Roles of DNA repair imbalance in chromosomal translocation in sarcomas
| Project/Area Number |
15K10451
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
織田 信弥 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 腫瘍遺伝学研究室長 (40333372)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肉腫 / 染色体転座 / 融合遺伝子 / DNA二本鎖切断修復 |
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| Outline of Final Research Achievements |
Disease specific chromosomal translocation and the resulting fusion gene are essential for the oncogenesis of sarcomas. Abnormality of DNA double strand break repair (DSBR) system, including HR and NHEJ, play important roles in formation of chromosomal translocation. The expression of the factors involved in DSBR was explored by DNA microarray analysis in sarcoma cells with disease-specific chromosomal translocations. Focus assays were also carried out to examine the expression and subcellular localization of DSBR proteins. The results indicated that the enhancement of the expression of some DSBR factors and activation of the certain DSBR pathways in sarcoma cells.
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Report
(4 results)
Research Products
(12 results)
