Analysis of mechanisms to develop hydrocephalus using mice model
| Project/Area Number |
15K10380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
Isogai Eriko 千葉県がんセンター(研究所), 発がん研究グループ 実験動物研究室, 上席研究員 (40300917)
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| Co-Investigator(Kenkyū-buntansha) |
若林 雄一 千葉県がんセンター(研究所), 発がん研究グループ 実験動物研究室, 室長 (40303119)
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| Co-Investigator(Renkei-kenkyūsha) |
OHIRA Miki 千葉県がんセンター研究所, がんゲノム研究室, 室長 (20311384)
HASEGAWA Yuzo 千葉県がんセンター研究所, 脳神経外科, 医師 (60436409)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 神経発生 / 水頭症 / モデル動物 |
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| Outline of Final Research Achievements |
100 % of double transgenic mice (Tg) of Lmo3 and Hen2 developed hydrocephalus. The cortex, ventricular and subventricular zone were thin and intermediate progenitor cells (IPC) were increased in cortex of embryo. Over-expression of both of Lmo3 and Hen2 by in utero electroporation increased IPC but not neuron and each of them decreased IPC and increased neuron. Therefore, over-expression of each gene might decrease IPC and deplete stem cells by premature neurogenesis. On the other hand, over-expression of both genes might deplete stem cells by induction of excess IPC. Both cases could lead to aberrant neuronal development and hydrocephalus.
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Report
(4 results)
Research Products
(31 results)
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[Presentation] A cancer modifier role for Parathyroid hormone in mouse skin carcinogenesis2015
Author(s)
Kazuhiro Okumura, Megumi Saito, Eriko Isogai, Ikuo Miura, Shigeharu Wakana, Midori Shimanuki, Hiroshi Shitara, Choji Taya, Ryo Kominami, Yuichi Wakabayashi
Organizer
29th International Mammalian Genome Conference
Place of Presentation
Yokohama Port Opening Memorial Hall, RIKEN Yokohama Campus
Year and Date
2015-11-08
Related Report
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