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The efficacy of deep brain stimulation on gross motor and precise finger motor in monkey Parkinson's disease models, a PET study

Research Project

Project/Area Number 15K10358
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Asakawa Tetsuya  浜松医科大学, 医学部, 特任助教 (00469917)

Co-Investigator(Kenkyū-buntansha) 杉山 憲嗣  浜松医科大学, 医学部, 准教授 (00235904)
鈴木 勝昭  浜松医科大学, 医学部, 准教授 (00285040)
Research Collaborator Namba Hiroki  
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsパーキンソン病 / 脳深部電気刺激術 / 粗大運動 / 微細運動 / サルモデル / 分子イメージング研究 / PET / 神経回路 / パーキンソン氏病 / 行動判定テスト / PET / 脳血流
Outline of Final Research Achievements

We believe the principles of objectification, multi-purpose and simplification (OMS) will be the trend in future experimental design for behavioral assessments in the PD subjects. Based on the principles of OMS, we published many articles regarding the behavioral tests on movement disorders in Children and the behavioral tests using the newest IT techniques, such as wearable sensors, virtual reality (VR) and augmented reality (AR) technologies and robot assistant technology. We finished developing a new gripping test (GT) for measuring the precise finger motor for PD monkey model and human patients. The efficacy of deep brain stimulation for the precise finger motor was verified using GT and molecular image studies (positron emission tomography PET studies). Now we are analyzing these PET data.

Academic Significance and Societal Importance of the Research Achievements

本研究はサルPDモデル用の微細運動を計測できるGripping test(GT)を開発できた。この行動判定テストと分子イメージング技術を活用して、PD状態でのSTN-DBSにおける効果発現に関わる神経回路を同定し、粗大運動と微細運動の制御の神経回路の差異の解明できる。更にこの結果を受けて、微細運動の治療効果は粗大運動より弱い原因を究明し、臨床的に微細運動障害に対する最適なDBSターゲットとパラメーターを決定する方法を確立する。これらの成果は、現在行われているSTN-DBS治療に対してより効果的な刺激法に関する知見を提供し、治療ガイドラインの作成の際に有用となり得る。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (34 results)

All 2019 2018 2017 2016 2015

All Journal Article (24 results) (of which Int'l Joint Research: 19 results,  Peer Reviewed: 24 results,  Open Access: 16 results,  Acknowledgement Compliant: 3 results) Presentation (9 results) (of which Int'l Joint Research: 7 results,  Invited: 7 results) Book (1 results)

  • [Journal Article] An in vitro validation of the therapeutic effects of Tougu Xiaotong capsule on tunicamycin-treated chondrocytes2019

    • Author(s)
      Liang W, Li X, Hu L, Ding S, Kang J, Shen J, Zheng C, Li C, Ye H, Asakawa T*
    • Journal Title

      J Ethnopharmacol

      Volume: 229 Pages: 215-221

    • DOI

      10.1016/j.jep.2018.10.022

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Can the Latest Computerized Technologies Revolutionize Conventional Assessment Tools and Therapies for a Neurological Disease? The Example of Parkinson’s Disease2019

    • Author(s)
      Asakawa T, Sugiyama K, Nozaki T, Sameshima T, Kobayashi S, Wang L, Hong Z, Chen S, Li C, Namba H
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 59 Issue: 3 Pages: 69-78

    • DOI

      10.2176/nmc.ra.2018-0045

    • NAID

      130007612818

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Changes in striatal dopamine transporter and tyrosine hydroxylase expression associated with fatigue and their reversal by blueberry juice2019

    • Author(s)
      Jiang B, Zheng S, An L, Guo, J, Asakawa T*
    • Journal Title

      J of Berry Res

      Volume: 9 Issue: 2 Pages: 1-12

    • DOI

      10.3233/jbr-180350

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effect of Subthalamic Deep Brain Stimulation on Upper Limb Dexterity in Patients with Parkinson Disease.2018

    • Author(s)
      Nozaki T, Asakawa T, Sugiyama K, Koda Y, Shimoda A, Mizushima T, Sameshima T, Namba H.
    • Journal Title

      World Neurosurg.

