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Multil-modal analysis of pathological network in epilepsy: challenge targeted for MRI negative epilepsy

Research Project

Project/Area Number 15K10361
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionEhime University (2016-2017)
Kyoto University (2015)

Principal Investigator

Kunieda Takeharu  愛媛大学, 医学系研究科, 教授 (60609931)

Co-Investigator(Kenkyū-buntansha) 松本 理器  京都大学, 医学研究科, 准教授 (00378754)
澤本 伸克  京都大学, 医学研究科, 教授 (90397547)
菊池 隆幸  京都大学, 医学研究科, 助教 (40625084)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords難治性てんかん / ネットワーク / てんかん外科 / 脳磁図 / 空間フィルター法 / SEEG / MEG / てんかん原生領域 / FDG-PET
Outline of Final Research Achievements

Electrocorticography (ECoG) recorded with chronically implanted intracranial can visualize brain activity directly, leading to the identification of epileptogenic areas. Recently, it has been suggested that clinical condition of epilepsy forms pathologically complicated neural network. In this study, we successfully visualized the spatial and temporal organization of epileptogenecity by means of the spatial filter analysis of magnetoencephalogram (MEG), instead of the conventional analysis of equivalent electric current dipole (ECD) model. In addition to this, stereotactic EEG (SEEG) methods was installed as approved clinical research for the intractable epilepsy cases. In comparison with other non-invasive imaging modality, the clinical significance of this new spatial filter analysis in MEG was validated. Eventually, these results contributed to clarify the complicated pathological condition of intractable epilepsy.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (32 results)

All 2017 2016 2015

All Journal Article (17 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 17 results,  Open Access: 14 results,  Acknowledgement Compliant: 4 results) Presentation (13 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (2 results)

  • [Journal Article] Magnetoencephalography with temporal spread imaging to visualize propagation of epileptic activity2017

    • Author(s)
      Shibata S, Matsuhashi M, Kunieda T, Yamao Y, Rika Inano R, Kikuchi T, Imamura H, Takaya S, Matsumoto R, Ikeda A, Takahashi R, Mima T, Fukuyama H, Mikuni N, Miyamoto S
    • Journal Title

      Clin Neurophysiol

      Volume: 128 Issue: 5 Pages: 734-743

    • DOI

      10.1016/j.clinph.2017.01.010

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] We could predict good responders to vagus nerve stimulation: A surrogate marker by slow cortical potential shift2017

    • Author(s)
      Bayasgalan Borgil、Matsuhashi Masao、Fumuro Tomoyuki、Nohira Haruhiko、Nakano Naoki、Iida Koji、Katagiri Masaya、Shimotake Akihiro、Matsumoto Riki、Kikuchi Takayuki、Kunieda Takeharu、Kato Amami、Takahashi Ryosuke、Ikeda Akio
    • Journal Title

      Clinical Neurophysiology

      Volume: 128 Issue: 9 Pages: 1583-1589

    • DOI

      10.1016/j.clinph.2017.05.019

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High frequency activity overriding cortico-cortical evoked potentials reflects altered excitability in the human epileptic focus2017

    • Author(s)
      Kobayashi Katsuya、Matsumoto Riki、Matsuhashi Masao、Usami Kiyohide、Shimotake Akihiro、Kunieda Takeharu、Kikuchi Takayuki、Yoshida Kazumichi、Mikuni Nobuhiro、Miyamoto Susumu、Fukuyama Hidenao、Takahashi Ryosuke、Ikeda Akio
    • Journal Title

      Clinical Neurophysiology

      Volume: 128 Issue: 9 Pages: 1673-1681

    • DOI

      10.1016/j.clinph.2017.06.249

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single pulse electrical stimulation to probe functional and pathological connectivity in epilepsy2017

    • Author(s)
      Matsumoto R, Kunieda T, Nair D
    • Journal Title

      Seizure

      Volume: 44 Pages: 27-36

    • DOI

      10.1016/j.seizure.2016.11.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Frontal Fibers Connecting the Superior Frontal Gyrus to Broca Area: A Corticocortical Evoked Potential Study2017

    • Author(s)
      Ookawa Satoshi、Enatsu Rei、Kanno Aya、Ochi Satoko、Akiyama Yukinori、Kobayashi Tamaki、Yamao Yukihiro、Kikuchi Takayuki、Matsumoto Riki、Kunieda Takeharu、Mikuni Nobuhiro
    • Journal Title

