Research for mechanism of speech acquisition using new generation diffusion MRI and functional MRI
| Project/Area Number |
15K10372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
浅野 恵子 順天堂大学, 医学部, 先任准教授 (40407234)
中島 円 順天堂大学, 医学部, 准教授 (50317450)
宮嶋 雅一 順天堂大学, 医学部, 先任准教授 (60200177)
新井 一 順天堂大学, 医学部, 教授 (70167229)
青木 茂樹 順天堂大学, 医学(系)研究科(研究院), 教授 (80222470)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脳可塑性 / 言語獲得 / 機能MRI / 拡散MRI / コネクトーム / 言語 / fMRI / DTI / default mode network / コネクトーム解析 / バイリンガル / 言語機能 / reorganization |
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| Outline of Final Research Achievements |
Cortical activation and fiber network alternation during speech acquisition were analyzed using functional MRI (fMRI) and diffusion MRI (dMRI). According to acquisition of second language, we classified the participants into the simultaneous bilinguals (0-6 years old) and the sequential bilinguals (7 years older) and compared to data of monolingual control. On fMRI during second language task, the sequential bilinguals showed broad activation on speech association area, but the simultaneous bilinguals had restricted activation. On connectome analysis using dMRI, the simultaneous bilinguals increase number of fibers (NOF) between right putamen to precentral gyrus, however the sequential bilinguals reduce NOF on speech association areas.
Early exposure of language could induce fiber network to obtain speech function. After paradigm change of language acquisition, broad cortical activation could be compensated for less fiber network.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Change of Amyloid-β 1-42 Toxic Conformer Ratio After Cerebrospinal Fluid Diversion Predicts Long-Term Cognitive Outcome in Patients with Idiopathic Normal Pressure Hydrocephalus2018
Author(s)
Akiba C, Nakajima M, Miyajima M, Ogino I, Motoi Y, Kawamura K, Adachi S, Kondo A, Sugano H, Tokuda T, Irie K, Arai H
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Journal Title
J Alzheimers Dis.
Volume: 25
Issue: 3
Pages: 989-1002
DOI
Related Report
Peer Reviewed / Open Access
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