      Volume: 115 Pages: e206-e217

    • DOI

      10.1016/j.wneu.2018.04.014

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genomic subtypes of GISTs for stratifying patient response to sunitinib following imatinib-resistance: a pooled-analysis and systematic review.2018

    • Author(s)
      Tan S, Chen P, Ji J, Guo S, Yu D, Asakawa T, Zhou Y, Abe M, Zong L.
    • Journal Title

      Dis Markers

      Volume: 2018:1368617 Pages: 1368617-1368617

    • DOI

      10.1155/2018/1368617

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deep Brain Stimulation for Intractable Obsessive-compulsive Disorder: The International and Japanese Situation/Scenario2018

    • Author(s)
      Sugiyama K, Nozaki T, Asakawa T, Sameshima T, Koizumi S, Hiramatsu H, Namba H.
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 58 Issue: 9 Pages: 369-376

    • DOI

      10.2176/nmc.st.2018-0115

    • NAID

      130007484382

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current behavioral assessments of movement disorders in children.2018

    • Author(s)
      Asakawa T, Sugiyama K, Nozaki T, Sameshima T, Kobayashi S, Wang L, Hong Z, Chen SJ, Li CD, Ding D, Namba H.
    • Journal Title

      CNS Neurosci Ther.

      Volume: 24 Issue: 10 Pages: 863-875

    • DOI

      10.1111/cns.13036

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evidence for the Use of Acupuncture in Treating Parkinson's Disease: Update of Information From the Past 5 Years, a Mini Review of the Literature2018

    • Author(s)
      Jiang F, Yang T, Yin H, Guo Y, Namba H, Sun Z, Asakawa T*
    • Journal Title

      Front Neurol

      Volume: 9 Pages: 596-596

    • DOI

      10.3389/fneur.2018.00596

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sirt1/Foxo Axis Plays a Crucial Role in the Mechanisms of Therapeutic Effects of Erzhi Pill in Ovariectomized Rats2018

    • Author(s)
      Liang W, Li X, Li G, Hu L, Ding S, Kang J, Shen J, Li C*. Asakawa T*
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: Aug 26 Issue: 1 Pages: 9210490-9210490

    • DOI

      10.1155/2018/9210490

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Confirming the Effects of Qinghuayin against Chronic Atrophic Gastritis, and a Preliminary Observation of the Involved Inflammatory Signaling Pathways: An in Vivo Study2018

    • Author(s)
      Li S, Huang M, Chen Q, Li S, Wang X, Lin J, Zhong G, Lin P*, Asakawa T*
    • Journal Title

      Evid Based Complement Alternat Med

      Volume: Sep 26 Issue: 1 Pages: 4905089-4905089

    • DOI

      10.1155/2018/4905089

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Role of Angle in the Evaluation of Ablation Accuracy in Pulmonary Vein Isolation Navigated by Image Integration2018

    • Author(s)
      Song-Wen Chen, Li-Dong Cai, Tetsuya Asakawa*, Gen-Qing Zhou, Yong Wei, Bao-Zhen Qi, Zhi-Yu Ling, Hai-Qing Wu, Juan Xu, Shao-Wen Liu*
    • Journal Title

      The Heart Surgery Forum

      Volume: 21 Issue: 6 Pages: E438-E442

    • DOI

      10.1532/hsf.2231

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synergistic Effect of Baicalin and Adriamycin in Resistant HL-60/ADM Leukaemia Cells2017

    • Author(s)
      Zheng Jing, Asakawa Tetsuya, Chen Yingyu, Zheng Zhihong, Chen Buyuan, Lin Minhui, Liu Tingbo and Hu Jianda*
    • Journal Title

