| Project/Area Number |
15K10469
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
Goto Koji 京都大学, 医学研究科, 特定講師 (00437229)
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| Co-Investigator(Kenkyū-buntansha) |
宗 和隆 京都大学, 医学研究科, 助教 (30514038)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 骨セメント / 生体活性 / 人工関節置換術 / 酸化チタン / 骨粗鬆症 / 生体材料 |
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| Outline of Final Research Achievements |
We conducted 29 cemented total hip arthroplasties in 18 adult female beagles using titania bone cement (TBC) or commercial polymethylmethacrylate bone cement (PBC). The dogs were killed 1, 3, 6, and 12 months postoperatively to evaluate osteoconductivity using bone-cement contact ratio (affinity index) in the acetabulum. Push-out tests were also performed with femoral specimen to evaluate bone-bonding strength at 1, 3, 6, and 12 months. The affinity indices and the bone-bonding strength of TBC were higher than those of PBC at each time interval. Histologically, TBC was in direct contact with bone without intervening with fibrous tissue over larger areas, and newly formed bone was observed along the cement. The apparent bioactivity of TBC indicates its potential utility in clinical practice.
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