Elucidation of the M2 macrophage in brain metastases from lung cancer

• Project/Area Number: 15K10347
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Kindai University
• Principal Investigator: OKUDA TAKESHI 近畿大学, 医学部, 講師 (10340796)
• Co-Investigator(Kenkyū-buntansha): 藤田 貢 近畿大学, 医学部, 准教授 (40609997) ; 中田 晋 京都薬科大学, 薬学部, 准教授 (80590695)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 転移性脳腫瘍 / M2マクロファージ / 肺がん / 免疫療法 / 脳転移

Outline of Final Research Achievements

It was recognized that the immune system mainly on the M2 macrophage participated in mechanism of the metastasis to brain onset in the lung cancer. Furthermore, I was able to identify the gene cluster which could become the treatment target of this M2 macrophage in microarray analysis. In addition, this immunoresponse proved that the metabolism product which intestinal bacteria produced participated. The possibility that a new treatment strategy to prevent metastasis to brain was provided was suggested in future.

Research Products

• [Journal Article] Efficacy of Combination Therapy with MET and VEGF Inhibitors for MET-overexpressing Glioblastoma. (2017)
  • Author(s): Takeshi Okuda, Takayuki Tasaki, Susumu Nakata, Kimihiro Yamashita, Hiromasa Yoshioka, Shuichi Izumoto, Amami Kato, Mitsugu Fujita.
  • Journal Title: Anticancer Research Volume: 37 Issue: 7 Pages: 3871-3876
  • DOI: 10.21873/anticanres.11767
  • Peer Reviewed / Open Access
• [Journal Article] Surgical Site Infection after Malignant Brain Tumor Resection: A Multicenter Study for Induction of a Basic Care Bundle (2017)
  • Author(s): Uzuka T, Takahashi H, Nakasu Y, Okuda T, Mitsuya K, Hayashi N, Hirose T, Kurai H
  • Journal Title: Neurologia medico-chirurgica Volume: 57 Issue: 10 Pages: 542-547
  • DOI: 10.2176/nmc.oa.2017-0034
  • NAID: 130006882476
  • ISSN: 0470-8105, 1349-8029
  • Peer Reviewed / Open Access
• [Journal Article] A nationwide multi-institutional retrospective study to identify prognostic factors and develop a graded prognostic assessment system for patients with brain metastases from uterine corpus and cervical cancer (2017)
  • Author(s): Hayashi N, Takahashi H, Hasegawa Y, Higuchi F, Takahashi M, Makino K, Takagaki M, Akimoto J, Okuda T, Okita Y, Mitsuya K, Hirashima Y, Narita Y,Nakasu Y
  • Journal Title: BMC Cancer Volume: 17 Issue: 1 Pages: 397-397
  • DOI: 10.1186/s12885-017-3358-6
  • Peer Reviewed / Open Access
• [Journal Article] MET Expressed in Glioma Stem Cells Is a Potent Therapeutic Target for Glioblastoma Multiforme (2016)
  • Author(s): Tasaki T, Fujita M, Okuda T, Yoneshige A, Nakata S, Yamashita K, Yoshioka H, Izumoto S, Kato A
  • Journal Title: Anticancer Research Volume: 36 Pages: 3571-3577
  • Peer Reviewed
• [Journal Article] Clinical outcome of node-negative oligometastatic non-small cell lung cancer (2016)
  • Author(s): Sakai K, Takeda M, Hayashi H, Tanaka K, Okuda T, Nishimura Y, Mitsudomi T, Koyama A, Nakagawa K
  • Journal Title: Thoracic Oncology Volume: 7 Issue: 1 Pages: 670-675
  • DOI: 10.1016/j.jtho.2016.11.1218
  • Peer Reviewed
• [Journal Article] 胸膜に血行性転移をきたした膠芽腫の1例 (2015)
  • Author(s): 田崎貴之、奥田武司、岡本邦男、吉岡宏真、藤田貢、泉本修一、中川和彦、加藤天美
  • Journal Title: 脳神経外科ジャーナル Volume: 24(3) Pages: 192-197
  • NAID: 130005129850
  • Peer Reviewed / Open Access
• [Journal Article] 長期的予後を視野に入れた転移性脳腫瘍の治療戦略～分子標的薬の役割 (2015)
  • Author(s): 奥田武司
  • Journal Title: 脳神経外科速報 Volume: 25 Pages: 1307-1315
  • Open Access