Analysis of mechanism of healing acceleration in soft tissue injuries under hyperbaric oxygen condition.
| Project/Area Number |
15K10433
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加藤 剛 東京医科歯科大学, 医学部附属病院, 助教 (80447490)
榎本 光裕 東京医科歯科大学, 医学部附属病院, 非常勤講師 (90451971)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 高気圧酸素 / 骨格筋 / 圧挫損傷 / 血管透過性 / 筋再生 / 筋衛星細胞 / 筋損傷 |
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| Outline of Final Research Achievements |
We assessed the effects of hyperbaric oxygen treatment (HBO) on contused calf muscles in a rat skeletal muscle injury model. An experimental HBO chamber was developed and rats were treated with 100% oxygen, 2.5 atmospheres absolute for 2h/day after injury. HBO reduced early lower limb volume and muscle wet weight in contused muscles, and promoted muscle isometric strength 7 days after injury. HBO suppressed the elevation of circulating macrophages in the acute phase and then accelerated macrophage invasion into the contused muscle. This environment also increased the number of proliferating and differentiating satellite cells and the amount of regenerated muscle fibers. Our results demonstrate that HBO has a dual role in decreasing inflammation and accelerating myogenesis in muscle contusion injuries.
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Report
(4 results)
Research Products
(52 results)
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[Presentation] 高気圧環境下における新型輸液ポンプの流量特性2016
Author(s)
後藤啓吾,大久保淳,山本素希,前田卓馬,宮本聡子,橋本由理恵,濱田真帆,倉島直樹,小栁津卓哉,榎本光裕,小島泰史,柳下和慶
Organizer
第51回日本高気圧環境・潜水医学会学術総会
Place of Presentation
日本医科大学（東京都文京区）
Year and Date
2016-12-03
Related Report
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[Presentation] 高気圧酸素治療の初回治療時における耳痛発生の検討2016
Author(s)
前田卓馬,大久保淳,山本素希,宮本聡子,橋本由理恵,濱田真帆,倉島直樹,小栁津卓哉,榎本光裕,小島泰史,柳下和慶
Organizer
第51回日本高気圧環境・潜水医学会学術総会
Place of Presentation
日本医科大学（東京都文京区）
Year and Date
2016-12-03
Related Report
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[Presentation] スポーツ外傷に対する高気圧酸素治療の根拠と実際 高気圧酸素治療のエビデンスと現状に基づき、将来像を探る 国立スポーツ科学センター(JISS)における高気圧酸素療法の実際2016
Author(s)
中嶋 耕平, 千葉 義夫, 半谷 美夏, 福田 直子, 藤木 崇史, 水谷 有里, 柳下 和慶, 武田 秀樹, 増島 篤, 奥脇 透, 川原 貴
Organizer
第27回日本臨床スポーツ医学会学術集会
Place of Presentation
幕張メッセ（千葉県千葉市）
Related Report
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