定は癌治療において重要な課題であり、治療後早期に効果判定がなされればその後の無意味な治療の継続が防止可能となり、患者への肉体的負担の軽減や医療経済上も有益となる。また、治療無効時のその後の治療のタイミングを遅らせることなく新規または別のプロトコールでの加療を行うことができる。
|
Report
(5 results)
Research Products
(23 results)
-
-
-
-
-
-
-
-
[Presentation] 原子炉を中性子源としたホウ素中性子捕捉療法による悪性神経膠腫の治療成績と加速器中性子源への移行2017
Author(s)
川端信司, 宮武伸一, 平松亮, 二村元, 竹内孝治, 斯波宏行, 金光拓也,松下葉子, 池田直廉, 野々口直助, 古瀬元雅, 田中浩基, 櫻井良憲,鈴木実, 小野公二, 黒岩敏彦
Organizer
日本脳神経外科学会第76回学術総会
Related Report
-
-
-
[Presentation] REACTOR-BASED BORON NEUTRON CAPTURE THERAPY (BNCT) FOR THE PATIENTS WITH RECURRENT MALIGNANT GLIOMA2017
Author(s)
S. Kawabata, R. Hiramatsu, Y. Matsushita, G. Futamura, T. Kanemitsu, H. Shiba, K. Takeuchi, N.Nonoguchi, T. Kuroiwa, H. Tanaka, Y. Sakurai, K. Akita, M. Suzuki, K. Ono, S.I. Miyatake
Organizer
XXIII World Congress of Neurology
Related Report
Int'l Joint Research
-
-
-
-
[Presentation] Clinical results of reactor-based BNCT using BPA for the patients with recurrent malignant glioma2016
Author(s)
Kawabata S, Hiramatsu R, Takeuchi K, Shiba H, Matsushita Y, Kuroiwa T, Tanaka H, Sakurai Y, Suzuki M, Ono K, Miyatake SI
Organizer
17th International Congress on Neutron Capture Therapy
Place of Presentation
University of Missouri, Missouri, USA
Year and Date
2016-10-02
Related Report
-
-
-
[Presentation] Boron neutron capture therapy for high-grade skull base meningioma2016
Author(s)
Takeuchi k, Kawabata S, Hiramatsu R, Matsushita Y, Kuroiwa T, Tanaka H, Sakurai Y, Suzuki M, Ono K, Miyatake SI
Organizer
7th International Congress of the World Federation of Skull Base Societies
Place of Presentation
Osaka International Convention Centre, Osaka
Year and Date
2016-06-14
Related Report
-
-
-
-
-