| Project/Area Number |
15K10404
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
Otsuki Bungo 京都大学, 医学研究科, 助教 (30646766)
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| Co-Investigator(Kenkyū-buntansha) |
藤林 俊介 京都大学, 医学研究科, 特定教授 (30362502)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Seiji 中部大学, 生命健康科学部, 講師 (50726198)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | PEEK / 表面処理 / 酸化チタン / コーティング / 酸化チタンコーティング / 椎体間ケージ / ビーグル犬 / 頚椎前方固定 / チタンコーティング |
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| Outline of Final Research Achievements |
We have developed novel TiO2 coating technology on PEEK surface without changing the material properties of PEEK and verified its usefulness in vivo and in vitro study. Implants prepared using TiO2 blasting as a pretreatment and TiO2 coating by the Sol - gel method have superior surface structures for precipitation of hydroxyapatite in simulated body fluids and promotion of bone marrow stem cells into osteogenic differentiation. In animal experiments using rabbits, the material showed better binding ability with bone tissue than that of control group, and the mechanical tensile test had a stronger tensile strength compared with the control group. We also clarified the superiority of the material using anterior cervical fusion model of beagle dogs with higher union rate than that of control material.
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