      Cell Physiol Biochem

      Volume: 43 Issue: 1 Pages: 419-430

    • DOI

      10.1159/000480420

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Psychometric evaluation of the Chinese version of the revised American Pain Society Patient Outcome Questionnaire concerning pain management in Chinese orthopedic patients2017

    • Author(s)
      Fang Huan, Liang Jingjuan, Hong Zhen, Sugiyama Kenji, Nozaki Takao, Kobayashi Susumu, Sameshima Tetsuro, Namba Hiroki and Asakawa Tetsuya*
    • Journal Title

      PloS one

      Volume: 12 Issue: 5 Pages: e0178268-e0178268

    • DOI

      10.1371/journal.pone.0178268

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multifaceted interventions for improving spontaneous reporting of adverse drug reactions in a general hospital in China2017

    • Author(s)
      Fang Huan, Lin Xiaowen, Zhang Jun, Hong Zhen, Sugiyama Kenji, Nozaki Takao, Sameshima Tetsuro, Kobayashi Susumu, Namba Hiroki and Asakawa Tetsuya*
    • Journal Title

      BMC Pharmacology and Toxicology

      Volume: 18 Issue: 1 Pages: 49-49

    • DOI

      10.1186/s40360-017-0159-0

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Unmet challenges for rehabilitation after stroke in China2017

    • Author(s)
      Asakawa Tetsuya*, Zong Liang, Wang Liang, Xia Ying and Namba Hiroki
    • Journal Title

      The Lancet

      Volume: 390 Issue: 10090 Pages: 121-122

    • DOI

      10.1016/s0140-6736(17)31584-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of neuroserpin on clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke2017

    • Author(s)
      Wu Weiwen, Asakawa Tetsuya*, Yang Qianghong, Zhao Jun, Lu Lixia, Luo Yunhe, Gong Ping, Han Sha, Li Wei, Namba Hiroki and Wang Liang *
    • Journal Title

      Neurological research

      Volume: 39 Issue: 10 Pages: 862-868

    • DOI

      10.1080/01616412.2017.1357780

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neuroprotective effect of neuroserpin in non-tPA-induced intracerebral hemorrhage mouse models2017

    • Author(s)
      Li Wei, Asakawa Tetsuya*, Han Sha, Xiao Baoguo, Namba Hiroki, Lu Chuanzhen, Dong Qiang and Wang Liang*
    • Journal Title

      BMC Neurology

      Volume: 17 Issue: 1 Pages: 196-196

    • DOI

      10.1186/s12883-017-0976-1

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fluoxetine Increases the Expression of miR-572 and miR-663a in Human Neuroblastoma Cell Lines.2016

    • Author(s)
      Mundalil Vasu M, Anitha A, Takahashi T, Thanseem I, Iwata K, Asakawa T, Suzuki K.
    • Journal Title

      PLoS ONE

      Volume: 11 Issue: 10 Pages: e0164425-e0164425

    • DOI

      10.1371/journal.pone.0164425

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Human Behavioral Assessments in Current Research of Parkinson's Disease.2016

    • Author(s)
      Asakawa T, Fang H, Sugiyama K, Nozaki T, Kobayashi S, Hong Z, Suzuki K, Mori N, Yang Y, Hua F, Ding G, Wen G, Namba H, Xia Y.
    • Journal Title

      Neurosci Biobehav Rev

      Volume: Jun 29 Pages: 1-20

    • DOI

      10.1016/j.neubiorev.2016.06.036

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Animal behavioral assessments in current research of Parkinson's disease2016

    • Author(s)
      Asakawa T*, Fang H, Sugiyama K, Nozaki T, Hong Z, Yang Y, Hua F, Ding G, Chao D, Fenoy AJ, Villarreal SJ, Onoe H, Suzuki K, Mori N, Namba H, Xia Y*.
    • Journal Title

