Intra-operative imaging of soft tissue sarcoma with photoacoustic imaging

• Project/Area Number: 15K10429
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Tohoku University
• Principal Investigator: Watanuki Munenori 東北大学, 大学病院, 講師 (90451575)
• Co-Investigator(Kenkyū-buntansha): 西條 芳文 東北大学, 医工学研究科, 教授 (00292277) ; 萩原 嘉廣 東北大学, 医学系研究科, 准教授 (90436139)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 軟部肉腫 / 光音響顕微鏡 / 光音響効果 / ヌードマウス / 担癌マウス / IR780 / イメージング装置 / MG63 / 肉腫モデルマウス / 蛍光イメージング / 光音響顕微鏡装置 / 術中イメージング

Outline of Final Research Achievements

Surgery of soft tissue sarcoma is wide resection, which means macroscopically and microscopically complete sarcoma resection with reactive layer and normal tissue around it en bloc. Surgical margin is planned on the basis of pre-operative radiological findings. Under operation, it is quite difficult to confirm boundary between tumor and normal tissue and to judge whether tumor is properly resected. We could make photoacoustic imaging of human osteosarcoma xenograft in athymic nude mice. Photoacoustic imaging may enable intra-operative sarcoma imaging.