      World Neurosurgery

      Volume: 107 Pages: 239-248

    • DOI

      10.1016/j.wneu.2017.07.166

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis, Clinical Indication, and Pending Problems in Surgical Treatment for Intractable Epilepsy2017

    • Author(s)
      國枝 武治、菊池 隆幸、吉田 和道、松本 理器、宮本 享
    • Journal Title

      Japanese Journal of Neurosurgery

      Volume: 26 Issue: 12 Pages: 856-863

    • DOI

      10.7887/jcns.26.856

    • NAID

      130006279253

    • ISSN
      0917-950X, 2187-3100
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCEPのオフライン解析と解釈2017

    • Author(s)
      小林勝哉,松本理器,松橋眞生,中江卓郎,宇佐美清英,山尾幸広,菊池隆幸,吉田和道,國枝武治,池田昭夫
    • Journal Title

      Japanese Journal of Clinical Neurophysiology

      Volume: 45 Issue: 2 Pages: 91-101

    • DOI

      10.11422/jscn.45.91

    • NAID

      130006351582

    • ISSN
      1345-7101, 2188-031X
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural pattern similarity between contra- and ipsilateral movements in high-frequency band of human electrocorticograms2017

    • Author(s)
      Fujiwara Y, Matsumoto R, Nakae T, Usami K, Matsuhashi M, Kikuchi T, Yoshida K, Kunieda T, Miyamoto S, Mima T, Ikeda A, Osu R
    • Journal Title

      Neuroimage

      Volume: 15 Pages: 302-313

    • DOI

      10.1016/j.neuroimage.2016.11.058

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical impact of intraoperative CCEP monitoring in evaluating the dorsal language white matter pathway2017

    • Author(s)
      Yamao Y, Suzuki K, Kunieda T, Matsumoto R, Arakawa Y, Nakae T, Nishida S, Inano R, Shibata S, Shimotake A, Kikuchi, T, Sawamoto N, Mikuni N, Ikeda A, Fukuyama H, Miyamoto S
    • Journal Title

      Human Brain Mapping

      Volume: 38 (4) Issue: 4 Pages: 1977-1991

    • DOI

      10.1002/hbm.23498

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The ‘when’and ‘where’of semantic coding in the anterior temporal lobe: temporal representational similarity analysis of electrocorticogram data2016

    • Author(s)
      Chen Y, Shimotake A, Matsumoto R, Kunieda T, Kikuchi T, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A, Lambon-Ralph MA
    • Journal Title

      Cortex

      Volume: 印刷中 Pages: 1-13

    • DOI

      10.1016/j.cortex.2016.02.015

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Visualization of heterogeneity and regional grading of gliomas by multiple features using magnetic resonance-based clustered images2016

    • Author(s)
      Inano R, Oishi N, Kunieda T, Arakawa Y, Kikuchi T, Fukuyama H, Miyamoto S.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 30344-30344

    • DOI

      10.1038/srep30344

    • NAID

      120005825907

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Network specific change in white matter integrity in mesial temporal lobe epilepsy.2016

    • Author(s)
      Imamura, H., R. Matsumoto, S. Takaya, T. Nakagawa, A. Shimotake, T. Kikuchi, N. Sawamoto, T. Kunieda, N. Mikuni, S. Miyamoto, H. Fukuyama, R. Takahashi and A. Ikeda
    • Journal Title

      Epilepsy Research

      Volume: 120 Pages: 65-72

    • DOI

      10.1016/j.eplepsyres.2015.12.003

    • NAID

      120005749848

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A possible variant of negative motor seizure arising from the supplementary negative motor area.2015

    • Author(s)
      Yamao Y, Matsumoto R, Kunieda K, Arakawa Y, Kikuchi T, Shibata S, Ikeda A, Fukuyama H, Miyamoto S
    • Journal Title

      Clin Neurol Neurosurg

      Volume: 134 Pages: 126-129

    • DOI

      10.1016/j.clineuro.2015.04.024

    • NAID

      120005749924

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reply to Commentary on "Neural correlates of mirth and laughter: a direct electrical cortical stimulation study"2015

    • Author(s)
      Yamao Y, Kunieda T, Matsumoto R
    • Journal Title

      Cortex

      Volume: 印刷中 Pages: 244-246

    • DOI

      10.1016/j.cortex.2015.03.019

    • NAID

      120005749925

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation.2015

    • Author(s)
      Usami K, Matsumoto R, Kobayashi K, Hitomi T, Shimotake A, Kikuchi T, Matsuhashi M, Kunieda T, Mikuni N, Miyamoto S, Fukuyama H, Takahashi R, Ikeda A.
    • Journal Title

