Molecular analysis of mechanical stress response in joint formation

• Project/Area Number: 15K10467
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Gifu University
• Principal Investigator: Takigami Iori 岐阜大学, 医学部附属病院, 講師 (90610410)
• Co-Investigator(Kenkyū-buntansha): 秋山 治彦 岐阜大学, 大学院医学系研究科, 教授 (60402830)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 骨・軟骨代謝学 / 関節軟骨 / メカニカルストレス

Outline of Final Research Achievements

We investigated that the state without mechanical stress due to developmental dislocation of hip affects joint morphogenesis histologically and immunohistochemically through analysis of hip dislocation model rats. Furthermore, a mechanical stress response genes were identified in gene expression analysis. These results suggest that the genes involved in chondrogenesis and maintenance may be reduced due to the absence of appropriate mechanical stress, which may result in joint degeneration.