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Roles of DNA repair imbalance in chromosomal translocation in sarcomas

Research Project

Project/Area Number 15K10451
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionOita University

Principal Investigator

TANAKA KAZUHIRO  大分大学, 医学部, 准教授 (10274458)

Co-Investigator(Kenkyū-buntansha) 織田 信弥  独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他部局等, 腫瘍遺伝学研究室長 (40333372)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肉腫 / 染色体転座 / 融合遺伝子 / DNA二本鎖切断修復
Outline of Final Research Achievements

Disease specific chromosomal translocation and the resulting fusion gene are essential for the oncogenesis of sarcomas. Abnormality of DNA double strand break repair (DSBR) system, including HR and NHEJ, play important roles in formation of chromosomal translocation. The expression of the factors involved in DSBR was explored by DNA microarray analysis in sarcoma cells with disease-specific chromosomal translocations. Focus assays were also carried out to examine the expression and subcellular localization of DSBR proteins. The results indicated that the enhancement of the expression of some DSBR factors and activation of the certain DSBR pathways in sarcoma cells.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

Research Products

(12 results)

All 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] MicroRNA-20b promotes cell proliferation via targeting of TGF-β receptor II and upregulates MYC expression in Ewing's sarcoma cells2018

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      Int J Oncol

      Volume: 51(6) Pages: 1842-1850

    • DOI

      10.3892/ijo.2017.4155

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] MicroRNA-181c prevents apoptosis by targeting of FAS receptor in Ewing’s sarcoma cells2018

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      Cancer Cell International

      Volume: 18 Pages: 1-11

    • DOI

      10.1186/s12935-018-0536-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors associated with the decision of operative procedure for proximal femoral bone metastasis: Questionnaire survey to institutions participating the Bone and Soft Tissue Tumor Study Group of the Japan Clinical Oncology Group2017

    • Author(s)
      Araki Nobuhito、Tanaka Kazuhiro、Katagiri Hirohisa、Kunisada Toshiyuki、Hiruma Toru、Hiraga Hiroaki、Morioka Hideo、Nishida Yoshihiro、Abe Satoshi、Watanuki Munenori、Morii Takeshi、Sugiura Hideshi、Yoshida Yukihiro、Yokoyama Koichiro、Shimose Shoji、Iwamoto Yukihide
    • Journal Title

      J Orthop Sci

      Volume: 22 Pages: 938-945

    • DOI

      10.1016/j.jos.2017.05.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor suppressive microRNA-138 inhibits metastatic potential via the targeting of focal adhesion kinase in Ewing’s sarcoma cells.2016

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Miyazaki M, Ikeda S, Tsumura H.
    • Journal Title

      Int J Oncol

      Volume: Mar;48(3): Pages: 1135-1144

    • DOI

      10.3892/ijo.2016.3317

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] MicroRNA-301a promotes cell proliferation via PTEN targeting in Ewing’s sarcoma cells2016

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H.
    • Journal Title

      Int J Oncol

      Volume: Apr;48(4): Pages: 1531-1540

    • DOI

      10.3892/ijo.2016.3379

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] microRNA-93 promotes cell proliferation via targeting of PTEN in Osteosarcoma cells.2015

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Ikeda S, Iwasaki T, Tsumura H
    • Journal Title

      Journal of Experimental & Clinical Cancer Research.

      Volume: 34 Pages: 76-76

    • DOI

      10.1186/s13046-015-0192-z

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] c-Myc Represses Tumor-Suppressive microRNAs, let-7a, miR-16 and miR-29b, and Induces Cyclin D2-Mediated Cell Proliferation in Ewing's Sarcoma Cell Line.2015

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0138560

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells.2015

    • Author(s)
      Kawano M, Tanaka K, Itonaga I, Iwasaki T, Miyazaki M, Ikeda S, Tsumura H
    • Journal Title

      International Journal of Oncology

      Volume: 34 Pages: 1543-1550

    • DOI

      10.3892/or.2015.4161

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] Sarcoma treatment and research in Japan.2018

    • Author(s)
      Tanaka K
    • Organizer
      Global Sarcoma Treatment and Research Symposium
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 軟部肉腫に対する化学療法と手術療法2017

    • Author(s)
      田仲和宏
    • Organizer
      第50回日本整形外科学会骨・軟部腫瘍学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 限局性肉腫の治療方針2017

    • Author(s)
      田仲和宏
    • Organizer
      第15回日本臨床腫瘍学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 骨肉腫に対する化学療法2017

    • Author(s)
      田仲和宏
    • Organizer
      第59回日本小児血液・がん学会学術集会
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-03-29  

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