      Hum Brain Mapp

      Volume: 36(11) Issue: 11 Pages: 4714-4729

    • DOI

      10.1002/hbm.22948

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Function of the nucleus accumbens in motor control during recovery after spinal cord injury.2015

    • Author(s)
      Sawada, M., K. Kato, T. Kunieda, N. Mikuni, S. Miyamoto, H. Onoe, T. Isa and Y. Nishimura
    • Journal Title

      Science

      Volume: 350 Issue: 6256 Pages: 98-101

    • DOI

      10.1126/science.aab3825

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] New Approach for Exploring Cerebral Functional Connectivity: Review of Cortico-cortical Evoked Potential2015

    • Author(s)
      Kunieda T, Yamao Y, Kikuchi T, Matsumoto R
    • Journal Title

      Neurologia medico-chirurgica

      Volume: 55 Issue: 5 Pages: 374-382

    • DOI

      10.2176/nmc.ra.2014-0388

    • NAID

      130005069876

    • ISSN
      0470-8105, 1349-8029
    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] てんかん外科における皮質ー皮質間誘発電位2017

    • Author(s)
      國枝武治
    • Organizer
      日本脳神経CI学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] てんかんの診断と外科治療の適応と課題2017

    • Author(s)
      國枝武治
    • Organizer
      日本脳神経外科コングレス
    • Related Report
      2017 Annual Research Report
  • [Presentation] 言語機能温存を目的とする覚醒科手術で画像記録システムの構築2017

    • Author(s)
      國枝武治
    • Organizer
      日本脳神経外科学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Preoperative evaluation of speech and memory dominance estimated by intracarotid propofol test.2017

    • Author(s)
      Takeharu Kunieda
    • Organizer
      Annual meeting of American Epilepsy Society
    • Related Report
      2017 Annual Research Report
  • [Presentation] てんかん外科における皮質―皮質間誘発電位2017

    • Author(s)
      國枝武治
    • Organizer
      日本脳神経CI学会
    • Place of Presentation
      鹿児島市
    • Related Report
      2016 Research-status Report
  • [Presentation] プロポフォールを用いた和田テストによる言語・記憶機能評価2016

    • Author(s)
      國枝武治
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      福岡市
    • Related Report
      2016 Research-status Report
  • [Presentation] SEEGによるてんかん焦点検索2016

    • Author(s)
      國枝武治
    • Organizer
      第46回臨床神経生理学会学術大会
    • Place of Presentation
      郡山市
    • Related Report
      2016 Research-status Report
  • [Presentation] プロポフォールを用いた和田テストによる言語・記憶評価2015

    • Author(s)
      國枝武治
    • Organizer
      日本てんかん学会
    • Place of Presentation
      長崎
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 焦点診断と硬膜下電極留置の適応2015

    • Author(s)
      國枝武治
    • Organizer
      日本てんかん学会
    • Place of Presentation
      長崎
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 皮質―皮質間誘発電位を用いた、言語機能の術中モニタリング2015

    • Author(s)
      國枝武治
    • Organizer
      日本脳神経外科学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2015-10-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 皮質―皮質間誘発電位を用いた言語機能の術中モニタリングと覚醒下手術2015

    • Author(s)
      國枝武治
    • Organizer
      ヒト脳機能マッピング学会
    • Place of Presentation
      大阪
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Intraoperative application of CCEP for exploring functional connectivity2015

    • Author(s)
      T. Kunieda
    • Organizer
      8th KST meeting
    • Place of Presentation
      ソウル
    • Year and Date
      2015-05-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] てんかん治療のための良性腫瘍治療2015

    • Author(s)
      國枝武治
    • Organizer
      日本脳神経外科コングレス
    • Place of Presentation
      横浜
    • Year and Date
      2015-05-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Book] 脳波判読の基礎と手術への応用「発作時脳波の測定方法と読み方」2016

    • Author(s)
      國枝武治、小林勝哉
    • Total Pages
      11
    • Publisher
      メジカルビュー社
    • Related Report
      2016 Research-status Report
  • [Book] 脳神経外科診療プラクティス7・グリオーマ治療のDecision Making・「2.グリオーマ摘出に必要な解剖組織と術中機能検査 C.言語野」2016

    • Author(s)
      國枝武治、山尾幸広
    • Total Pages
      5
    • Publisher
      文光堂
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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