| Project/Area Number |
15K10405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
岡田 潔 大阪大学, 医学(系)研究科(研究院), 助教 (40576279)
岡 久仁洋 大阪大学, キャンパスライフ健康支援センター, 助教 (50724085)
村瀬 剛 大阪大学, 医学系研究科, 准教授 (50335361)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | シュワン細胞 / ミトコンドリア / 神経因性疼痛 |
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| Outline of Final Research Achievements |
We found that methylcobalamin, which is used as a therapeutic agent for peripheral neuropathy, is one of candidate substances to regulate mitochondrial function in Schwann cells. Methylcobalamin increases the NAD+/NADH value, which is an indicator of mitochondrial function in Schwann cells, inhibits dedifferentiation and promotes differentiation/myelination of Schwann cells in vitro. Methylcobalamin also inhibits demyelination of peripheral nerve in vivo. It was suggested that methylcobalamin could be a novel treatment for neuropathic pain by regulating the mitochondrial function in Schwann cells.
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