Elucidation of proliferation and metastasis mechanism of platelet-dependent bone soft tissue sarcoma and development of novel therapeutic method
| Project/Area Number |
15K10436
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
ICHIKAWA Jiro 山梨大学, 大学院総合研究部, 助教 (00456469)
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| Co-Investigator(Renkei-kenkyūsha) |
INOUE Katsue 山梨大学, 総合研究部, 教授 (10324211)
HARO Hirotaka 山梨大学, 総合研究部, 教授 (10313264)
ANDO Takashi 山梨大学, 総合研究部, 講師 (10377492)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 骨肉腫 / CLEC-2 / 血小板 / ポドプラニン / ＣＬＥＣ－２ |
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| Outline of Final Research Achievements |
TThe purpose of this study is to elucidate the role of the interaction of osteosarcoma podoplanin and both platelet CLEC-2 interaction in proliferation / metastasis and lead it to therapy. (1)Platelet Aggregation induced by osteosarcoma was confirmed. This aggregation was suppressed with podoplanin antibody and CLEC-2 blocking peptide. (2) Supernatant obtained by coculture with platelet and osteosarcoma induced osteosarcoma migration and EMT partially. (3) Lung metastasis was significantly suppressed when platelet CLEC-2 antibody was administered.
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Report
(4 results)
Research Products
(1 results)
