The beta-band oscillatory activity of local field potentials and single neurons in patients with Parkinsons disease
| Project/Area Number |
15K10374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Takamitsu 日本大学, 医学部, 客員教授 (50158284)
FUKAYA Chikashi 日本大学, 医学部, 准教授 (50287637)
OSHIMA Hideki 日本大学, 医学部, 准教授 (20328735)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脳深部刺激療法 / パーキンソン病 / βオシレーション / 局所電場電位 / 微小電極 / オシレーション / 脳深部神経活動電位記録 / 視床下核 / 微小電極記録 |
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| Outline of Final Research Achievements |
This study aims to assess the beta-band oscillation activity from local field potentials (LFPs) measured with microelectrodes during surgery for the subthalamic nucleus (STN) deep brain stimulation (DBS) in patients with Parkinson’s disease (PD; 4 patients, six sides). We assessed the maximum value of the power of the oscillation at the beta-band (beta power) within STN. Thus, on 5 out of 6 sides, the dorsal side within STN exhibited the maximum beta power within STN, corroborating a previous study on LFPs recorded with macroelectrodes, such as DBS electrodes, that reported the beta-band oscillation elevation in the dorsal side in STN in PD.
We examined the beta power outside STN, revealing a high beta power on 5 out of 6 sides at the dorsal side outside STN (average, 2.8 mm from the dorsal boundary of STN). The beta power may reflect the activities of surrounding structures such as the thalamus.
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Report
(4 results)
Research Products
(7 results)
