comprehensive study for circadian clock and fracture
Project/Area Number |
15K10453
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
Fujiwara Hiroyashi 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (90381962)
|
Co-Investigator(Kenkyū-buntansha) |
小田 良 京都府立医科大学, 医学(系)研究科(研究院), 講師 (80516469)
|
Co-Investigator(Renkei-kenkyūsha) |
YAGITA KAZUHIRO 京都府立医科大学, 大学院医学研究科・統合生理学教室, 教授 (90324920)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 体内時計 / 骨折修復 / 概日リズム / 発光イメージング / 骨折モデル / 副甲状腺ホルモン / 発行イメージング / PTH / 温度補償性 / 骨折 / 創外固定器 |
Outline of Final Research Achievements |
Circadian clock exists all animal cells, contributes to regulate many physiological functions. We have already unveiled the existence of circadian clock in locomotorium system.But it was not clear how circadian clock function.Thus, we established fracture model and observed what was happened at healing site. Our experimental system prove that circadian clock have also work at fracture site.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Robust Circadian Rhythm and Parathyroid Hormone-Induced Resetting during Hypertrophic Differentiation in ATDC5 Chondroprogenitor Cells2015
Author(s)
Toshihiro Hosokawa, Yoshiki Tsuchiya, Naoki Okubo, Tatsuya Kunimoto, Yoichi Minami, Hiroyoshi Fujiwara, Yasuhiro Umemura, Nobuya Koike, Toshikazu Kubo, Kazuhiro Yagita
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Journal Title
ACTA HISTOCHEMICA ET CYTOCHEMICA
Volume: 48
Issue: 6
Pages: 165-171
DOI
NAID
ISSN
0044-5991, 1347-5800
Related Report
Peer Reviewed / Open Access
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[Presentation] Temperature is a time cue to cartilages2016
Author(s)
Naoki Okubo, Yoichi Minami, Hiroyoshi Fujiwara, Tatsuya Kunimoto, Toshihiro Hosokawa, Ryo Oda, Toshihiro Kubo, Kazuhiro Yagita
Organizer
62th Annual Meeting of Orthopaedic Research Society
Place of Presentation
Orland, United States
Year and Date
2016-03-06
Related Report
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