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Translational applications of broad spectrum natural compounds and phytochemicals or their derivatives to the novel treatment strategy against sarcomas

Research Project

Project/Area Number 15K10455
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionNara Medical University

Principal Investigator

Honoki Kanya  奈良県立医科大学, 医学部, 教授 (40336863)

Co-Investigator(Kenkyū-buntansha) 藤井 宏真  奈良県立医科大学, 医学部, 学内講師 (00625791)
辻内 俊文  近畿大学, 理工学部, 教授 (10254492)
藤間 保晶  奈良県立医科大学, 医学部, 研究員 (60448777)
Project Period (FY) 2015-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordssarcoma / metabolism / mitochondria / glycolysis / phytochemicals / c-myc / cancer stem cells / phytochmicals / mesenchymal stem cells / osteosarcoma / mitochondria metabolism / phytechemicals / pterostilbene / honokiol / c-myc inhibitor / Pterostilbene / Osteosarcoma / Colon cancer / Cancer stem cells / creatinine kinase / glucose metabolism / PI3k/Akt/mTOR / JAK/STAT
Outline of Final Research Achievements

Previous research has indicated that pterostilbene (PTE), one of the plant-derived polyphenols, suppressed the proliferative ability of osteosarcoma (OS) cell lines in a dose dependent manner, and the stem cell characteristics such as stem cell markers of Oct, CD44 and NS expression as well as sphere-forming ability. The current research revealed that the mechanism was found to be due to OXPHOS suppression and consequently reduction of ATP production by suppressing complex V activity as a result of an increase in ROS production in mitochondria. In addition, it was shown that tethering of mitochondria and endoplasmic reticulum via PDZD8 is involved in this process. Furthermore, PTE shows a synergistic effect with cMyc inhibitors such as honokiol, JQ1, OTX018, these results suggest that might be novel therapeutic agents against cancer stem cells in OS targeting mitochondrial metabolism.

Academic Significance and Societal Importance of the Research Achievements

骨肉腫患者の予後は、過去四半世紀にわたってブレークスルーがなく、患者の30%近くはいまだ非常に重度の予後、特に転移性疾患に直面している。したがって、新しい治療法が長い間渇望されてきた。本研究の結果は、c-Mycの関与するglycolysisおよびOXPHOSの特徴的な代謝フラックスの調節による「二重代謝阻害」が大きな相乗効果を示し、骨肉腫における幹細胞様細胞集団と一般的な腫瘍細胞集団の両方を標的とする新しい治療戦略となる可能性があることを示唆しており、この難治疾患治療に一筋の光明を与えるものである。

Report

(6 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (61 results)

All 2020 2019 2018 2017 2016 2015 Other

All Int'l Joint Research (2 results) Journal Article (32 results) (of which Int'l Joint Research: 17 results,  Peer Reviewed: 32 results,  Open Access: 16 results,  Acknowledgement Compliant: 4 results) Presentation (23 results) (of which Int'l Joint Research: 9 results,  Invited: 2 results) Book (4 results)

  • [Int'l Joint Research] Nova Scotia Community College/NGO Getting to Know Cancer(Canada)

    • Related Report
      2015 Research-status Report
  • [Int'l Joint Research]

    • Related Report
      2015 Research-status Report
  • [Journal Article] Similar local recurrence but better function with curettage versus resection for bone giant cell tumor and pathological fracture at presentation.2019

    • Author(s)
      Tsukamoto S, Mavrogenis AF, Tanzi P, Leone G, Righi A, Akahane M, Kido A, Honoki K, Tanaka Y,
    • Journal Title

      J Surg Oncol.

      Volume: 119 Issue: 7 Pages: 864-872

    • DOI

      10.1002/jso.25391

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Miscorrelation of Functional Outcome and Sociooccupational Status of Childhood, Adolescent, and Young Adult Generation With Bone and Soft Tissue Sarcoma Patients.2019

    • Author(s)
      Fujii H, Honoki K, Ishihara T, Shinomiya T, Tsukamoto S, Kido A, Kondoh Y, Kishi S, Shima M, Tanaka Y
    • Journal Title

      J Pediatr Hematol Oncol.

