| Project/Area Number |
15K10351
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
鎌田 恭輔 旭川医科大学, 医学部, 教授 (80372374)
野呂 昇平 旭川医科大学, 医学部, 助教 (50762720)
|
|---|
| Research Collaborator |
NORO Shouhei
|
|---|
| Project Period (FY) |
2015-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | Arterial Spin Labeling / functional MRI / functional mapping / Arterial Spin Labeling / fMRI / 脳機能局在 / ASL / ｆMRI / 言語機能局在 / 運動機能局在 / 記憶機能局在 |
|---|
| Outline of Final Research Achievements |
Brain function localization in motor tasks, language tasks, and memory tasks were detected using called Arterial Spin Labeling (ASL), and its consistency was verified by functional MRI (fMRI), which is currently the gold standard technique. The detection rate of ASL was lower than that of fMRI in motor task and speech task. However, it was suggested that ASL could detect more accurate functional localization. The memory task was difficult to detect with both ASL and fMRI. We are considering changing data acquisition method.
|
| Academic Significance and Societal Importance of the Research Achievements |
ALSによる脳機能局在の検出率はfMRIと比べて若干劣るものの、データ取得の時間や機能局在の位置情報の正確性ではfMRIに勝るものであったと考えられる。現在、最も信頼できる脳機能局在同定方法は、直接脳を刺激して確かめる電気生理学的な脳機能マッピングである。これは侵襲的な方法であり、時間と労力を要する。今後、ASLと脳機能マッピングの整合性の検証が必要であるが、ASLはこれに替わる脳機能局在同定方法となりうる可能性があり、安全な手術に貢献できると考えられる。
|
