Regenerative transplantation therapy by using large animal spinal cord injury model

• Project/Area Number: 15K10411
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kagoshima University
• Principal Investigator: ABEMATSU Masahiko 鹿児島大学, 医歯学域附属病院, 助教 (70448190)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 脊髄損傷 / 大型動物

Outline of Final Research Achievements

We developed a new cure to show high curative effect for spinal cord injury by using valproic acid with histone deacetylase inhibitory activity together with neural stem cell transplant so far. However, clinical by this new cure that we developed this time safely; it is necessary for the primate who is near to Homo sapiens to examine curative effect in detail to apply it.
Because we developed the study using the rat, mouse spinal cord injury model so far, I applied the technique and developed spinal cord injury model manufacture device for exclusive use of the Macaca fascicularis. Spinal cord injury by three severe different damage energy slight medium degree, and after evaluating a hind leg function, graded functional disorder was seen according to size of the damage energy afterwards.

Research Products

• [Journal Article] Distribution of ossified spinal lesions in patients with severe ossification of the posterior longitudinal ligament and prediction of ossification at each segment based on the cervical OP index classification: a multicenter study (JOSL CT study). (2018)
  • Author(s): Hirai T, Yoshii T, Nagoshi N, Takeuchi K, Mori K, Ushio S, Abematsu M, Haro H, Ohba T, Watanabe M, Katoh H, Watanabe K, Ozawa H, Kanno H, Imagama S, Ando K, Fujibayashi S, Koda M, Yamazaki M, Matsumoto M, Nakamura M, Okawa A, Kawaguchi Y.
  • Journal Title: BMC Musculoskelet Disord. Volume: 19(1) Issue: 1 Pages: 107-107
  • DOI: 10.1186/s12891-018-2009-7
  • NAID: 120007133040
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypertrophic spinal pachymeningitis associated with human T-cell lymphotrophic virus-1 infection and Sjogren's syndrome: A case report and brief literature review. (2018)
  • Author(s): Bureta CA, Abematsu M, Tominaga H, Saitoh Y, Kawamura I, Nagano S, Setoguchi T, Ishidou Y, Yamamoto T, Komiya S.
  • Journal Title: Int J Surg Case Rep. Volume: 45 Pages: 22-28
  • DOI: 10.1016/j.ijscr.2018.03.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Lumbar spine epidural abscess and facet joint septic arthritis due to Streptococcus agalactiae: a case report. (2018)
  • Author(s): Bureta C, Tominaga H, Yamamoto T, Setoguchi T, Kawamura H, Nagano S, Kawamura I, Abematsu M, Kakoi H, Ishidou Y, Komiya S.
  • Journal Title: BMC Surg. Volume: 18(1) Issue: 1 Pages: 16-16
  • DOI: 10.1186/s12893-018-0350-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prior Treatment with Anti-High Mobility Group Box-1 Antibody Boosts Human Neural Stem Cell Transplantation-Mediated Functional Recovery After Spinal Cord Injury. (2018)
  • Author(s): Uezono N, Zhu Y, Y, Matsuda T,Nakajo M, Abematsu M, Setoguchi T, Mori S, Takahashi HK, Komiya S, Nishibori M, Nakashima K:
  • Journal Title: Stem Cells Volume: - Issue: 5 Pages: 0-0
  • DOI: 10.1002/stem.2802
