Effects of total hip arthroplasty stem composed of Ti-Nb-Sn alloy with low Young's modulus on the improvement of stress shielding

• Project/Area Number: 15K10428
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tohoku University
• Principal Investigator: Mori Yu 東北大学, 大学病院, 助教 (70634541)
• Co-Investigator(Kenkyū-buntansha): 花田 修治 東北大学, 金属材料研究所, 名誉教授 (10005960) ; 正橋 直哉 東北大学, 金属材料研究所, 教授 (20312639) ; 森 菜緒子 東北大学, 大学病院, 助教 (90535064)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 低弾性チタン合金 / 人工関節

Outline of Final Research Achievements

Total hip arthroplasty stems of Ti6Al4V alloy and TiNbSn alloy were produced with the same design. It is confirmed that the Young’s modulus of the TiNbSn alloy stem is 55 GPa. The modulus of elasticity of the Ti6Al4V alloy stem was 110 GPa. Total hip arthroplasties were performed on 10 kg male Beagle dogs. We plan to observe the bone formation around the stem by the CT image and evaluate histological analyses of bone tissue around the stems at 1 year after surgery. We compare the results of stress analyses using FEM with CT images and histological findings. We also assessed the effects of anodizing treatment of TiNbSn alloy on improvement of bone compatibility and of the low elasticity on bone union acceleration. In the rabbit tibia model and the mouse tibia model, improved bone synthesis in the fracture site was indicated in TiNbSn group compared with the stainless steel group or the Ti6Al4V group.

