| Project/Area Number |
15K10394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
二村 圭祐 大阪大学, 医学系研究科, 准教授 (00462713)
林 正徳 信州大学, 学術研究院医学系, 助教 (20624703)
加藤 博之 信州大学, 学術研究院医学系, 教授 (40204490)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 狭窄性腱鞘炎 / エストロゲン / エストロゲン受容体 / 閉経 / エストロゲンレセプター / 滑膜内腱 / Saa / 閉経モデルマウス / 腱鞘炎 / 腱細胞 / 腱鞘滑膜 |
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| Outline of Final Research Achievements |
Stenosing tenosynovitis is often diagnosed in postmenopausal women or perinatal women. However, little is known about the pathogenic mechanism of tenosynovitis. We attempted to clarify the relationship between estrogen and pathogenesis of tenosynovitis using ovariectomized (OVT) mice. Real-time PCR analysis of OVT mice demonstrated an increased expression of estrogen receptor alpha (ERα) in the intrasynovial tendon. RNA-sequence analysis detected 30 genes that showed more than twice the expression of ERαcompared to the OVT group, and included SAA1 and SAA3 genes as acute inflammatory markers. Our results suggest that estrogen plays an important role in maintaining the homeostasis of intrasynovial tendons, and a failure of the homeostasis caused by the lack of estrogen may lead to the development of tenosynovitis.
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