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevalence and distribution of ossification of the supra/interspinous ligaments in symptomatic patients with cervical ossification of the posterior longitudinal ligament of the spine: a CT-based multicenter cross-sectional study. (2016)
  • Author(s): Mori K, Yoshii T, Hirai T, Abematsu M, et. al
  • Journal Title: BMC Musculoskelet Disord. Volume: 17(1) Pages: 492-492
  • NAID: 120007134948
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevalence and Distribution of Ossified Lesions in the Whole Spine of Patients with Cervical Ossification of the Posterior Longitudinal Ligament A Multicenter Study (JOSL CT study). (2016)
  • Author(s): Hirai T, Yoshii T, Iwanami A, Takeuchi K, Mori K, Yamada T, Wada K, Koda M, Matsuyama Y, Takeshita K, Abematsu M, Haro H, Watanabe M, Watanabe K, Ozawa H, Kanno H, Imagama S, Fujibayashi S, Yamazaki M, Matsumoto M, Nakamura M, Okawa A, Kawaguchi Y.
  • Journal Title: PLoS One. Volume: 11(8) Issue: 8 Pages: e0160117-e0160117
  • DOI: 10.1371/journal.pone.0160117
  • NAID: 120005997756
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Retro-odontoid mass without atlantoaxial instability causing cervical myelopathy: a case report of transdural surgical resection. (2016)
  • Author(s): Tominaga H, Setoguchi T, Nagano S, Kawamura I, Abematsu M, Yamamoto T, Ishidou Y, Matsuyama K, Ijiri K, Tanabe F, Komiya S.
  • Journal Title: Spinal Cord Ser Cases. Volume: 2 Issue: 1 Pages: 16025-16025
  • DOI: 10.1038/scsandc.2016.25
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Risk factors for unavoidable removal of instrumentation after surgical site infection of spine surgery: A retrospective case-control study. (2016)
  • Author(s): Tominaga H, Setoguchi T, Kawamura H, Kawamura I, Nagano S, Abematsu M, Tanabe F, Ishidou Y, Yamamoto T, Komiya S.
  • Journal Title: Medicine (Baltimore) Volume: 95(43)
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Reduced Adult Hippocampal Neurogenesis and Cognitive Impairments following Prenatal Treatment of the Antiepileptic Drug Valproic Acid (2015)
  • Author(s): Juliandi B, Tanemura K, Igarashi K, Tominaga T, Furukawa Y, Otsuka M, Moriyama N, Ikegami D, Abematsu M, Sanosaka T, Tsujimura K, Narita M, Kanno J, Nakashima K
  • Journal Title: Stem Cell Rep Volume: 5 Issue: 6 Pages: 996-1009
  • DOI: 10.1016/j.stemcr.2015.10.012
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 特発性脊髄ヘルニアに対する手術療法と術後成績 (2017)
  • Author(s): 棈松昌彦、冨永博之、山元拓哉、米和徳、井尻幸成、小宮節郎
  • Organizer: 第１３３回西日本整形・災害外科学会学術集会
• [Presentation] ビデオセッション 顕微鏡下脊髄手術 (2016)
  • Author(s): 棈松昌彦、冨永博之、山元 拓哉、米 和徳、小宮 節郎
  • Organizer: 第１３２回 西日本整形・災害外科学会学術集会
  • Place of Presentation: 鹿児島県民交流センター（鹿児島県鹿児島市）
  • Year and Date: 2016-11-19
  • Invited
• [Presentation] 脊椎髄膜腫における２７年間の術後成績と治療における工夫 (2016)
  • Author(s): 棈松 昌彦、河村 一郎、山元 拓哉、米 和徳、小宮 節郎
  • Organizer: 第４５回 日本脊椎脊髄病学会
  • Place of Presentation: 幕張メッセ（千葉県千葉市美浜区）
  • Year and Date: 2016-04-14
• [Presentation] 胸椎後縦靭帯骨化症に対する後方除圧固定術後の治療成績 (2016)
  • Author(s): 棈松昌彦、冨永博之、山元 拓哉、米 和徳、小宮 節郎
  • Organizer: OPLL班会議
  • Place of Presentation: 東京医科歯科大学（東京都文京区）
• [Presentation] Reconstruction of injured spinal cord by epigenetic regulation of transplanted neural stem cells (2015)
  • Author(s): Masahiko Abematsu
  • Organizer: The 4th International Conference and Exhibition on Pathology
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2015-07-13
  • Int'l Joint Research