| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Disease specific chromosomal translocation and the resulting fusion gene are essential for the oncogenesis of sarcomas. Abnormality of DNA double strand break repair (DSBR) system, including HR and NHEJ, play important roles in formation of chromosomal translocation. The expression of the factors involved in DSBR was explored by DNA microarray analysis in sarcoma cells with disease-specific chromosomal translocations. Focus assays were also carried out to examine the expression and subcellular localization of DSBR proteins. The results indicated that the enhancement of the expression of some DSBR factors and activation of the certain DSBR pathways in sarcoma cells.
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