      Volume: 41 Issue: 2 Pages: 112-117

    • DOI

      10.1097/mph.0000000000001410

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Frequent mutations of genes encoding vacuolar H+ -ATPase components in granular cell tumors.2019

    • Author(s)
      Sekimizu M, Yoshida A, Mitani S, Asano N, Hirata M, Kubo T, Yamazaki F, Sakamoto H, Kato M, Makise N, Mori T, Yamazaki N, Sekine S, Oda I, Watanabe SI, Hiraga H, Yonemoto T, Kawamoto T, Naka N, Funauchi Y, Nishida Y, Honoki K, Kawano H, Tsuchiya H, Kunisada T, Matsuda K, Inagaki K, Kawai A, Ichikawa H.
    • Journal Title

      Genes Chromosomes Cancer

      Volume: 58 Issue: 6 Pages: 373-380

    • DOI

      10.1002/gcc.22727

    • Related Report
      2019 Annual Research Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Strategy of Dual Inhibition of Distinct Metabolic Features in Osteosarcoma2019

    • Author(s)
      Kishi Shingo、Honoki Kanya、Tanaka Yasuhito、Kuniyasu Hiroki
    • Journal Title

      Oteosarcoma. Diagnosis, Mechanisms, and Translational Developments

      Volume: - Pages: 81-96

    • DOI

      10.5772/intechopen.82612

    • ISBN
      9781839680144, 9781839680151
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells2018

    • Author(s)
      Takahashi K, Fukushima K, Tanaka K, Minami K, Ishimoto K, Otagaki S, Fukushima N, Honoki K, Tsujiuchi T
    • Journal Title

      Exp Cell Res.

      Volume: 369 Issue: 2 Pages: 316-324

    • DOI

      10.1016/j.yexcr.2018.05.037

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Effects of LPA1 and LPA6 on the regulation of colony formation activity in colon cancer cells treated with anticancer drugs2018

    • Author(s)
      Takahashi K, Fukushima K, Otagaki S, Ishimoto K, Minami K, Fukushima N, Honoki K, Tsujiuchi T.
    • Journal Title

      J Recept Signal Transduct Res.

      Volume: 38 Issue: 1 Pages: 71-75

    • DOI

      10.1080/10799893.2018.1426608

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of LPA receptor-5 in the enhancement of cell motile activity by phorbol ester and anticancer drug treatments in melanoma A375 cells2018

    • Author(s)
      Fukushima K, Takahashi K, Kurokawa A, Ishimoto K, Otagaki S, Minami K, Fukushima N, Honoki K, Tsujiuchi T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 496 Issue: 1 Pages: 225-230

    • DOI

      10.1016/j.bbrc.2018.01.030

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Introductory Chapter: From Chaos to Cosmos: Toward Precision Medicine in Osteosarcoma2017

    • Author(s)
      Honoki K, Weiss KR
    • Journal Title

      Osteosarcoma-Biology, Behavior and Mechanisms

      Volume: 1 Pages: 3-10

    • DOI

      10.5772/67265

    • ISBN
      9789535130956, 9789535130963
    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of high-grade osteosarcoma in a patient with recurrent giant cell tumor of the ischium while receiving treatment with denosumab.2017

    • Author(s)
      Tsukamoto S, Righi A, Vanel D, Honoki K, Donati DM, Errani C
    • Journal Title

      Jpn J Clin Oncol

      Volume: 47 Issue: 11 Pages: 1090-1096

    • DOI

      10.1093/jjco/hyx112

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Higher local recurrence rates after intralesional surgery for giant cell tumor of the proximal femur compared to other sites.2017

    • Author(s)
      Errani C, Tsukamoto S, Leone G, Akahane M, Cevolani L, Tanzi P, Kido A, Honoki K, Tanaka Y, Donati DM.
    • Journal Title

      Eur J Orthop Surg Traumatol.

      Volume: 27 Issue: 6 Pages: 813-819

    • DOI

      10.1007/s00590-017-1983-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Risk factors for local recurrence from atypical cartilaginous tumour and enchondroma of the long bones.2017

    • Author(s)
      Errani C, Tsukamoto S, Ciani G, Akahane M, Cevolani L, Tanzi P, Kido A, Honoki K, Tanaka Y, Donati DM.
    • Journal Title

      Eur J Orthop Surg Traumatol.

