Development of a suspended synovium culture model mimicking inside of the knee joint
Project/Area Number |
15K10463
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
KATANO Hisako 東京医科歯科大学, 統合研究機構, 助教 (50376620)
|
Co-Investigator(Kenkyū-buntansha) |
関矢 一郎 東京医科歯科大学, 統合研究機構, 教授 (10345291)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 再生医療 / 再生医学 |
Outline of Final Research Achievements |
Drugs that induce mesenchymal stem cells (MSCs) from the synovium can be a promising treatment for mild tissue injury. We developed a suspended synovium culture model. Fibrous synovium was found to release greater numbers of MSCs than adipose synovium. Mobilization of MSCs from the synovium was demonstrated using a suspended synovium culture model in RA. This model can be a valuable tool to screen drugs which induce mobilization of MSCs from the synovium into synovial fluid in the knee joint.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] Harvested cell number varies greater in RA than in OA after a suspended synovium culture2017
Author(s)
Yuji Kohno, Mitsuru Mizuno, Kenta Katagiri, Koji Otabe, Nobutake Ozeki, Hisako Katano, Keiichiro Komori, Masafumi Horie, Kunikazu Tsuji, Mikio Matsumoto, Haruka Kaneko, Yuji Takazawa, Takeshi Muneta, Ichiro Sekiya
Organizer
Orthopaedic Research Society (ORS) 2017 Annual Meeting
Place of Presentation
San Diego Convention Center
Year and Date
2017-03-21
Related Report
Int'l Joint Research
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[Presentation] 浮遊滑膜産生細胞培養モデルによる解析2015
Author(s)
片桐 健太, 宗田 大, 松倉 遊, 辻 邦和, 大川 淳, 関矢 一郎
Organizer
第30回日本整形外科学会基礎学術集会
Place of Presentation
富山国際会議場(富山県、富山市)
Year and Date
2015-10-22
Related Report