Sarcopenia in degenerative spinal disease
| Project/Area Number |
15K10425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
SAKAI Yoshihito 国立研究開発法人国立長寿医療研究センター, 整形外科部, 部長 (70378107)
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| Co-Investigator(Kenkyū-buntansha) |
原田 敦 国立研究開発法人国立長寿医療研究センター, 病院, 病院長 (80198910)
佐竹 昭介 国立研究開発法人国立長寿医療研究センター, 老年学・社会科学研究センター フレイル研究部, フレイル予防医学研究室長 (50508116)
伊藤 研悠 名古屋大学, 医学部附属病院, 医員 (10732638)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | サルコペニア / 脊椎脊髄病学 / 脊椎変性 / 老化 / 脊椎変性疾患 / フレイル |
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| Outline of Final Research Achievements |
We investigated the prevalence of sarcopenia and the influences on treatment outcomes in the elderly patients with spinal representative disease such as cervical spondylotic myelopathy (CSM) and lumbar spinal stenosis (LSS). Sarcopenia was evaluated using whole-body dual-energy x-ray absorptiometry (DXA) before and after surgical treatment. The prevalence of sarcopenia was 28.1% in CSM and 25.1% in LSS, respectively. Cross-sectional evaluation of muscle mass was associated with the treatment of spinal disease, thus sarcopenia seems to be a valuable investigative tool for elderly locomotive disorders and therapeutic approach targeted to skeletal muscle should be promising to improve surgical outcomes. Longitudinal evaluation of muscle mass, namely, actual aging change in skeletal muscle mass may be open up a new possibilities for the definition of sarcopenia, because longitudinal decline in muscle mass was associated with the surgical results in patients with LSS either.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Rapid Worsening of Symptoms and High Cell Proliferative Activity in Intra- and Extramedullary Spinal Hemangioblastoma: A Need for Earlier Surgery.2017
Author(s)
Shiro Imagama, Zenya Ito, Kei Ando, Kazuyoshi Kobayashi, Tetsuro Hida, Kenyu Ito, Yoshimoto Ishikawa, Mikito Tsushima, Akiyuki Matsumoto, Hiroaki Nakashima, Norimitsu Wakao, Yoshihito Sakai, Yukihiro Matsuyama, Naoki Ishiguro.
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Journal Title
Global Spine J.
Volume: 7
Issue: 1
Pages: 6-13
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Posterior Surgery for Adolescent Idiopathic Scoliosis with Pedicle Screws and Ultra-high Molecular Weight Polyethylene Tape: Achieving the Ideal Thoracic Kyphosis.2016
Author(s)
Imagama S, Ito Z, Wakao N, Ando K, Hirano K, Tauchi R, Muramoto A, Matsui H, Matsumoto T, Ishiguro N, Sakai Y, Katayama Y, Matsuyama Y
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Journal Title
Clin Spine Surg.
Volume: 29
Issue: 8
Pages: 376-383
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Appropriate timing of surgical intervention for the proximal type of cervical spondylotic amyotrophy.2015
Author(s)
Tauchi R, Imagama S, Inoh H, Yukawa Y, Kanemura T, Sato K, Matsubara Y, Harada A, Sakai Y, Hachiya Y, Kamiya M, Yoshihara H, Ito Z, Ando K, Hirano K, Muramoto A, Matsui H, Matsumoto T, Ukai J, Kobayashi K, Shinjo R, Nakashima H, Ishiguro N.
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Journal Title
Eur J Orthop Surg Traumatol
Volume: 25
Issue: S1
Pages: 107-113
DOI
Related Report
Peer Reviewed
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[Journal Article] Proteomic analysis of ligamentum flavum from patients with lumbar spinal stenosis.2014
Author(s)
Kamita M, Mori T, Sakai Y, Ito S, Gomi M, Miyamoto Y, Harada A, Niida S, Yamada T, Watanabe K, Ono M.
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Journal Title
Proteomics
Volume: 15
Issue: 9
Pages: 1622-1630
DOI
Related Report
Peer Reviewed
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[Presentation] サルコペニアの評価法2016
Author(s)
原田敦 松井康素 酒井義人 竹村真理枝
Organizer
第89回日本整形外科学会学術総会
Place of Presentation
横浜
Year and Date
2016-05-12
Related Report
Invited
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