Anti-cytokine therapy for lumbar spinal disorder.

• Project/Area Number: 15K10385
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Chiba University
• Principal Investigator: Ohtori Seiji 千葉大学, 大学院医学研究院, 教授 (40361430)
• Co-Investigator(Kenkyū-buntansha): 高橋 和久 千葉大学, 大学院医学研究院, 教授 (20179477) ; 山内 かづ代 千葉大学, 大学院医学研究院, 特任講師 (30648069) ; 折田 純久 千葉大学, 大学院医学研究院, 助教 (60638310)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 腰痛 / サイトカイン / 疼痛 / 治療 / 腰椎疾患

Outline of Final Research Achievements

Inflammatory cytokines and aberrant innervation have attracted attention as therapeutic targets for discogenic low back pain (DLBP). Anti-tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) inhibitors are reportedly effective for DLBP. Studies have reported increased vascular endothelial growth factor (VEGF) levels, which increase inflammatory cytokines and aberrant innervation, in painful discs in animals and humans. Here, we prospectively investigated the efficacy of a VEGF inhibitor for DLBP. Low back pain at 2, 3 and 4 weeks post-administration significantly decreased after injection of VEGF inhibitor. Serum cytokine levels did not significantly change and no harmful side effects were observed after administration of VEGF. Anti-VEGF therapy is more effective at alleviating DLBP.

Research Products

• [Journal Article] Single intradiscal injection of the interleukin-6 receptor antibody (2016)
  • Author(s): Sainoh T, Orita S, Miyagi M, Inoue G, Yamauchi K, Suzuki M, Sakuma Y,
  • Journal Title: Journal of Orthopaedic Science Volume: 21(1) Issue: 1 Pages: 2-6
  • DOI: 10.1016/j.jos.2015.10.005
  • Peer Reviewed
• [Presentation] Modic type 1 change influences surgical outcome in selected patients with diskogenic low back pain. (2016)
  • Author(s): Ohtori S, Orita S, Yamauchi K, Eguchi Y, Aoki Y, SUzuki M, Kubota G, Inage K, Sainoh T, Sato J, Fujimoto K, Shiga Y, Abe K, Kanamoto H, Takahashi K.
  • Organizer: The 43th International Society for the Study of the Lumbar Spine
  • Place of Presentation: Marina Bay Sands Convention Center(Singapore)
  • Year and Date: 2016-05-16