      Volume: 27 Issue: 6 Pages: 805-811

    • DOI

      10.1007/s00590-017-1970-4

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Enhanced cellular functions through induction of LPA2 by cisplatin in fibrosarcoma HT1080 cells2017

    • Author(s)
      Takahashi K, Fukushima K, Fukushima N, Honoki K, Tsujiuchi T
    • Journal Title

      Mol Cell Biochem

      Volume: 431 Issue: 1-2 Pages: 29-35

    • DOI

      10.1007/s11010-017-2971-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells.2017

    • Author(s)
      Fukushima K, Takahashi K, Yamasaki E, Onishi Y, Fukushima N, Honoki K, Tsujiuchi T
    • Journal Title

      Exp Cell Res

      Volume: 352 Issue: 1 Pages: 139-145

    • DOI

      10.1016/j.yexcr.2017.02.007

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Different effects of G-protein-coupled receptor 120 (GPR120) and GPR40 on cell motile activity of highly migratory osteosarcoma cells.2017

    • Author(s)
      Takahashi K, Fukushima K, Onishi Y, Node Y, Inui K, Fukushima N, Honoki K, Tsujiuchi T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 484 Issue: 3 Pages: 675-680

    • DOI

      10.1016/j.bbrc.2017.01.175

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells.2017

    • Author(s)
      Takahashi K, Fukushima K, Onishi Y, Inui K, Node Y, Fukushima N, Honoki K, Tsujiuchi T.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 483 Issue: 1 Pages: 652-657

    • DOI

      10.1016/j.bbrc.2016.12.088

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preventing aging with stem cell rejuvenation: Feasible or infeasible?2017

    • Author(s)
      Honoki K
    • Journal Title

      World J Stem Cells

      Volume: 9 Issue: 1 Pages: 1-8

    • DOI

      10.4252/wjsc.v9.i1.1

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells.2016

    • Author(s)
      Fukushima K, Takahashi K, Fukushima N, Honoki K, Tsujiuchi T.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 475 Issue: 1 Pages: 25-30

    • DOI

      10.1016/j.bbrc.2016.05.023

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] The clinical outcome of pazopanib treatment in Japanese patients with relapsed soft tissue sarcoma: A Japanese Musculoskeletal Oncology Group (JMOG) study.2016

    • Author(s)
      Nakamura T, Matsumine A, Kawai A, Araki N, Goto T, Yonemoto T, Sugiura H, Nishida Y, Hiraga H, Honoki K, Yasuda T, Boku S, Sudo A, Ueda T.
    • Journal Title

      Cancer

      Volume: 122(9) Issue: 9 Pages: 1408-1416

    • DOI

      10.1002/cncr.29961

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Negative effects of G-protein-coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells.2016

    • Author(s)
      Ishii S, Kitamura Y, Hirane M, Tomimatsu A, Fukushima K, Takahashi K, Fukushima N, Honoki K, Tsujiuchi T.
    • Journal Title

      Mol Carcinog

      Volume: 55 Issue: 11 Pages: 1553-1559

    • DOI

      10.1002/mc.22408

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crossroads of Hallmarks in Aging and Cancer: Anti-aging and anti-cancer target pathways can be shared?2016

    • Author(s)
      Honoki K, Fujii H, Tsukamoto S, Kishi S, Tsujiuchi T, Tanaka Y.
    • Journal Title

      Trends in Cancer Research

      Volume: 11 Pages: 39-59

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Designing a broad-spectrum integrative approach for cancer prevention and treatment.2015

    • Author(s)
      Block KI, ・・・ Honoki K, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl Pages: S276-S304

    • DOI

      10.1016/j.semcancer.2015.09.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A multi-targeted approach to suppress tumor-promoting inflammation.2015

    • Author(s)
      Samadi AK, ・・・Honoki K, ・・・Helferich WG, Yang X, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl Pages: S151-S184

    • DOI

      10.1016/j.semcancer.2015.03.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Broad targeting of resistance to apoptosis in cancer.2015

    • Author(s)
      Mohammad RM, ・・・ Honoki K, ・・・, Azmi AS, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl Pages: S78-S103

    • DOI

      10.1016/j.semcancer.2015.03.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.2015

    • Author(s)
      Feitelson MA,・・・Honoki K,・・・Nowsheen S, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomic instability in human cancer:Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.2015

    • Author(s)
      Ferguson LR, ・・・ Honoki K,・・・ Maxwell CA, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evasion of anti-growth signaling: a key step in tumorigenesis and potential target for treatment and prophylaxis by natural compounds.2015

    • Author(s)
      Amin AR, ・・・Honoki K, ・・・ Shin DM, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl Pages: S55-S77

    • DOI

      10.1016/j.semcancer.2015.02.005

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Therapeutic targeting of replicative immortality.2015

    • Author(s)
      Yaswen P, ・・・ Honoki K, Fujii H, ・・・ Yang X, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl Pages: S104-S128

    • DOI

      10.1016/j.semcancer.2015.03.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Cancer prevention and therapy through the modulation of the tumor microenvironment.2015

