| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
One of big problems is periprosthetic joint infection (PJI) in total joint arthroplasty. PJI cause a severe loosening of implant. Innate immunity and its effector mechanism with immune sensors, Toll-like receptor (TLR) and Nod-like receptor (NLR) at the forefront of host defense. We’ve reported the presenting of several TLRs and NLRs in macrophages of septic granuloma. We summarized TLRs and NLRs in septic THA. When TLRs recognized abnormal antigens, they stimulate production of proinflammatory cytokines and inflammasome.
Innate sensors including TLRs or NLRs were well-equipped in each subset of macrophage in septic loosening tissues around artificial hip joint in different manner depending on the pathologic conditions.
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