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Pharmacologic Approaches to Preserve the Neuromuscular Junction after Traumatic Nerve Injury

Research Project

Project/Area Number 15K10401
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionNagoya University

Principal Investigator

Kurimoto Shigeru  名古屋大学, 医学系研究科, 特任講師 (70597856)

Co-Investigator(Kenkyū-buntansha) 石井 久雄  名古屋大学, 医学系研究科, 寄附講座助教 (30738349)
西塚 隆伸  名古屋大学, 医学部, 招聘教員 (20725535)
平田 仁  名古屋大学, 予防早期医療創成センター(医), 教授 (80173243)
山本 美知郎  名古屋大学, 医学系研究科, 特任講師 (90528829)
岩月 克之  名古屋大学, 医学部附属病院, 講師 (90635567)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords神経筋接合部 / 末梢神経 / 脱神経筋 / Wnt / 末梢神経損傷 / 神経再生 / アセチルコリン受容体 / 運動終板
Outline of Final Research Achievements

In the rat sciatic nerve transection model, not only the Wnt/beta-catenin pathway but also the non-canonical pathway of Wnt signaling, such as Wnt4, Wnt9a, Wnt11, were activated secondary to traumatic nerve injury. The effect of the Wnt antagonists on acetylcholine receptor (AChR) cluster formation were also investigated. The treatment of C2C12 myotubes by IWR1 and porc inhibitor increased the number of AChR clusters. Wnt signaling pathway may be a useful therapeutic target to prevent the motor endplate degeneration that occurs following traumatic nerve injury with Wnt inhibitors serving as a pharmacologic adjunct to surgical repair.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (18 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] ES細胞を用いた運動機能再建 (シンポジウム 再生医療の最先端)2016

    • Author(s)
      平田 仁
    • Journal Title

      日本整形外科学会雑誌

      Volume: 90 Pages: 13-17

    • NAID

      40020728933

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 末梢神経損傷治療の課題と将来展望2018

    • Author(s)
      栗本秀
    • Organizer
      第29回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reconstruction of Motor Function in Peripheral Nerves by Transplantation of human iPSC-derived Motor Neuron Progenitors2018

    • Author(s)
      Satoshi Niwa, Masaomi Saeki, Hiroki Shinkai, Shigeru Kurimoto, Tomonori Nakano, Yohei Okada, Hitoshi Hirata
    • Organizer
      2017 Annual Meeting of the Orthopaedic Research society
    • Related Report
      2017 Annual Research Report
  • [Presentation] 神経筋接合部の制御2018

    • Author(s)
      栗本秀
    • Organizer
      第33回日本整形外科学会基礎学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reconstruction of Denervated Muscles Using Motor Neurons Derived from Mouse ES Cells2017

    • Author(s)
      Hiroki Shinkai, Satoshi Niwa, Shigeru Kurimoto, Yohei Okada, Hitoshi Hirata
    • Organizer
      Annual Meeting of Orthopaedic Research Society
    • Place of Presentation
      San Diego(U.S.A)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 神経筋接合部の再形成を促進するための薬理学的アプローチ2017

    • Author(s)
      能登公俊、栗本秀、石井久雄、大西哲朗、岩月克之、平田仁
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ES細胞由来運動神経細胞移植による末梢神経の運動機能再建2017

    • Author(s)
      新海宏明、丹羽智史、栗本秀、岡田洋平、平田仁
    • Organizer
      第60回日本手外科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 末梢神経における胎児由来神経前駆細胞移植による感覚神経再生2017

    • Author(s)
      浅野研一、中野智則、丹羽智史、新海宏明、栗本秀、平田仁
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ES細胞由来運動神経細胞移植による末梢神経の運動機能再建2017

    • Author(s)
      新海宏明、丹羽智史、中野智則、栗本秀、岡田洋平、平田仁
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 末梢神経へのヒトiPS細胞由来の運動神経前駆細胞移植による運動機能の再構築2017

    • Author(s)
      丹羽智史、新海宏明、中野智則、栗本秀、小野寺一成、岡田洋平、平田仁
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 末梢神経における胎児由来神経前駆細胞移植による感覚神経再生2017

    • Author(s)
      浅野研一、中野智則、佐伯将臣、丹羽智史、新海宏明、栗本秀、平田仁
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒトiPS細胞由来運動神経前駆細胞を用いた末梢神経における運動機能再建2017

    • Author(s)
      丹羽智史、佐伯将臣、新海宏明、中野智則、栗本秀、岡田洋平、平田仁
    • Organizer
      第28回日本末梢神経学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ES細胞由来運動神経細胞移植による末梢神経の運動機能再建2017

    • Author(s)
      新海宏明、丹羽智史、佐伯将臣、中野智則、栗本秀、岡田洋平、平田仁
    • Organizer
      第32回日本整形外科学会基礎学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Reconstruction of motor function in peripheral nerves by transplantation of hiPSC-derived motor neuron progenitors2017

    • Author(s)
      Satoshi Niwa, Hiroki Shinkai, Kazunari Onodera, Takuji Ito, Satoshi Tanaka, Jiawei Li, Shigeru Kurimoto, Tomonori Nakano, Manabu Doyu, Hitoshi Hirata, Yohei Okada
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ヒト iPS 細胞由来の運動神経細胞移植による末梢神経における運動機能再建2017

    • Author(s)
      丹羽智史、新海宏明、中野智則、栗本秀、小野寺一成、岡田洋平、平田仁
    • Organizer
      第60回日本手外科学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Transplanted Neurons in Peripheral Nerve Provide a Novel Treatment Strategy for Paralyzed Muscles.2016

    • Author(s)
      Shigeru Kurimoto, Tomonori Nakano, Hiroaki Shinkai, Satoshi Nina, Masahiro Tatebe, Hitoshi Hirata
    • Organizer
      71th Annual Meeting of the ASSH
    • Place of Presentation
      Austin(U.S.A)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Creation of ectopic neural ganglion within peripheral nerve graft2016

    • Author(s)
      Tomonori Nakano, Shigeru Kurimoto, Kennichi Asano, Hiroki Shinnkai, Satoshi Niwa, Hitoshi Hirata
    • Organizer
      71th Annual Meeting of the ASSH
    • Place of Presentation
      Austin(U.S.A)
    • Year and Date
      2016-09-29
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脱神経筋の変性に影響を与えるWntシグナル およびその伝達経路の解明2016

    • Author(s)
      栗本 秀, 能登 公俊, 赤根 真央, 中川 泰伸, 米田 英正, 中野 智則, 西塚 隆伸, 岩月 克之, Ranjan Gupta, 平田 仁
    • Organizer
      第27回日本末梢神経学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-08-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Screening of a novel drug to activate the formation of neuromuscular junctions2015

    • Author(s)
      Hisao Ishii, Shigeru Kurimoto, Tomonori Nakano, Michiro Yamamoto, Katsuyuki Iwatsuki, Hitoshi Hirata
    • Organizer
      70th Annual Meeting of the American Society for Surgery of the Hand
    • Place of Presentation
      Seattle, USA
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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