    • Author(s)
      Casey SC,・・・Honoki K,・・・Felsher DW, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl Pages: S199-S223

    • DOI

      10.1016/j.semcancer.2015.02.007

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tissue invasion and metastasis: Molecular, biological and clinical perspectives2015

    • Author(s)
      Jiang WG, ・・・ Honoki K, ・・・ Santini D, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl Pages: S244-S275

    • DOI

      10.1016/j.semcancer.2015.03.008

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] mmune evasion in cancer: Mechanistic basis and therapeutic strategies.2015

    • Author(s)
      Vinay DS, ・・・ Honoki K, ・・・ Kwon BS, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl Pages: S185-S198

    • DOI

      10.1016/j.semcancer.2015.03.004

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] biquilin 2 enhances osteosarcoma progression through resistance to hypoxic stress.2015

    • Author(s)
      Tsukamoto S, Shimada K, Honoki K, Kido A, Akahane M, Tanaka Y, Konishi N.
    • Journal Title

      Oncol Rep.

      Volume: 33 Pages: 1799-806

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Broad targeting of angiogenesis for cancer prevention and therapy.

    • Author(s)
      Wang Z,・・・ Honoki K, ・・・Jensen LD, et al.
    • Journal Title

      Semin Cancer Biol.

      Volume: Suppl Pages: S224-S243

    • DOI

      10.1016/j.semcancer.2015.01.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 進行期肉腫治療の現状と展望2020

    • Author(s)
      朴木寛弥
    • Organizer
      第10回埼玉骨軟部腫瘍研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] PterostilbeneはミトコンドリアのATP合成酵素阻害と活性酸素産生を介し骨肉腫細胞に対するcMYC阻害薬の効果を増強する2019

    • Author(s)
      岸 真五、朴木寛弥、ほか
    • Organizer
      第52回日本整形外科学会骨軟部腫瘍学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Endosialin抗体Ontuxizumabはfibronectin存在下における骨肉腫細胞の運動能を抑制する2019

    • Author(s)
      近藤裕美子、朴木寛弥、ほか
    • Organizer
      第52回日本整形外科学会骨軟部腫瘍学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 小児および思春期・若年成人(AYA)世代の肉腫患者における機能予後と社会心理的課題2019

    • Author(s)
      朴木寛弥、藤井宏真、ほか
    • Organizer
      第52回日本整形外科学会骨軟部腫瘍学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] DUAL INHIBITION OF DISTINCT METABOLIC FEATURES TARGETS OSTEOSARCOM STEM-LIKE CELLS BY PHYTOCHEMICAL PTEROSTILBENE AND C-MYC INHIBITORS2019

    • Author(s)
      Shingo Kishi, Kanya Honoki*, et al.
    • Organizer
      CTOS Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dual inhibition of distinct metabolic features targets osteosarcoma stem cells2019

    • Author(s)
      Shingo Kishi, Kanya Honoki, et al.
    • Organizer
      AACR 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ER-mitochondria tethering by PDZD8 regulates mitochondrial ATP-ROS balance in osteosarcoma cells2019

    • Author(s)
      Shingo Kishi, Shiori Mori, et al.
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Dual inhibition of distinct metabolic features targets osteosarcoma stem cells.2019

    • Author(s)
      Kishi S, Honoki K, Tsukamoto S, Hiromasa Fujii H, Kondoh Y, Tanaka Y, Kuniyasu H
    • Organizer
      AACR Annual Meeting 2019
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pterostilbene sensitizes osteosarcoma cells to killing by cMYC inhibitors2018

    • Author(s)
      KIshi S, Honoki K, Kuniyasu H, et al.
    • Organizer
      日本癌学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Mitochondria を標的とした肉腫治療の探索2018

    • Author(s)
      ShKishi S, Honoki K, Mori S, Kuniyasu H, Tanaka Y
    • Organizer
      第33回日本整形外科学会基礎学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ミトコンドリア代謝を標的とした肉腫治療の探索2018

    • Author(s)
      岸 真五、朴木寛弥、国安弘基 他
    • Organizer
      第51回日本整形外科学会骨軟部腫瘍学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Pterostilbene (3',5'-dimethoxyresveratrol) inhibits cell growth and augments the efficacy of doxorubicin through stem cell phenotype suppression in osteosarcoma cells in vitro2017

