Development of novel treatment strategy against bone and soft tissue sarcoma by combination of tumor-specific oncolytic adenovirus and radiotherapy
Project/Area Number |
15K10446
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Okayama University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
藤原 俊義 岡山大学, 医歯薬学総合研究科, 教授 (00304303)
尾崎 敏文 岡山大学, 医歯薬学総合研究科, 教授 (40294459)
國定 俊之 岡山大学, 医歯薬学総合研究科, 准教授 (80346428)
藤原 智洋 岡山大学, 医歯薬学総合研究科, 助教 (80639211)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 腫瘍融解アデノウイルス / 骨・軟部肉腫 / 放射線治療 / 併用療法 |
Outline of Final Research Achievements |
Despite major advances in the treatment of bone and soft tissue sarcoma, those patients often show the refractory to conventional treatment, leading to poor prognosis. Therefore, the enhancement of sensitivity to radiotherapy is needed to improve the clinical outcome of bone and soft tissue sarcoma patients. We recently revealed that a tumor-specific, replication-competent oncolytic adenovirus Telomelysin (OBP-301) kills human sarcoma cells. In this study, we investigated the combination effect of Telomelysin and radiotherapy against human bone and soft tissue sarcoma cells. Combination with Telomelysin and radiotherapy showed more profound antitumor effect compared to monotherapy in vitro and in vivo. These results suggest that combination with Telomelysin and radiotherapy provides a novel therapeutic strategy for bone and soft tissue sarcoma.
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Report
(4 results)
Research Products
(14 results)
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[Presentation] Telomerase-specific Oncolytic Adenoviral Therapy Reverses Resistance to Chemotherapy and Radiotherapy in Human Osteosarcoma2017
Author(s)
Yusuke Mochizuki, Tomohiro Fujiwara, Toshinori Omori, Shuhei Osaki, Joe Hasei, Kazuhisa Sugiu, Tadashi Komatsubara,Tsuyoshi Sasaki, Toshiyuki Kunisada, Hitoshi Tazawa, Yasuo Urata, Shunsuke Kagawa, Toshiyoshi Fujiwara, Toshifumi Ozaki
Organizer
Orthopaedic Research Society 2017 Annual Meeting
Place of Presentation
San Diego, California, USA
Year and Date
2017-03-19
Related Report
Int'l Joint Research
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[Presentation] Molecular radiosensitization in soft tissue sarcomas by telomerase-specific oncolytic adenovirus2017
Author(s)
Tadashi Komatsubara, Toshinori Omori, Hiroshi Tazawa, Kazuhisa Sugiu, Yusuke Mochizuki, Yasuaki Yamakawa,Syuhei Osaki, Joe Hasei, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara
Organizer
American Association for CancerResearch 2017 Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] TELOMERASE-SPECIFIC ONCOLYTIC ADENOVIRUS ENHANCES RADIATION-INDUCED APOPTOSIS IN SOFT TISSUE SARCOMA CELLS BY ABLATING ANTI-APOPTIC MCL1 EXPRESSION2017
Author(s)
Tadashi Komatsubara, Hiroshi Tazawa, Yusuke Mochizuki, Kazuhisa Sugiu, Toshinori Omori, Yasuaki Yamakawa,Syuhei Osaki, Joe Hasei, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshiyoshi Fujiwara, Toshifumi Ozaki
Organizer
Connective Tissue Oncology Society Annual Meeting 2017
Related Report
Int'l Joint Research
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[Presentation] Radiosensitization of telomerase-targeted oncolytic adenovirus against human soft-tissue sarcoma2016
Author(s)
Tadashi Komatsubara, Toshinori Omori, Hiroshi Tazawa, Kazuhisa Sugiu, Yusuke Mochizuki, Yasuaki Yamakawa,Syuhei Osaki, Joe Hasei, Kouji Uotani, Tomohiro Fujiwara, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara
Organizer
第75回日本癌学会学術総会
Place of Presentation
パシフィコ横浜
Year and Date
2016-10-06
Related Report
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[Presentation] A novel treatment strategy for bone and soft tissue sarcomas with combination therapy of tumor-specfic oncolytic adenovirus and radiation2016
Author(s)
Toshinori Omori, Yasuaki Yamakawa, Joe Hasei, Hiroshi Tazawa, Tomohiro Fujiwara, Tadashi Komatsubara, Shuhei Osaki, Tsuyoshi Sasaki, Kazuhisa Sugiu, Aki Yoshida Toshiyuki Kunisada, Toshifumi Ozaki, Toshiyoshi Fujiwara
Organizer
Orthopaedic Research Society 2016 Annual Meeting
Place of Presentation
Orland, Florida
Year and Date
2016-03-05
Related Report
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[Presentation] 骨・軟部肉腫に対する腫瘍融解アデノウイルスと放射線療法の併用効果2015
Author(s)
大森 敏規, 山川 泰明, 長谷井 嬢,田澤 大, 尾崎 修平, 杉生 和久, 藤原 智洋, 国定 俊之, 浦田 泰生,藤原 俊義, 尾﨑 敏文
Organizer
第30回日本整形外科学会基礎学術集会
Place of Presentation
富山
Year and Date
2015-10-22
Related Report
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[Presentation] Radiosensitization of bone and soft tissue sarcoma cells by tumor-specific oncolytic adenovirus2015
Author(s)
Toshinori Omori, Yasuaki Yamakawa, Joe Hasei, Hiroshi Tazawa, Shuhei Osaki, Tsuyoshi Sasaki, Kazuhisa Sugiu, Tomohiro Fujiwara, Toshiyuki Kunisada, Toshifumi Ozaki, Toshiyoshi Fujiwara
Organizer
第74回日本癌学会学術総会
Place of Presentation
名古屋
Year and Date
2015-10-08
Related Report
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[Presentation] 骨・軟部肉腫に対する腫瘍融解アデノウイルスと放射線療法の併用効果2015
Author(s)
大森 敏規, 山川 泰明, 長谷井 嬢,田澤 大, 尾崎 修平, 杉生 和久, 藤原 智洋, 国定 俊之, 浦田 泰生,藤原 俊義, 尾﨑 敏文
Organizer
第48回日本整形外科学会 骨・軟部腫瘍学術集会
Place of Presentation
高松
Year and Date
2015-07-09
Related Report
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[Presentation] 骨・軟部肉腫に対する腫瘍融解アデノウイルスと放射線療法の併用効果2015
Author(s)
大森 敏規, 山川 泰明, 長谷井 嬢,田澤 大, 尾崎 修平, 杉生 和久, 藤原 智洋, 国定 俊之, 浦田 泰生,藤原 俊義, 尾﨑 敏文
Organizer
第88回日本整形外科学会学術総会
Place of Presentation
神戸
Year and Date
2015-05-21
Related Report