| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
To identify the cell type that expressed p-p38 and p-ERK MAPK in spinal cord with chronic compression. Of 12 weeks old twy/twy mice, double stained cells for p-ERK and CD11b were rarely found. The cell markers showed that p-p38 MAPK-IR cells completely co-localized with CD11b, but not with either GFAP or NeuN at all-time points examined. The rate of MAPK-positive/ GFP-positive cells was higher as the degree of the compression of spinal cord. As a result of this research, we suggested that in the spinal cord with chronic compression the failure and hyperpermeability of BSCB could be occur according to compression degree and that hematogenous macrophage would be random migration in the spinal cord could be as one of the clinical condition of the neuropathic pain.
|