Research Products

• [Journal Article] Effects of intramedullary nails composed of a new β-type Ti-Nb-Sn alloy with low Young's modulus on fracture healing in mouse tibiae (2018)
  • Author(s): Fujisawa Hirokazu、Mori Yu、Kogure Atsushi、Tanaka Hidetatsu、Kamimura Masayuki、Masahashi Naoya、Hanada Shuji、Itoi Eiji
  • Journal Title: J Biomed Mat Res B Appl Biomater Volume: - Issue: 8 Pages: 2841-2848
  • DOI: 10.1002/jbm.b.34064
  • Peer Reviewed
• [Journal Article] Study of bioactivity on a TiNbSn alloy surface (2017)
  • Author(s): N. Masahashi , Y.Mori, H. Tanaka, A. Kogure, H. Inoue, K. Ohmura, Y. Kodama, M. Nishijima, E. Itoi, S. Hanada
  • Journal Title: Thin Solid Films Volume: 639 Pages: 22-28
  • DOI: 10.1016/j.tsf.2017.08.023
  • Peer Reviewed
• [Journal Article] Apatite Formation and Biocompatibility of a Low Young's Modulus Ti-Nb-Sn Alloy Treated with Anodic Oxidation and Hot Water. (2016)
  • Author(s): Tanaka H, Mori Y, Noro A, Kogure A, Kamimura M, Yamada N, Hanada S, Masahashi N, Itoi E
  • Journal Title: PLoS One Volume: Feb 25; 11(2) Issue: 2 Pages: e0150081-e0150081
  • DOI: 10.1371/journal.pone.0150081
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 表面改質を施したインプラント用TiNbSn合金の生体活性 (2016)
  • Author(s): 正橋直哉、森 優、田中秀達、小暮敦史、野呂篤司、上村雅之、山田則一、井樋栄二、花田修治
  • Journal Title: チタン Volume: 64(3) Pages: 50-5
  • NAID: 40020919675
  • Acknowledgement Compliant
• [Presentation] Effects of Elastic Intramedullary Nails of Low Young's Modulus Ti-Nb-Sn-alloy on Bone Healing (2017)
  • Author(s): Atsushi Kogure, Yu Mori, Hidetatsu Tanaka, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Eiji Itoi
  • Organizer: Orthopedic research society annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2017-03-19
  • Int'l Joint Research
• [Presentation] The effects of elastic intramedullary nails of low Young’s modulus new β type Ti-Nb-Sn alloy on fracture healing in mice (2017)
  • Author(s): Hirokazu Fujisawa, Yu Mori, Masayuki Kamimura, Shuji Hanada, Eiji Itoi
  • Organizer: Orthopedic research society annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2017-03-19
  • Int'l Joint Research
• [Presentation] Interface Analysis of the low Young’s Modulus Ti-Nb-Sn Alloy with Anodic Oxidation and Hot Water Treatment Implanted to Rabbit Femur (2017)
  • Author(s): Tanaka H, Mori Y, Kogure A ,Hanada S, Masahashi N, Itoi E
  • Organizer: Orthopedic research society annual meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2017-03-19
  • Int'l Joint Research
• [Presentation] The effects of elastic intramedullary nails of low Young's modulus new β type Ti-Nb-Sn alloy on fracture healing in mice. (2017)
  • Author(s): H Fujisawa, Y Mori, M Kamimura, S Hanada, E Itoi
  • Organizer: ORS 2017
  • Int'l Joint Research
• [Presentation] Interface Analysis of the low Young’s Modulus Ti-Nb-Sn Alloy with Anodic Oxidation and Hot Water Treatment implanted to rabbit femur (2017)
  • Author(s): Hidetatsu Tanaka, Yu Mori, Atsushi Kogure, Shuji Hanada, Naoya Masahashi, Eiji Itoi
  • Organizer: ORS 2017
  • Int'l Joint Research
• [Presentation] Biomechanical Analysis of Supra-Acetabular Insufficiency Fracture (2017)
  • Author(s): Hidetatsu Tanaka, Go Yamako, Hiroaki Kurishima, Shutaro Yamashita, Yu Mori, Daisuke Chiba, Etsuo Chosa, Eiji Itoi
  • Organizer: ORS 2017
  • Int'l Joint Research
• [Presentation] Effects of Elastic Intramedullary Nails of Low Young's Modulus Ti-Nb-Sn-alloy on Bone Healing (2017)
  • Author(s): "Atsushi Kogure, Yu Mori, Hidetatsu Tanaka, Masayuki Kamimura, Naoya Masahashi, Shuji Hanada, Eiji Itoi"
  • Organizer: ORS 2017
  • Int'l Joint Research
• [Presentation] Fracture fixation with an intramedullary nail of low Young’s modulus Ti-Nb-Sn alloy enhances fracture healing. (2016)
  • Author(s): 5.Kogure A, Mori Y, Tanaka H, Hanada S, Itoi E.
  • Organizer: 3rd AOTrauma Asia Pacific Scientific Congress
  • Place of Presentation: Chengdu, China
  • Year and Date: 2016-05-27
  • Int'l Joint Research
• [Presentation] Apatite Formation and Biocompatibility of a Low Young’s Modulus Ti-Nb-Sn Alloy Treated with Anodic Oxidation and Hot Water (2016)
  • Author(s): Hidetatsu Tanaka , Yu Mori , Atsushi Noro , Atsushi Kogure , Masayuki Kamimura , Norikazu Yamada , Shuji Hanada , Naoya Masahashi , Eiji Itoi
  • Organizer: Orthopaedic Research Society 2016 Annual Meeting
  • Place of Presentation: Orlando, Florida, USA
  • Year and Date: 2016-03-05
  • Int'l Joint Research
• [Presentation] 陽極酸化と温水処理を施行した低弾性β型Ti-Nb-Sn合金の骨親和性の検討 (2015)
  • Author(s): 田中秀達 森優 野呂篤司 小暮敦史 山田則一 正橋直哉 花田修治 井樋栄二
  • Organizer: 第31回日本整形外科学会基礎学術集会
  • Place of Presentation: 富山市
  • Year and Date: 2015-10-22
• [Presentation] 陽極酸化と温水処理を施行した低弾性β型Ti-Nb-Sn合金の骨親和性の検討 (2015)
  • Author(s): 田中秀達 森優 野呂篤司 小暮敦史 山田則一 正橋直哉 花田修治 井樋栄二
  • Organizer: 第33日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2015-07-23