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Pathological of neuropathic pain with chronic progressive spinal cord compression.

Research Project

Project/Area Number 15K10391
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionUniversity of Fukui

Principal Investigator

Takeura Naoto  福井大学, 学術研究院医学系部門, 特別研究員 (00615304)

Co-Investigator(Kenkyū-buntansha) 中嶋 秀明  福井大学, 学術研究院医学系部門, 講師 (10397276)
内田 研造  福井大学, 医学部, 教授 (60273009)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords脊髄慢性圧迫 / twyマウス / MAPK / マクロファージ / 頚椎症性脊髄症 / 脊髄障害性疼痛 / 脊髄血液関門 / 神経障害性疼痛 / 慢性圧迫脊髄
Outline of Final Research Achievements

To identify the cell type that expressed p-p38 and p-ERK MAPK in spinal cord with chronic compression. Of 12 weeks old twy/twy mice, double stained cells for p-ERK and CD11b were rarely found. The cell markers showed that p-p38 MAPK-IR cells completely co-localized with CD11b, but not with either GFAP or NeuN at all-time points examined. The rate of MAPK-positive/ GFP-positive cells was higher as the degree of the compression of spinal cord. As a result of this research, we suggested that in the spinal cord with chronic compression the failure and hyperpermeability of BSCB could be occur according to compression degree and that hematogenous macrophage would be random migration in the spinal cord could be as one of the clinical condition of the neuropathic pain.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2016 2015

All Presentation (7 results)

  • [Presentation] 慢性脊髄圧迫モデルにおける血管脊髄関門機能変化と脊髄障害性疼痛発現2016

    • Author(s)
      竹浦直人, 中嶋秀明, 髙橋藍, 本定和也, 内田研造
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 圧迫性頚髄症モデル(twyマウス)を用いた脊髄障害性疼痛に関する基礎的研究2016

    • Author(s)
      竹浦直人, 中嶋秀明, 高橋藍, 本定和也, 北出誠, 小久保安朗
    • Organizer
      第126回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2016-04-08
    • Related Report
      2015 Research-status Report
  • [Presentation] 慢性圧迫脊髄におけるMRI髄内輝度変化と血液脊髄関門の透過性変化2016

    • Author(s)
      竹浦直人
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 慢性脊髄圧迫モデルにおける血管脊髄関門機能変化と脊髄障害性疼痛発現2016

    • Author(s)
      竹浦直人
    • Organizer
      第89回日本整形外科学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 圧迫性頚髄症モデル(twyマウス)を用いた脊髄障害性疼痛に関する基礎的研究2016

    • Author(s)
      竹浦直人
    • Organizer
      第126回中部日本整形外科災害外科学会・学術集会
    • Place of Presentation
      アクトシティ浜松(静岡県浜松市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 圧迫性頚髄症に伴う慢性疼痛における血液脊髄関門を介したmacrophageの動態2015

    • Author(s)
      竹浦直人, 中嶋秀明, 高橋藍, 渡邉修司, 本定和也, 北出誠, 杉田大輔, 内田研造
    • Organizer
      第8回日本運動器疼痛学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 慢性脊髄圧迫に伴う疼痛にblood‐spinal cord barrierの破綻が関与している2015

    • Author(s)
      竹浦直人, 中嶋秀明, 吉田藍, 本定和也, 内田研造
    • Organizer
      第30回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山国際会議場ほか
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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