      Neurosci Biobehav Rev

      Volume: 65 Pages: 63-94

    • DOI

      10.1016/j.neubiorev.2016.03.016

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neuroserpin protects rat neurons and microglia-mediated inflammatory response against oxy-genglucose deprivation- and reoxygenation treatments in an in vitro study2016

    • Author(s)
      Yang X, Asakawa T*, Han S, Liu L, Wu W, Luo Y, Cao W, Cheng X, Xiao B, Namba H, Lu C, Dong Q, Wang L.
    • Journal Title

      Cell Physiol Biochem

      Volume: 38 Issue: 4 Pages: 1472-1482

    • DOI

      10.1159/000443089

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effects of Intracerebral Hemorrhage on 5-hydroxymethylcytosine Modification in Mouse Brain2016

    • Author(s)
      Tang Y, Han S, Asakawa T, Luo Y, Han X, Xiao B, Dong Q, Lu C, Wang L*
    • Journal Title

      Neuropsychiatr Dis Treat

      Volume: 12 Pages: 617-624

    • DOI

      10.2147/ndt.s97456

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neuroprotective effect of neuroserpin in oxygen-glucose deprivation- and reoxygenation-treated rat astrocytes in vitro2015

    • Author(s)
      Wang L*, Zhang Y, Asakawa T*, Li W, Han S, Li Q, Xiao B, Namba H, Lu C, Dong Q
    • Journal Title

      PLOS ONE

      Volume: 10 Issue: 4 Pages: e0123932-e0123932

    • DOI

      10.1371/journal.pone.0123932

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The Present Indication and Future of Deep Brain Stimulation2015

    • Author(s)
      Sugiyama K*, Nozaki T, Asakawa T, Koizumi S, Saito O , Namba H
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 55 Issue: 5 Pages: 416-421

    • DOI

      10.2176/nmc.ra.2014-0394

    • NAID

      130005069874

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Rehabilitation After Stroke, the Viewpoints From Japan2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      the 4th TCM master forum
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Current state of TCM in Japan2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      The 5th annual meeting of World Federation of Chinese Medicine Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The strategy of “Deep Brain Stimulation” for treating Parkinson’s disease in non-human primate animals2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      The 5th DBS Think Tank
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Principles of OMS during behavioral tests for Parkinson’s disease2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      Workshop for Parkinson’s disease & Movement Disorders
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Behavioral tests for Parkinson’s disease2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      The 1th annual meeting of Chinese Rehabilitation Society for Parkinson’s disease & Movement Disorders
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Principles of behavioral tests for symptom evaluation, an example of Parkinson’s disease----insights from animal to human being2018

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      The 5th annual meeting of World Federation of Chinese Medicine Societies
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rehabilitation after stroke in China, the roles of traditional Chinese medicine2017

    • Author(s)
      Tetsuya Asakawa
    • Organizer
      The 4th annual meeting of World Federation of Chinese Medicine Societies
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Neuroserpinの虚血時の脳細胞における神経保護作用2015

    • Author(s)
      浅川哲也, 杉山憲嗣, 野崎孝雄, 小林奨, 王亮, 張揚, 楊雪蓮, 鈴木勝昭, 難波宏樹,森則夫
    • Organizer
      第42回日本脳科学会、宮崎
    • Place of Presentation
      宮崎
    • Year and Date
      2015-11-12
    • Related Report
      2015 Research-status Report
  • [Presentation] Neuroserpinの虚血時の脳細胞における神経保護作用2015

    • Author(s)
      浅川哲也, 杉山憲嗣, 野崎孝雄, 小林奨, 王亮, 張揚, 楊雪蓮, 鈴木勝昭, 難波宏樹
    • Organizer
      第16回日本分子庁外科学会
    • Place of Presentation
      浜松
    • Year and Date
      2015-08-28
    • Related Report
      2015 Research-status Report
  • [Book] Neural Functions of the Delta-Opioid Receptor2015

    • Author(s)
      Asakawa T, Xia Y*
    • Publisher
      Springer
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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