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Effect of deep brain stimulation to autonomic dysfunction in patients with Parkinson's desease

Research Project

Project/Area Number 15K10368
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionInternational University of Health and Welfare (2018-2019)
Dokkyo Medical University (2015-2017)

Principal Investigator

Uchiyama Tomoyuki  国際医療福祉大学, 医学部, 教授 (70345015)

Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsパーキンソン病 / 脳深部刺激療法 / 自律神経障害 / 下部尿路機能障害 / 排便障害 / 睡眠障害 / 自律神経機能
Outline of Final Research Achievements

We have observed and analysed the changes of some autonomic functions and autonomic dysfunctions before and after the surgery of deep brain stimulation therapy to subtharamic nucleus (STN-DBS), because we evaluate the effect of STN-DBS for some autonomic functions and autonomic dysfunctions in patinets with Parkinson’s disease. And also we have done similar evaluation before and after the surgery of deep brain stimulation therapy to globus pallidus (Gpi-DBS). And to analyze the time-dependent change of the effect of both DBS therapy, we underwent the similar evaluation 3 mouths, 1 year and 3 years after the surgery. We have collected the many data about motor and non-motor symptom/sign before and after the surgery. Now we are analyzing about the effect of the surgery for some autonomic functions and autonomic dysfunctions. And we presented the some results of our study in neurological meeting and published it in neurological paper.

Academic Significance and Societal Importance of the Research Achievements

本研究は、従来DBSの自律神経系に対する影響と効果に関する検討は非常に少なく、また脳神経内科と脳神経外科のほか、自律神経系に関わる各科にわたる分野横断的な研究であるため、国内外において数少ない研究・試みである。現在、膨大なデータを解析中であるが、予想される結果・意義として、DBSの自律神経系への作用に関するデータ、自律神経系に関連する各種機能に対する安全性と有用性に関するデータ、自律神経系の変化によるQOLへの影響に関するデータなどを示すことができる。またDBSを受ける又は受けたPD患者およびDBSに携わる医療関係者に対して有益なデータを提供でき、PD診療に多大な貢献をなしうると考えている。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (6 results)

All 2020 2019

All Journal Article (3 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 3 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Decline in drawing ability and cerebral perfusion in Parkinson’s disease patients after subthalamic nucleus deep brain stimulation surgery2020

    • Author(s)
      Shogo Furukawa、Shigeki Hirano、Tatsuya Yamamoto、Masato Asahina、Tomoyuki Uchiyama、Yoshitaka Yamanaka、Yoshikazu Nakano、Ai Ishikawa、Kazuho Kojima、Midori Abe、Yuriko Uji、Yoshinori Higuchi、Takuro Horikoshi、Takashi Uno、Satoshi Kuwabara
    • Journal Title

      Parkinsonism and Related Disorders

      Volume: in press

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Determinants of Low Body Mass Index in Patients with Parkinson’s Disease: A Multicenter Case-Control Study2020

    • Author(s)
      Suzuki Keisuke、Okuma Yasuyuki、Uchiyama Tomoyuki、Miyamoto Masayuki、Haruyama Yasuo、Kobashi Gen、Sakakibara Ryuji、Shimo Yasushi、Hatano Taku、Hattori Nobutaka、Yamamoto Toshimasa、Hirano Shigeki、Yamamoto Tatsuya、Kuwabara Satoshi、Kaji Yoshiaki、Fujita Hiroaki、Kadowaki Taro、Hirata Koichi
    • Journal Title

      Journal of Parkinson's Disease

      Volume: 10 Issue: 1 Pages: 213-221

    • DOI

      10.3233/jpd-191741

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genitourinary manifestations of Parkinson’s disease2019

    • Author(s)
      Tomoyuki Uchiyama, Jalesh N Panicker
    • Journal Title

      BJUI Knowledge

      Volume: ePub

    • DOI

      10.18591/bjuik.0039

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Characteristics of lower gastrointestinal tract function in patients with Parkinson’s disease2019

    • Author(s)
      Uchiyama T, Yamamoto T, Sakakibara R, et al
    • Organizer
      23rd International Congress of Parkinson’s disease and Movement Disorders
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Book] パーキンソン病200年‐James Parkinsonの夢‐2020

    • Author(s)
      内山智之,榊原隆次,桑原聡,平田幸一
    • Total Pages
      16
    • Publisher
      中外医学社
    • ISBN
      9784498328464
    • Related Report
      2019 Annual Research Report
  • [Book] 神経内科 Clinical Question & Pearls パーキンソン病2019

    • Author(s)
      内山智之, 榊原隆次, 桑原 聡, 平田幸一
    • Total Pages
      7
    • Publisher
      中外医学社
    • ISBN
      9784498328044
    • Related Report
      2019 Annual Research Report

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Published: 2015-04-16   Modified: 2021-02-19  

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