| Project/Area Number |
15K10375
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
深谷 親 日本大学, 医学部, 准教授 (50287637)
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| Research Collaborator |
SEKIGUCHI Shinichi
MATSUDA Keiko
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脊髄刺激 / 脳卒中後疼痛 / 運動麻痺 / ケタミン / ドラッグチャレンジテスト / 脳卒中後運動麻痺 / 脊髄刺激療法 / ドラッグチャレンジ テスト |
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| Outline of Final Research Achievements |
We have applied 5 Hz cervical SCS which induce muscle twitches of extremities in combination with conventional 20 Hz cervical SCS to induce paresthesia over the painful area in poststroke pain patients. The patients received 5 Hz cervical SCS to induce muscle twitches for five minutes in one session, and five sessions per day were carried out. In addition, patients underwent 20 Hz cervical SCS to induce paresthesia as much as they required. The %VAS score reduction 24 months after chronic SCS and the results of the ketamine test showed a significant correlation (r = 0.670, p = 0.001) by Pearson’s correlation coefficient test. In patients treated with a combination of cervical 5 Hz and 20 Hz SCS, the motor function of the upper extremities recovered remarkably.The combination of 5 Hz and 20 Hz SCS is a new neuromodulation and neurorehabilitation technique for poststroke pain with motor weakness.
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