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Experimental research for the surgical target in Parkinson's disease

Research Project

Project/Area Number 15K10360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionDoshisha University (2018)
Dokkyo Medical University (2016-2017)
Kyoto University (2015)

Principal Investigator

Matsuda Wakoto  同志社大学, 研究開発推進機構, 嘱託研究員 (80444446)

Co-Investigator(Kenkyū-buntansha) 藤山 文乃  同志社大学, 脳科学研究科, 教授 (20244022)
薗村 貴弘  朝日大学, 歯学部, 准教授 (40347092)
高野 晋吾  筑波大学, 医学医療系, 教授 (50292553)
本間 智  金沢医科大学, 医学部, 教授 (40285581)
Project Period (FY) 2015-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsパーキンソン病 / 大脳基底核 / ウイルスベクター / 臨床解剖 / ドーパミン / 脳血管 / Heubner反回動脈 / 静脈洞交会 / 腹側被蓋野 / 大脳皮質 / 脳動脈 / ウィリス動脈輪 / 黒質 / 線条体 / 大脳基底核回路 / 淡蒼球外節 / 視床下核
Outline of Final Research Achievements

Dopaminergic neurons in the midbrain mediate a variety of brain functions, such as motor control, emotion, and reward. We studied the axonal arborization of ventral tegmental area (VTA) neurons with Sindbis virus vectors that coded membrane-targeted green fluorescent protein (GFP). After the reconstruction of projection axons, some neurons in VTA were observed to project their axons to the limbic cortices. The other neurons sent axons to the olfactory tubercle, accumbens nucleus, and/or caudate-putamen. Many of these neurons were observed to form relatively high-dense bushes in their terminal fields with ambiguous varicosities. Detail morphological images of neurons derived from this new approach are used to elucidate the role of the neurons in the basal ganglia. These results would also contribute to understanding the clinicopathology of Parkinson’s disease and related syndromes.

Academic Significance and Societal Importance of the Research Achievements

中脳ドーパミン系は、パーキンソン病、統合失調症などの疾患あるいは報酬行動・強化学習などに関与するとされる広域投射型モノアミン神経系の一つである。この新規手法によって見出された詳細な細胞形態は大脳基底核における神経細胞の役割を明らかにするとともに、パーキンソン病と関連疾患の臨床病理への理解を深めることに貢献するものと考えられる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (4 results)

  • [Journal Article] Anatomical variations of the torcular Herophili: macroscopic study and clinical aspects2018

    • Author(s)
      Matsuda Wakoto、Sonomura Takahiro、Honma Satoru、Ohno Sachi、Goto Tetsuya、Hirai Shuichi、Itoh Masahiro、Honda Yoshiko、Fujieda Hiroki、Udagawa Jun、Takano Shingo、Fujiyama Fumino、Ueda Shuichi
    • Journal Title

      Anatomical Science International

      Volume: in press Issue: 4 Pages: 464-468

    • DOI

      10.1007/s12565-018-0436-z

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pseudotumor cerebri and lung cancer-associated jugular vein thrombosis: Role of anatomical variations of torcular herophili.2018

    • Author(s)
      Matsuda W, Noguchi S, Fujiyama F
    • Journal Title

      eNeurologicalSci

      Volume: 13 Pages: 18-20

    • DOI

      10.1016/j.ensci.2018.11.002

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anatomical variations of the recurrent artery of Heubner: number, origin, and course2017

    • Author(s)
      Wakoto Matsuda, Takahiro Sonomura, Satoru Honma, Sachi Ohno, Tetsuya Goto, Shuichi Hirai, Masahiro Itoh, Yoshiko Honda, Hiroki Fujieda, Jun Udagawa, Shuichi Ueda
    • Journal Title

      Anatomical Science International

      Volume: 93(3) Issue: 3 Pages: 317-322

    • DOI

      10.1007/s12565-017-0415-9

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 神経科学と身心変容2017

    • Author(s)
      松田和郎
    • Journal Title

      身心変容技法研究

      Volume: 6 Pages: 166-169

    • Related Report
      2016 Research-status Report
  • [Journal Article] 脳幹の血管分布2017

    • Author(s)
      松田和郎
    • Journal Title

      Clinical Neuroscience

      Volume: 35

    • Related Report
      2016 Research-status Report
  • [Journal Article] 産業保健における脳血管障害.2016

    • Author(s)
      松田和郎、小泉明夫
    • Journal Title

      産業医学ジャーナル

      Volume: 39 Pages: 74-79

    • Related Report
      2015 Research-status Report
  • [Journal Article] A single-neuron tracing study of arkypallidal and prototypic neurons in healthy rats2015

    • Author(s)
      Fujiyama F, Nakano T, Matsuda W, Furuta T, Udagawa J, Kaneko T
    • Journal Title

      Brain Struct. Funct.

      Volume: published online Issue: 9 Pages: 1-8

    • DOI

      10.1007/s00429-015-1152-2

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 解剖実習脳における前大脳動脈の臨床解剖学的検討2017

    • Author(s)
      松田和郎、薗村貴弘、大野幸、平井宗一、本多祥子、本間智、伊藤正裕、宇田川潤、上田秀一
    • Organizer
      第122回日本解剖学会
    • Place of Presentation
      長崎県長崎市 長崎大学坂本キャンパス
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] 解剖実習脳における脳動脈瘤の出現頻度.2016

    • Author(s)
      松田和郎、薗村貴弘、大野幸、平井宗一、伊藤正裕、本多祥子、本間智、宇田川潤
    • Organizer
      第9回慶良間脳神経外科セミナー
    • Place of Presentation
      沖縄県島尻郡座間味村阿嘉 ペンションくば
    • Year and Date
      2016-10-13
    • Related Report
      2016 Research-status Report
  • [Presentation] 解剖実習脳における脳動脈瘤の出現頻度.2016

    • Author(s)
      松田和郎、薗村貴弘、大野幸、平井宗一、伊藤正裕、本多祥子、本間智、宇田川潤.
    • Organizer
      第121回日本解剖学会
    • Place of Presentation
      ビッグパレットふくしま (福島県郡山市)
    • Year and Date
      2016-03-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 特発性頭蓋内圧亢進症の1例:静脈洞交会の分岐様式から病態を考察する.2015

    • Author(s)
      松田和郎、薗村貴弘、平井宗一、本間智、植村正憲、伊藤正裕、宇田川潤.
    • Organizer
      第8回慶良間脳神経外科セミナー
    • Place of Presentation
      ペンションくば (沖縄県島尻郡座間味村)
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2020-03-30  

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