    • Author(s)
      Kishi S, Honoki K, Tsujiuchi T, Kuniyasu H, et al.
    • Organizer
      AACR Special Conference on Advances in Sarcomas: From Basic Science to Clinical Translation
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2017-05-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional outcome and socio-psychological problems for bone & soft tissue sarcoma patients in childhood & AYA generation2017

    • Author(s)
      Honoki K, et al
    • Organizer
      AACR Annual Meeting 2017
    • Place of Presentation
      Wshington, DC, USA
    • Year and Date
      2017-04-01
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pterostilbene (3',5'-dimethoxyresveratrol) inhibits cell growth and augments the efficacy of doxorubicin through stem cell phenotype suppression in osteosarcoma cells in vitro.2017

    • Author(s)
      Kishi, S, Honoki K, et al
    • Organizer
      AACR Special Conference on Advances in Sarcomas: From Basic Science to Clinical Translation
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Functional outcome and socio-psychological problems for bone & soft tissue sarcoma patients in childhood & AYA generation.2017

    • Author(s)
      Honoki K, et al.
    • Organizer
      AACR Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pterostilbene inhibits cell growth through suppression of stemness in osteosarcoma cell.2017

    • Author(s)
      Kishi S, Kuniyasu H, Honoki K, et al
    • Organizer
      76th Annual Meeting of JCA
    • Related Report
      2017 Research-status Report
  • [Presentation] 骨肉腫細胞に対する低グルコース環境下におけるクレアチニンキナーゼ阻害剤の抗腫瘍効果の検討2016

    • Author(s)
      岸 真五 朴木寛弥 国安弘基 他
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 小児・AYA世代骨軟部肉腫患者における身体的機能予後と社会的問題に ついて2016

    • Author(s)
      朴木寛弥、他
    • Organizer
      第49回日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 進行期軟部肉腫患者ケアにおける緩和的化学療法とpazopanibの意義2016

    • Author(s)
      朴木寛弥、他
    • Organizer
      第49回日本整形外科学会 骨・軟部腫瘍学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 進行期骨軟部悪性腫瘍患者の治療~緩和的化学療法・分子標的治療~2015

    • Author(s)
      朴木寛弥
    • Organizer
      KANSAI Sarcoma Conference
    • Place of Presentation
      大阪
    • Year and Date
      2015-11-13
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] OCIO-PHYSIOLOGICL PROBLEMS FOR BONE AND SOFT TISSUE SARCOMA PATIENTS IN CHILDHOOD AND AYA GENERATION2015

    • Author(s)
      Honoki K, Takeshita Y, Ishihara T, et al.
    • Organizer
      CTOS meeting
    • Place of Presentation
      Salt Lake City, USA
    • Year and Date
      2015-11-04
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 骨・軟部悪性腫瘍患者のtotal care management:緩和ケア, 地域連携 and beyond2015

    • Author(s)
      朴木寛弥・・・田中康仁 他
    • Organizer
      日本整形外科学会骨軟部腫瘍学会
    • Place of Presentation
      高松
    • Year and Date
      2015-07-09
    • Related Report
      2015 Research-status Report
  • [Presentation] Possible involvement of senescence bypass in mesenchymal stem cells for sarcomagenesis identified through a comparative gene expression profiling in rat sarcoma model2015

    • Author(s)
      Honoki K, Fujii H, Kido A, Tsukamoto S, Mori T, Tanaka Y, Tsujiuchi T
    • Organizer
      AACR annual meeting
    • Place of Presentation
      Philadelphia, USA
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Book] Oteosarcoma. Diagnosis, Mechanisms, and Translational Developments2019

    • Author(s)
      Cable MG, Randall RL
    • Total Pages
      118
    • Publisher
      InTech
    • ISBN
      9781839680144
    • Related Report
      2019 Annual Research Report
  • [Book] Osteosarcoma - Biology, Behavior and Mechanisms2019

    • Author(s)
      A Novel Strategy of Dual Inhibition of Distinct Metabolic Features in Osteosarcoma
    • Publisher
      Intech
    • ISBN
      9789535166634
    • Related Report
      2018 Research-status Report
  • [Book] Osteosarcoma: Biology, Behavior and Mechanisms.2017

    • Author(s)
      Kanya Honoki and Kurt Richard Weiss
    • Total Pages
      244
    • Publisher
      InTech
    • ISBN
      9789535130963
    • Related Report
      2017 Research-status Report
  • [Book] Osteosarcoma-Biology, Behavior and Mechanisms2017

    • Author(s)
      Honoki K, Weiss KR, ed.
    • Total Pages
      256
    • Publisher
      InTech
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2021-02-19  

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